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PDB: 88675 results

6NBB
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Horse liver alcohol dehydrogenase determined using single-particle cryo-EM at 200 keV
Descriptor: Alcohol dehydrogenase E chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ZINC ION
Authors:Herzik Jr, M.A, Wu, M, Lander, G.C.
Deposit date:2018-12-06
Release date:2019-03-13
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM.
Nat Commun, 10, 2019
5NJ6
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Crystal structure of a thermostabilised human protease-activated receptor-2 (PAR2) in ternary complex with Fab3949 and AZ7188 at 4.0 angstrom resolution
Descriptor: Fab3949 H, Fab3949 L, Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2
Authors:Cheng, R.K.Y, Fiez-Vandal, C, Schlenker, O, Edman, K, Aggeler, B, Brown, D.G, Brown, G, Cooke, R.M, Dumelin, C.E, Dore, A.S, Geschwindner, S, Grebner, C, Hermansson, N.-O, Jazayeri, A, Johansson, P, Leong, L, Prihandoko, R, Rappas, M, Soutter, H, Snijder, A, Sundstrom, L, Tehan, B, Thornton, P, Troast, D, Wiggin, G, Zhukov, A, Marshall, F.H, Dekker, N.
Deposit date:2017-03-28
Release date:2017-05-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
6WF0
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BU of 6wf0 by Molmil
Crystal Structure of Broadly Neutralizing Antibody 3I14 Bound to the Influenza A H3 Hemagglutinin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Harshbarger, W.D, Lockbaum, G.J, Deming, D.T, Attatippaholkun, N, Schiffer, C.A, Marasco, W.A.
Deposit date:2020-04-03
Release date:2020-11-25
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Unique structural solution from a V H 3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
Nat Commun, 12, 2021
6VIS
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BU of 6vis by Molmil
The Crystal Structure of Domain-Swapped Trimer Q108K:K40D:T53A:R58L:Q38F:Q4F:V62E Variant of HCRBPII
Descriptor: GLYCEROL, Retinol-binding protein 2
Authors:Ghanbarpour, A, Geiger, J.
Deposit date:2020-01-13
Release date:2020-09-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Human Cellular Retinol Binding Protein II Forms a Domain-Swapped Trimer Representing a Novel Fold and a New Template for Protein Engineering.
Chembiochem, 21, 2020
6WGX
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BU of 6wgx by Molmil
Cocrystal of BRD4(D1) with a selective inhibitor
Descriptor: 1,2-ETHANEDIOL, 4-(1-{1-[2-(dimethylamino)ethyl]piperidin-4-yl}-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-5-yl)-N-(3,5-dimethylphenyl)pyrimidin-2-amine, Bromodomain-containing protein 4
Authors:Johnson, J.A, Cui, H, Shi, K, Aihara, H, Pomerantz, W.C.K.
Deposit date:2020-04-06
Release date:2020-10-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement*.
Angew.Chem.Int.Ed.Engl., 60, 2021
6WDM
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BU of 6wdm by Molmil
Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Loveland, A.B, Demo, G, Korostelev, A.A.
Deposit date:2020-03-31
Release date:2020-07-01
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading.
Nature, 584, 2020
6VN0
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BU of 6vn0 by Molmil
BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
Authors:Cottrell, C.A, Shin, M, Ward, A.B.
Deposit date:2020-01-29
Release date:2020-06-24
Last modified:2020-09-16
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
Plos Pathog., 16, 2020
6VI6
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BU of 6vi6 by Molmil
Observing a ring-cleaving dioxygenase in action through a crystalline lens - a substrate monodentately bound structure
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-HYDROXYANTHRANILIC ACID, 3-hydroxyanthranilate 3,4-dioxygenase, ...
Authors:Wang, Y, Liu, F, Yang, Y, Liu, A.
Deposit date:2020-01-12
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens.
Proc.Natl.Acad.Sci.USA, 117, 2020
8DCD
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BU of 8dcd by Molmil
RNA ligase RtcB from Pyrococcus horikoshii in complex with Zn2+ and GTP
Descriptor: CHLORIDE ION, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Jacewicz, A, Dantuluri, S, Shuman, S.
