8Q68
 
 | | Crystal structure of TEAD1-YBD in complex with irreversible compound SWTX-143 | | 分子名称: | Transcriptional enhancer factor TEF-1, ~{N}-[(3~{S})-5-azanyl-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2~{H}-quinolin-3-yl]propanamide | | 著者 | Ciesielski, F, Spieser, S.A.H, Marchand, A, Gwaltney, S.L. | | 登録日 | 2023-08-11 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.
Mol.Cancer Ther., 23, 2024
|
|
7NES
 | |
4MT5
 | |
7NNH
 | |
3ZQS
 | | Human FANCL central domain | | 分子名称: | E3 UBIQUITIN-PROTEIN LIGASE FANCL, HEXAETHYLENE GLYCOL, PROLINE, ... | | 著者 | Hodson, C, Cole, A.R, Purkiss-Trew, A, Walden, H. | | 登録日 | 2011-06-10 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Analysis of Human Fancl, the E3 Ligase in the Fanconi Anemia Pathway.
J.Biol.Chem., 286, 2011
|
|
5AQH
 | | Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues | | 分子名称: | 5-methyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, DIMETHYL SULFOXIDE, ... | | 著者 | Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. | | 登録日 | 2015-09-22 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Sci Rep, 6, 2016
|
|
6EK6
 | | Crystal structure of KDM5B in complex with S49195a. | | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Lysine-specific demethylase 5B,Lysine-specific demethylase 5B, ... | | 著者 | Srikannathasan, V, Szykowska, A, Newman, J.A, Ruda, G.F, Strain-Damerell, C, Burgess-Brown, N.A, Vazquez-Rodriguez, S, Wright, M, Brennan, P.E, Arrowsmith, C.H, Edwards, A, Bountra, C, Oppermann, U, Huber, K, von Delft, F. | | 登録日 | 2017-09-25 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structure of KDM5B in complex with S49195a.
To be published
|
|
2OX5
 | | The SoxYZ complex of Paracoccus pantotrophus | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | | 著者 | Bruno, S, Sauve, V, Berks, B.C, Hemmings, A.M. | | 登録日 | 2007-02-19 | | 公開日 | 2007-05-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | The SoxYZ Complex Carries Sulfur Cycle Intermediates on a Peptide Swinging Arm.
J.Biol.Chem., 282, 2007
|
|
7RXD
 | | CryoEM structure of RBD domain of COVID-19 in complex with Legobody | | 分子名称: | Fab_8D3_2 heavy chain, Fab_8D3_2 light chain, Maltodextrin-binding protein,Immunoglobulin G-binding protein A,Immunoglobulin G-binding protein G, ... | | 著者 | Wu, X.D, Rapoport, T.A. | | 登録日 | 2021-08-22 | | 公開日 | 2021-10-06 | | 最終更新日 | 2021-10-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies).
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7RXC
 | | CryoEM structure of KDELR with Legobody | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ER lumen protein-retaining receptor 2, Fab_8D3_2 heavy chain, ... | | 著者 | Wu, X.D, Rapoport, T.A. | | 登録日 | 2021-08-22 | | 公開日 | 2021-10-06 | | 最終更新日 | 2021-10-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies).
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
6E5T
 | | Crystal structure of human cellular retinol binding protein 1 in complex with abnormal-cannabidiorcin (Abn-CBDO) | | 分子名称: | (1'R,2'R)-5',6-dimethyl-2'-(prop-1-en-2-yl)-1',2',3',4'-tetrahydro[1,1'-biphenyl]-2,4-diol, Retinol-binding protein 1 | | 著者 | Silvaroli, J.A, Horwitz, S, Banerjee, S, Kiser, P.D, Golczak, M. | | 登録日 | 2018-07-23 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1.
