5K75
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![BU of 5k75 by Molmil](/molmil-images/mine/5k75) | IRAK4 in complex with Compound 1 | 分子名称: | Interleukin-1 receptor-associated kinase 4, SULFATE ION, ~{N}1-(7,8-dihydro-6~{H}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{N}4,~{N}4-dimethyl-cyclohexane-1,4-diamine | 著者 | Ferguson, A.D. | 登録日 | 2016-05-25 | 公開日 | 2017-12-06 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. J. Med. Chem., 60, 2017
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6P7M
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![BU of 6p7m by Molmil](/molmil-images/mine/6p7m) | Cryo-EM structure of LbCas12a-crRNA: AcrVA4 (1:2 complex) | 分子名称: | Cas12a, MAGNESIUM ION, anti-CRISPR VA4, ... | 著者 | Knott, G.J, Liu, J.J, Doudna, J.A. | 登録日 | 2019-06-06 | 公開日 | 2019-08-21 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Elife, 8, 2019
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7ZXV
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![BU of 7zxv by Molmil](/molmil-images/mine/7zxv) | Orange Carotenoid Protein Trp-288 BTA mutant | 分子名称: | CHLORIDE ION, Orange carotenoid-binding protein, beta,beta-caroten-4-one, ... | 著者 | Moldenhauer, M, Tseng, H.-W, Kraskov, A, Tavraz, N.N, Hildebrandt, P, Hochberg, G, Essen, L.-O, Budisa, N, Korf, L, Maksimov, E.G, Friedrich, T. | 登録日 | 2022-05-23 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Parameterization of a single H-bond in Orange Carotenoid Protein by atomic mutation reveals principles of evolutionary design of complex chemical photosystems. Front Mol Biosci, 10, 2023
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4IKN
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![BU of 4ikn by Molmil](/molmil-images/mine/4ikn) | Crystal structure of adaptor protein complex 3 (AP-3) mu3A subunit C-terminal domain, in complex with a sorting peptide from TGN38 | 分子名称: | AP-3 complex subunit mu-1, Trans-Golgi network integral membrane protein TGN38 | 著者 | Mardones, G.A, Kloer, D.P, Burgos, P.V, Bonifacino, J.S, Hurley, J.H. | 登録日 | 2012-12-26 | 公開日 | 2013-02-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | 主引用文献 | Structural basis for the recognition of tyrosine-based sorting signals by the mu 3A subunit of the AP-3 adaptor complex. J.Biol.Chem., 288, 2013
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5UQI
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![BU of 5uqi by Molmil](/molmil-images/mine/5uqi) | |
2HYR
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![BU of 2hyr by Molmil](/molmil-images/mine/2hyr) | Crystal structure of a complex of griffithsin with maltose | 分子名称: | 1,2-ETHANEDIOL, Griffithsin, MAGNESIUM ION, ... | 著者 | Ziolkowska, N.E, Wlodawer, A. | 登録日 | 2006-08-07 | 公開日 | 2007-04-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin. Proteins, 67, 2007
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2HZ8
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![BU of 2hz8 by Molmil](/molmil-images/mine/2hz8) | QM/MM structure refined from NMR-structure of a single chain diiron protein | 分子名称: | De novo designed diiron protein, ZINC ION | 著者 | Calhoun, J.R, Liu, W, Spiegel, K, Dal Peraro, M, Klein, M.L, Wand, A.J, DeGrado, W.F. | 登録日 | 2006-08-08 | 公開日 | 2007-07-17 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement. Structure, 16, 2008
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1SYI
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![BU of 1syi by Molmil](/molmil-images/mine/1syi) | X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION. | 分子名称: | (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID, Glutamate receptor 2 | 著者 | Frandsen, A, Pickering, D.S, Vestergaard, B, Kasper, C, Nielsen, B.B, Greenwood, J.R, Campiani, G, Gajhede, M, Schousboe, A, Kastrup, J.S. | 登録日 | 2004-04-01 | 公開日 | 2005-03-22 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2. Mol.Pharmacol., 67, 2005
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2I6S