Deposit date:2022-06-16
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structures of RNA ligase RtcB in complexes with divalent cations and GTP.
Rna, 28, 2022
8TW0
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BU of 8tw0 by Molmil
Crystal Structure of a synthetic ABC heterotrimeric Collagen-like Peptide at 1.53 A
Descriptor: Collagen Mimetic Peptide A, Collagen Mimetic Peptide B, Collagen Mimetic Peptide C, ...
Authors:Miller, M.D, Cole, C.C, Xu, W, Walker, D.R, Hulgan, S.A.H, Pogostin, B.H, Swain, J.W.R, Duella, R, Misiura, M, Wang, X, Kolomeisky, A.B, Phillips Jr, G.N, Hartgerink, J.D.
Deposit date:2023-08-18
Release date:2024-05-29
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding.
Nat.Chem., 2024
6WJP
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BU of 6wjp by Molmil
Crystal structure of Arginine Repressor P115Q mutant from the pathogenic bacterium Corynebacterium pseudotuberculosis bound to arginine
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ARGININE, ...
Authors:Nascimento, A.F.Z, Hernandez-Gonzalez, J.E, de Morais, M.A.B, Murakami, M.T, Carareto, C.M.A, Arni, R.K, Mariutti, R.B.
Deposit date:2020-04-14
Release date:2020-04-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:A single P115Q mutation modulates specificity in the Corynebacterium pseudotuberculosis arginine repressor.
Biochim Biophys Acta Gen Subj, 1864, 2020
8DC9
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BU of 8dc9 by Molmil
RNA ligase RtcB from Pyrococcus horikoshii in complex with Mn2+ and GTP
Descriptor: CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Jacewicz, A, Dantuluri, S, Shuman, S.
Deposit date:2022-06-16
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structures of RNA ligase RtcB in complexes with divalent cations and GTP.
Rna, 28, 2022
6PXO
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BU of 6pxo by Molmil
Human Casein Kinase 1 delta (anion-free crystallization conditions)
Descriptor: Casein kinase I isoform delta
Authors:Freeberg, A, Philpott, J.M, Tripathi, S.M, Partch, C.L.
Deposit date:2019-07-26
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch.
Elife, 9, 2020
6VIB
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BU of 6vib by Molmil
Observing a ring-cleaving dioxygenase in action through a crystalline lens - enol tautomers of ACMS bidentately bound structure
Descriptor: (2Z,3Z)-2-[(2Z)-3-hydroxyprop-2-en-1-ylidene]-3-iminobutanedioic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-hydroxyanthranilate 3,4-dioxygenase, ...
Authors:Wang, Y, Liu, F, Yang, Y, Liu, A.
Deposit date:2020-01-12
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens.
Proc.Natl.Acad.Sci.USA, 117, 2020
8DAO
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BU of 8dao by Molmil
Crystal structure of SARS-CoV-2 spike stem fusion peptide in complex with neutralizing antibody COV44-79
Descriptor: COV44-79 heavy chain constant domain, COV44-79 heavy chain variable domain, COV44-79 light chain constant domain, ...
Authors:Lin, T.H, Lee, C.C.D, Yuan, M, Wilson, I.A.
Deposit date:2022-06-13
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Broadly neutralizing antibodies target the coronavirus fusion peptide.
Science, 377, 2022
6NAX
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BU of 6nax by Molmil
Olfactomedin domain of mouse myocilin
Descriptor: CALCIUM ION, GLYCEROL, Myocilin, ...
Authors:Patterson-Orazem, A.C, Hill, S.E, Lieberman, R.L.
Deposit date:2018-12-06
Release date:2019-03-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.551 Å)
Cite:Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice.
Biochemistry, 58, 2019
7A7A
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BU of 7a7a by Molmil
Cryo-EM structure of W107R after heme uptake (2heme molecules) KatG from M. tuberculosis
Descriptor: Catalase-peroxidase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Blundell, T.L, Chaplin, A.K, Munir, A.
Deposit date:2020-08-27
Release date:2021-01-27
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis.