Acs Chem.Biol., 14, 2019
|
|
7S0L
 | |
8CL4
 | |
3ZHC
 | | Structure of the phytase from Citrobacter braakii at 2.3 angstrom resolution. | | 分子名称: | CHLORIDE ION, FORMIC ACID, PHYTASE | | 著者 | Wilson, K.S, Ariza, A, Sanchez-Romero, I, Skjot, M, Vind, J, DeMaria, L, Skov, L.K, Sanchez-Ruiz, J.M. | | 登録日 | 2012-12-20 | | 公開日 | 2013-08-28 | | 最終更新日 | 2017-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Mechanism of Protein Kinetic Stabilization by Engineered Disulfide Crosslinks
Plos One, 8, 2013
|
|
6OR3
 | |
1UEH
 | | E. coli undecaprenyl pyrophosphate synthase in complex with Triton X-100, magnesium and sulfate | | 分子名称: | MAGNESIUM ION, OXTOXYNOL-10, SULFATE ION, ... | | 著者 | Chang, S.-Y, Ko, T.-P, Liang, P.-H, Wang, A.H.-J. | | 登録日 | 2003-05-15 | | 公開日 | 2003-08-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Catalytic mechanism revealed by the crystal structure of undecaprenyl pyrophosphate synthase in complex with sulfate, magnesium, and triton
J.Biol.Chem., 278, 2003
|
|
3ZTX
 | | Aurora kinase selective inhibitors identified using a Taxol-induced checkpoint sensitivity screen. | | 分子名称: | 2-((4-(4-HYDROXYPIPERIDIN-1-YL)PHENYL)AMINO)-5,11-DIMETHYL-5H-BENZO[E]PYRIMIDO [5,4-B][1,4]DIAZEPIN-6(11H)-ONE, INNER CENTROMERE PROTEIN A, SERINE/THREONINE-PROTEIN KINASE 12-A | | 著者 | Kwiatkowski, N, Villa, F, Musacchio, A, Gray, N. | | 登録日 | 2011-07-12 | | 公開日 | 2012-02-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Selective Aurora Kinase Inhibitors Identified Using a Taxol- Induced Checkpoint Sensitivity Screen.
Acs Chem.Biol., 7, 2012
|
|
8CL0
 | |
3X1B
 | | Crystal structure of laccase from Lentinus sp. at 1.8 A resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COPPER (II) ION, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jeng, W.Y, Shyur, L.F, Wang, A.H.J. | | 登録日 | 2014-10-31 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of laccase from Lentinus sp. at 1.8 A resolution
To be Published
|
|
6E7M
 | |
6OGK
 | | MeCP2 MBD in complex with DNA | | 分子名称: | CALCIUM ION, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), ... | | 著者 | Lei, M, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | | 登録日 | 2019-04-02 | | 公開日 | 2019-05-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
|
|
8CL2
 | |
3ZO7
 | | Crystal structure of ClcFE27A with substrate | | 分子名称: | (2S)-2-chloranyl-2-[(2R)-5-oxidanylidene-2H-furan-2-yl]ethanoic acid, 5-CHLOROMUCONOLACTONE DEHALOGENASE, CHLORIDE ION | | 著者 | Roth, C, Groening, J.A.D, Kaschabek, S.R, Schloemann, M, Straeter, N. | | 登録日 | 2013-02-20 | | 公開日 | 2013-03-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.224 Å) | | 主引用文献 | Crystal Structure and Catalytic Mechanism of Chloromuconolactone Dehalogenase Clcf from Rhodococcus Opacus 1Cp.
Mol.Microbiol., 88, 2013
|
|
6OUM
 | |
7N67
 | | Crystal structure of HCAN_0198, a 3,4-ketoisomerase from Helicobacter canadensis | | 分子名称: | FdtA domain-containing protein, TETRAMETHYLAMMONIUM ION, THYMIDINE-5'-DIPHOSPHATE | | 著者 | Heisdorf, C.J, Griffiths, W.A, Thoden, J.B, Holden, H.M. | | 登録日 | 2021-06-07 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis.
Protein Sci., 30, 2021
|
|
