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PDB: 88675 件

6YOT
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Crystal structure of the cAMP-dependent protein kinase A cocrystallized with N,N-dimethylisoquinoline-5-sulfonamide and PKI (5-24)
分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N},~{N}-dimethylisoquinoline-5-sulfonamide
著者Oebbeke, M, Heine, A, Klebe, G.
登録日2020-04-15
公開日2021-04-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Fragment based drug design - Small chemical changes of fragments effecting big changes in binding
To Be Published
7M5B
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Crystal Structure of human BAK in complex with M3W5_BID
分子名称: BH3-interacting domain death agonist p15, Bcl-2 homologous antagonist/killer, COPPER (II) ION
著者Singh, G, Aggarwal, A, Moldoveanu, T.
登録日2021-03-23
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis of BAK activation in mitochondrial apoptosis initiation.
Nat Commun, 13, 2022
8D8S
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BU of 8d8s by Molmil
SufS from Staphylococcus aureus
分子名称: 1,2-ETHANEDIOL, Cysteine desulfurase
著者Morrison, C.N, Boncella, A.E, Lunin, V.
登録日2022-06-08
公開日2022-12-07
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.388 Å)
主引用文献Structural and Biochemical Characterization of Staphylococcus aureus Cysteine Desulfurase Complex SufSU.
Acs Omega, 7, 2022
7MFZ
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The Crystal Structure of Domain-Swapped Trimer Q108K:K40D:T53A:R58L:Q38F:Q4F Mutant of HCRBPII Bound with LizFluor3 Chromophore Showing Excited State Intermolecular Proton Transfer
分子名称: 1-(4-{5-[(2E)-but-2-en-2-yl]thiophen-2-yl}phenyl)azetidine, ACETATE ION, GLYCEROL, ...
著者Ghanbarpour, A, Geiger, J.
登録日2021-04-12
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Design of Large Stokes Shift Fluorescent Proteins Based on Excited State Proton Transfer of an Engineered Photobase.
J.Am.Chem.Soc., 143, 2021
8I0Q
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Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 (Local refine)
分子名称: Beta-arrestin-1, C-X-C chemokine receptor type 4, Fab30 Heavy Chain, ...
著者Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K.
登録日2023-01-11
公開日2023-05-17
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.45 Å)
主引用文献Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation.
Mol.Cell, 83, 2023
8I10
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Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin V2 receptor, V2R (Local refine)
分子名称: Beta-arrestin-2, Fab30 Heavy Chain, Fab30 Light Chain, ...
著者Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K.
登録日2023-01-12
公開日2023-05-17
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation.
Mol.Cell, 83, 2023
7QSZ
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Non-obligately L8S8-complex forming RubisCO derived from ancestral sequence reconstruction and rational engineering in L8 complex with substitution e170N
分子名称: 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit
著者Zarzycki, J, Schulz, L, Erb, T.J, Hochberg, G.K.A.
登録日2022-01-14
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Evolution of increased complexity and specificity at the dawn of form I Rubiscos.
Science, 378, 2022
7BAF
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Crystal structure of PAFB in complex with zinc
分子名称: ACETATE ION, Antifungal protein, ZINC ION
著者Guagnini, F, Huber, A, Alex, J.M, Marx, F, Crowley, P.B.
登録日2020-12-15
公開日2021-03-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.123 Å)
主引用文献Porous assembly of an antifungal protein mediated by zinc and sulfonato-calix[8]arene.
J.Struct.Biol., 213, 2021
8A5B
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Crystal structure of human cathepsin L in complex with covalently bound MG-101
分子名称: Calpain Inhibitor I, Cathepsin L, DI(HYDROXYETHYL)ETHER, ...
著者Falke, S, Lieske, J, Guenther, S, Reinke, P.Y.A, Ewert, W, Loboda, J, Karnicar, K, Usenik, A, Lindic, N, Sekirnik, A, Chapman, H.N, Hinrichs, W, Turk, D, Meents, A.
登録日2022-06-14
公開日2023-07-05
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.
J.Med.Chem., 67, 2024
7MFX
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The Crystal Structure of Q108K:K40H:T53A:R58L:Q38F:Q4F Mutant of HCRBPII Bound with FR1 Chromophore Showing Excited State Intermolecular Proton Transfer
分子名称: (4aP)-N,N-diethyl-9,9-dimethyl-7-[(1E)-prop-1-en-1-yl]-9H-fluoren-2-amine, GLYCEROL, Retinol-binding protein 2
著者Ghanbarpour, A, Geiger, J.
登録日2021-04-11
公開日2022-01-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Design of Large Stokes Shift Fluorescent Proteins Based on Excited State Proton Transfer of an Engineered Photobase.
J.Am.Chem.Soc., 143, 2021
7SVX
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Structure of EmrE-D3 mutant in complex with monobody L10 and harmane
分子名称: 1-methyl-9H-pyrido[3,4-b]indole, L10 monobody, Multidrug transporter EmrE
著者Kermani, A.A, Stockbridge, R.B.
登録日2021-11-19
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.9 Å)
主引用文献Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates.
Elife, 11, 2022
6NFX
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MBTD1 MBT repeats
分子名称: GLYCEROL, MBT domain-containing protein 1,Enhancer of polycomb homolog 1, SODIUM ION, ...