Structure, 29, 2021
6WP1
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BU of 6wp1 by Molmil
The Crystal Structure of Apo Domain-Swapped Trimer Q108K:K40L:T51K Variant of HCRBPII
Descriptor: ACETATE ION, GLYCEROL, Retinol-binding protein 2
Authors:Ghanbarpour, A, Geiger, J.
Deposit date:2020-04-26
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Human Cellular Retinol Binding Protein II Forms a Domain-Swapped Trimer Representing a Novel Fold and a New Template for Protein Engineering.
Chembiochem, 21, 2020
5K2A
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BU of 5k2a by Molmil
2.5 angstrom A2a adenosine receptor structure with sulfur SAD phasing using XFEL data
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 chimera, ...
Authors:Batyuk, A, Galli, L, Ishchenko, A, Han, G.W, Gati, C, Popov, P, Lee, M.-Y, Stauch, B, White, T.A, Barty, A, Aquila, A, Hunter, M.S, Liang, M, Boutet, S, Pu, M, Liu, Z.-J, Nelson, G, James, D, Li, C, Zhao, Y, Spence, J.C.H, Liu, W, Fromme, P, Katritch, V, Weierstall, U, Stevens, R.C, Cherezov, V, GPCR Network (GPCR)
Deposit date:2016-05-18
Release date:2016-09-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.
Sci Adv, 2, 2016
6GTH
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BU of 6gth by Molmil
Serial Femtosecond Crystallography at Megahertz pulse rates
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase
Authors:Wiedorn, M, Oberthuer, D, Werner, N, Schubert, R, White, T.A, Mancuso, A, Perbandt, M, Betzel, C, Barty, A, Chapman, H.
Deposit date:2018-06-18
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Megahertz serial crystallography.
Nat Commun, 9, 2018
5NJ1
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BU of 5nj1 by Molmil
The X-ray structure of the adduct formed in the reaction between hen egg white lysozyme and arsenoplatin-1
Descriptor: 1,2-ETHANEDIOL, Lysozyme C, NITRATE ION, ...
Authors:Ferraro, G, Merlino, A.
Deposit date:2017-03-27
Release date:2018-05-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Arsenoplatin-1 Is a Dual Pharmacophore Anticancer Agent.
J.Am.Chem.Soc., 141, 2019
8U48
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BU of 8u48 by Molmil
Crystal structure of Bacteroides thetaiotamicron BT1285 D161A-E163A inactive Endoglycosidase in complex with high-mannose N-glycan (Man9GlcNAc2) substrate
Descriptor: Endo-beta-N-acetylglucosaminidase, PHOSPHATE ION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Sastre, D.E, Sultana, N, Navarro, M.V.A.S, Sundberg, E.J.
Deposit date:2023-09-09
Release date:2024-05-29
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate.
Nat Commun, 15, 2024
8DCG
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BU of 8dcg by Molmil
Structure of guanylylated RNA ligase RtcB from Pyrococcus horikoshii
Descriptor: CHLORIDE ION, GUANOSINE-5'-MONOPHOSPHATE, SULFATE ION, ...
Authors:Jacewicz, A, Dantuluri, S, Shuman, S.
Deposit date:2022-06-16
Release date:2022-10-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structures of RNA ligase RtcB in complexes with divalent cations and GTP.
Rna, 28, 2022
6VZS
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BU of 6vzs by Molmil
Engineered TTLL6 mutant bound to gamma-elongation analog
Descriptor: (2~{S})-2-[[[(3~{R})-3-acetamido-4-oxidanyl-4-oxidanylidene-butyl]-phosphonooxy-phosphoryl]methyl]pentanedioic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ...
Authors:Mahalingan, K.K, Keenen, E.K, Strickland, M, Li, Y, Liu, Y, Ball, H.L, Tanner, M.E, Tjandra, N, Roll-Mecak, A.
Deposit date:2020-02-28
Release date:2020-08-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Nat.Struct.Mol.Biol., 27, 2020
5M0M
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BU of 5m0m by Molmil
Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors
Descriptor: (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ...
Authors:Keune, W.-J, Heidebrecht, T, Perrakis, A.
Deposit date:2016-10-05
Release date:2017-08-16
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators.
J. Med. Chem., 60, 2017

223166

数据于2024-07-31公开中

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