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![BU of 2i6s by Molmil](/molmil-images/mine/2i6s) | Complement component C2a | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C2a fragment, ... | 著者 | Milder, F.J, Raaijmakers, H.C.A, Vandeputte, D.A.A, Schouten, A, Huizinga, E.G, Romijn, R.A, Hemrika, W, Roos, A, Daha, M.R, Gros, P. | 登録日 | 2006-08-29 | 公開日 | 2006-10-17 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of complement component c2a: implications for convertase formation and substrate binding. Structure, 14, 2006
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4INJ
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![BU of 4inj by Molmil](/molmil-images/mine/4inj) | Crystal structure of the S111A mutant of member of MccF clade from Listeria monocytogenes EGD-e with product | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Lmo1638 protein, ... | 著者 | Nocek, B, Tikhonov, A, Severinov, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-01-04 | 公開日 | 2013-02-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of the S111A mutant of member of MccF clade from Listeria monocytogenes EGD-e with product To be Published
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6W3V
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![BU of 6w3v by Molmil](/molmil-images/mine/6w3v) | Crystal structure of ligand-binding domain of Campylobacter jejuni chemoreceptor Tlp3 in complex with L-phenylalanine | 分子名称: | CHLORIDE ION, Methyl-accepting chemotaxis protein, PHENYLALANINE, ... | 著者 | Khan, M.F, Machuca, M.A, Rahman, M.M, Roujeinikova, A. | 登録日 | 2020-03-09 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Structure-Activity Relationship Study Reveals the Molecular Basis for Specific Sensing of Hydrophobic Amino Acids by theCampylobacter jejuniChemoreceptor Tlp3. Biomolecules, 10, 2020
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3ZKC
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![BU of 3zkc by Molmil](/molmil-images/mine/3zkc) | Crystal structure of the master regulator for biofilm formation SinR in complex with DNA. | 分子名称: | 5'-D(*AP*AP*AP*GP*TP*TP*CP*TP*CP*TP*TP*TP*AP*GP *AP*GP*AP*AP*CP*AP*AP)-3', 5'-D(*AP*TP*TP*GP*TP*TP*CP*TP*CP*TP*AP*AP*AP*GP *AP*GP*AP*AP*CP*TP*TP)-3', HTH-TYPE TRANSCRIPTIONAL REGULATOR SINR | 著者 | Newman, J.A, Rodrigues, C, Lewis, R.J. | 登録日 | 2013-01-22 | 公開日 | 2013-03-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular Basis of the Activity of Sinr, the Master Regulator of Biofilm Formation in Bacillus Subtilis. J.Biol.Chem., 288, 2013
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1T8N
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![BU of 1t8n by Molmil](/molmil-images/mine/1t8n) | CRYSTAL STRUCTURE OF THE P1 THR BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | 分子名称: | Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION | 著者 | Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. | 登録日 | 2004-05-13 | 公開日 | 2005-03-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
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6W79
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4IL2
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![BU of 4il2 by Molmil](/molmil-images/mine/4il2) | Crystal structure of D-mannonate dehydratase (rspA) from E. coli CFT073 (EFI TARGET EFI-501585) | 分子名称: | MAGNESIUM ION, Starvation sensing protein rspA | 著者 | Lukk, T, Wichelecki, D, Imker, H.J, Gerlt, J.A, Nair, S.K. | 登録日 | 2012-12-28 | 公開日 | 2013-02-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Mannonate degradation pathway in E. coli CFT073 To be Published
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2IBW
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7T1V
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1JHC
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![BU of 1jhc by Molmil](/molmil-images/mine/1jhc) | LEXA S119A C-TERMINAL TRYPTIC FRAGMENT | 分子名称: | LEXA REPRESSOR | 著者 | Luo, Y, Pfuetzner, R.A, Mosimann, S, Little, J.W, Strynadka, N.C.J. | 登録日 | 2001-06-27 | 公開日 | 2001-09-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell(Cambridge,Mass.), 106, 2001