著者Zhang, H, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2018-12-21
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.
Cell Rep, 30, 2020
7SV9
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Structure of EmrE-D3 mutant in complex with monobody L10 and TPP
分子名称: L10 monobody, Multidrug transporter EmrE, TETRAPHENYLPHOSPHONIUM
著者Kermani, A.A, Stockbridge, R.B.
登録日2021-11-18
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.36 Å)
主引用文献Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates.
Elife, 11, 2022
7T00
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Structure of EmrE-D3 mutant in complex with monobody L10 and benzyltrimethylammonium
分子名称: L10 monobody, Multidrug transporter EmrE, benzyltrimethylammonium
著者Kermani, A.A, Stockbridge, R.B.
登録日2021-11-29
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.91 Å)
主引用文献Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates.
Elife, 11, 2022
5J6Q
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Cwp8 from Clostridium difficile
分子名称: CHLORIDE ION, Cell wall binding protein cwp8, SULFATE ION
著者Renko, M, Usenik, A, Turk, D.
登録日2016-04-05
公開日2017-02-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6.
Structure, 25, 2017
6PTL
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Structure of the self-association domain of the chromatin looping factor LDB1
分子名称: LIM domain-binding protein 1
著者Macindoe, I, Silva, A, Guss, J.M, Mackay, J.P, Matthews, J.M.
登録日2019-07-16
公開日2020-07-22
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the self-association domain of the chromatin looping factor LDB1
To Be Published
6FI0
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Crystal structure of BAZ2A PHD zinc finger in complex with Fr 19
分子名称: 2-azanyl-1-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-yl)ethanone, Bromodomain adjacent to zinc finger domain protein 2A, GLYCEROL, ...
著者Amato, A, Lucas, X, Bortoluzzi, A, Wright, D, Ciulli, A.
登録日2018-01-16
公開日2018-03-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
ACS Chem. Biol., 13, 2018
6Y1I
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Human Eg5 motor domain mutant R234C
分子名称: ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION
著者Garcia-Saez, I, Skoufias, D.A.
登録日2020-02-12
公開日2021-06-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Human Eg5 motor domain mutant R234C
To Be Published
6Y0L
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Crystal structure of human CD23 lectin domain N225D, K229E, S252N, T251N, R253G, S254G mutant
分子名称: GLYCEROL, Low affinity immunoglobulin epsilon Fc receptor membrane-bound form, SULFATE ION
著者Ilkow, V.F, Davies, A.M, Sutton, B.J, McDonnell, J.M.
登録日2020-02-09
公開日2021-06-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
Febs Open Bio, 11, 2021
4WRW
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BU of 4wrw by Molmil
Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase, Form IV
分子名称: CHLORIDE ION, GLYCEROL, Uracil-DNA glycosylase
著者Arif, S.M, Geethanandan, K, Mishra, P, Surolia, A, Varshney, U, Vijayan, M.
登録日2014-10-25
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.
Acta Crystallogr.,Sect.D, 71, 2015
6FJ8
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Structure of Thaumatin collected from an in situ crystal collected on ID30B at 12.7 keV.
分子名称: L(+)-TARTARIC ACID, Thaumatin-1
著者McCarthy, A.A, Mueller-Dieckmann, C.
登録日2018-01-21
公開日2018-01-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献ID30B - a versatile beamline for macromolecular crystallography experiments at the ESRF.
J Synchrotron Radiat, 25, 2018
4WS1
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BU of 4ws1 by Molmil
Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 5-fluorouracil (AB), Form II
分子名称: 1,2-ETHANEDIOL, 5-FLUOROURACIL, CHLORIDE ION, ...
著者Arif, S.M, Geethanandan, K, Mishra, P, Surolia, A, Varshney, U, Vijayan, M.
登録日2014-10-25
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.
Acta Crystallogr.,Sect.D, 71, 2015
7SSU
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BU of 7ssu by Molmil
Structure of EmrE-D3 mutant in complex with monobody L10 and methyltriphenylphosphonium
分子名称: L10 monobody, Multidrug transporter EmrE, methyltriphenylphosphonium
著者Kermani, A.A, Stockbridge, R.B.
登録日2021-11-11
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates.
Elife, 11, 2022
4WQC
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Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum - K208N mutant
分子名称: 1,2-ETHANEDIOL, HEME C, SULFATE ION, ...
著者Brito, J.A, Denkmann, K, Pereira, I.A.C, Dahl, C, Archer, M.
登録日2014-10-21
公開日2015-02-18
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Thiosulfate Dehydrogenase (TsdA) from Allochromatium vinosum: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO THIOSULFATE OXIDATION.
J.Biol.Chem., 290, 2015
7MP3
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Grb7-SH2 domain in complex with bicyclic peptide B8
分子名称: Growth factor receptor-bound protein 7, bicyclic peptide B8
著者Colson, R, Wilce, M.C.J, Wilce, J.A.
登録日2021-05-04
公開日2022-02-02
最終更新日2024-04-17
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability.
Biomedicines, 10, 2022

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件を2024-07-31に公開中

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