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6PBV
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![BU of 6pbv by Molmil](/molmil-images/mine/6pbv) | Crystal structure of Fab668 complex | 分子名称: | 1,2-ETHANEDIOL, Fab668 heavy chain, Fab668 light chain, ... | 著者 | Oyen, D, Wilson, I.A. | 登録日 | 2019-06-14 | 公開日 | 2020-03-04 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.566 Å) | 主引用文献 | Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein. Plos Pathog., 16, 2020
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4IBX
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![BU of 4ibx by Molmil](/molmil-images/mine/4ibx) | Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase TEM, CALCIUM ION, ... | 著者 | Dellus-Gur, E, Toth-Petroczy, A, Elias, M, Tawfik, D.S. | 登録日 | 2012-12-09 | 公開日 | 2013-04-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs. J.Mol.Biol., 425, 2013
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5JX9
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![BU of 5jx9 by Molmil](/molmil-images/mine/5jx9) | Crystal structure of laccase from Thermus thermophilus HB27 (Cu(II)-cyclophanes, 5 min) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, COPPER (II) ION, Laccase | 著者 | Diaz-Vilchis, A, Ruiz-Arellano, R.R, Rosas-Benitez, E, Rudino-Pinera, E. | 登録日 | 2016-05-12 | 公開日 | 2017-06-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Preserving metallic sites affected by radiation damage: the CuT2 case in Thermus thermophilus multicopper oxidase To be Published
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5JXZ
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![BU of 5jxz by Molmil](/molmil-images/mine/5jxz) | A low magnesium structure of the isochorismate synthase, EntC | 分子名称: | (3R,4R)-3-[(1-carboxyethenyl)oxy]-4-hydroxycyclohexa-1,5-diene-1-carboxylic acid, (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, Isochorismate synthase EntC, ... | 著者 | Meneely, K.M, Sundlov, J.A, Gulick, A.M, Lamb, A.L. | 登録日 | 2016-05-13 | 公開日 | 2016-07-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | An Open and Shut Case: The Interaction of Magnesium with MST Enzymes. J.Am.Chem.Soc., 138, 2016
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1JLV
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![BU of 1jlv by Molmil](/molmil-images/mine/1jlv) | Anopheles dirus species B glutathione S-transferases 1-3 | 分子名称: | GLUTATHIONE, glutathione transferase GST1-3 | 著者 | Oakley, A.J, Harnnoi, T, Udomsinprasert, R, Jirajaroenrat, K, Ketterman, A.J, Wilce, M.C. | 登録日 | 2001-07-16 | 公開日 | 2002-07-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The crystal structures of glutathione S-transferases isozymes 1-3 and 1-4 from Anopheles dirus species B. Protein Sci., 10, 2001
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1JHE
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![BU of 1jhe by Molmil](/molmil-images/mine/1jhe) | LEXA L89P Q92W E152A K156A MUTANT | 分子名称: | LEXA REPRESSOR | 著者 | Luo, Y, Pfuetzner, R.A, Mosimann, S, Little, J.W, J Strynadka, N.C. | 登録日 | 2001-06-27 | 公開日 | 2001-09-19 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Cell(Cambridge,Mass.), 106, 2001
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4IE7
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![BU of 4ie7 by Molmil](/molmil-images/mine/4ie7) | Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with citrate and rhein (RHN) | 分子名称: | 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, CITRATE ANION, ... | 著者 | Aik, W.S, McDonough, M.A, Schofield, C.J. | 登録日 | 2012-12-13 | 公開日 | 2013-04-03 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6004 Å) | 主引用文献 | Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56, 2013
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