6Z9K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6z9k by Molmil](/molmil-images/mine/6z9k) | CAP domain of Enterococcal PrgA | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MAGNESIUM ION, PrgA | 著者 | Berntsson, R.P.A, Schmitt, A. | 登録日 | 2020-06-04 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Enterococcal PrgA Extends Far Outside the Cell and Provides Surface Exclusion to Protect against Unwanted Conjugation. J.Mol.Biol., 432, 2020
|
|
7MDP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mdp by Molmil](/molmil-images/mine/7mdp) | KRas G12C in complex with G-2897 | 分子名称: | 1,2-ETHANEDIOL, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 4-(trifluoromethyl)-1,3-benzothiazol-2-amine, ... | 著者 | Oh, A, Frank, Y, Wang, W. | 登録日 | 2021-04-05 | 公開日 | 2022-03-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors. Nat.Biotechnol., 40, 2022
|
|
6WMK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wmk by Molmil](/molmil-images/mine/6wmk) | Crystal structure of beta sheet heterodimer LHD29 | 分子名称: | Beta sheet heterodimer LHD29 - Chain A, Beta sheet heterodimer LHD29 - Chain B | 著者 | Bera, A.K, Sahtoe, D.D, Kang, A, Sankaran, B, Baker, D. | 登録日 | 2020-04-21 | 公開日 | 2021-11-10 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Reconfigurable asymmetric protein assemblies through implicit negative design. Science, 375, 2022
|
|
6W1Z
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w1z by Molmil](/molmil-images/mine/6w1z) | ClpAP Engaged1 State bound to RepA-GFP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpA, ... | 著者 | Lopez, K.L, Rizo, A.N, Tse, E, Lin, J, Scull, N.W, Thwin, A.C, Lucius, A.L, Shorter, J, Southworth, D.R. | 登録日 | 2020-03-04 | 公開日 | 2020-05-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nat.Struct.Mol.Biol., 27, 2020
|
|
6WXQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wxq by Molmil](/molmil-images/mine/6wxq) | |
6Q76
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6q76 by Molmil](/molmil-images/mine/6q76) | |
8VAN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8van by Molmil](/molmil-images/mine/8van) | Structure of the E. coli clamp loader bound to the beta clamp in an Initial-Binding conformation | 分子名称: | Beta sliding clamp, DNA polymerase III subunit delta, DNA polymerase III subunit delta', ... | 著者 | Landeck, J.T, Pajak, J, Kelch, B.A. | 登録日 | 2023-12-11 | 公開日 | 2024-03-27 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | Differences between bacteria and eukaryotes in clamp loader mechanism, a conserved process underlying DNA replication. J.Biol.Chem., 300, 2024
|
|
8VAT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vat by Molmil](/molmil-images/mine/8vat) | |
6X1K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x1k by Molmil](/molmil-images/mine/6x1k) | Solution NMR structure of de novo designed TMB2.3 | 分子名称: | De novo designed transmembrane beta-barrel TMB2.3 | 著者 | Liang, B, Vorobieva, A.A, Chow, C.M, Baker, D, Tamm, L.K. | 登録日 | 2020-05-19 | 公開日 | 2021-02-17 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of transmembrane beta barrels. Science, 371, 2021
|
|
5IT8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5it8 by Molmil](/molmil-images/mine/5it8) | High-resolution structure of the Escherichia coli ribosome | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | 著者 | Cocozaki, A, Ferguson, A. | 登録日 | 2016-03-16 | 公開日 | 2016-07-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
6Q8W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6q8w by Molmil](/molmil-images/mine/6q8w) | Respiratory complex I from Thermus thermophilus with bound Aureothin. | 分子名称: | Aureothin, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... | 著者 | Gutierrez-Fernandez, J, Minhas, G.S, Sazanov, L.A. | 登録日 | 2018-12-16 | 公開日 | 2020-09-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Key role of quinone in the mechanism of respiratory complex I. Nat Commun, 11, 2020
|
|
6QAH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qah by Molmil](/molmil-images/mine/6qah) | ERK2 mini-fragment binding | 分子名称: | 1-azanylpropylideneazanium, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | O'Reilly, M, Cleasby, A, Davies, T.G, Hall, R, Ludlow, F, Murray, C.W, Tisi, D, Jhoti, H. | 登録日 | 2018-12-19 | 公開日 | 2019-06-26 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design. Drug Discov Today, 24, 2019
|
|
6QB5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qb5 by Molmil](/molmil-images/mine/6qb5) | Crystal structure of the N-terminal region of human cohesin subunit STAG1 | 分子名称: | Cohesin subunit SA-1, SODIUM ION | 著者 | Newman, J.A, Katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. | 登録日 | 2018-12-20 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. Life Sci Alliance, 3, 2020
|
|
8D3G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8d3g by Molmil](/molmil-images/mine/8d3g) | |
5N35
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n35 by Molmil](/molmil-images/mine/5n35) | Gadolinium phased PBP2 (SSO6202) at 2.2 Ang | 分子名称: | GADOLINIUM ATOM, GLYCEROL, NITRATE ION, ... | 著者 | Yan, J, Beattie, T.R, Rojas, A.L, Schermerhorn, K, Gristwood, T, Trinidad, J.C, Albers, S.V, Roversi, P, Gardner, A.F, Abrescia, N.G.A, Bell, S.D. | 登録日 | 2017-02-08 | 公開日 | 2017-05-17 | 最終更新日 | 2017-12-06 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme. Nat Commun, 8, 2017
|
|
8UTA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8uta by Molmil](/molmil-images/mine/8uta) | yjdF riboswitch from R. gauvreauii in complex with proflavine bound to Fab BL3-6 S97N | 分子名称: | Fab BL3-6 S97N heavy chain, Fab BL3-6 S97N light chain, MAGNESIUM ION, ... | 著者 | Krochmal, D, Lewicka, A, Piccirilli, J.A. | 登録日 | 2023-10-30 | 公開日 | 2024-04-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov, 10, 2024
|
|
6QC6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qc6 by Molmil](/molmil-images/mine/6qc6) | Ovine respiratory complex I FRC open class 1 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ... | 著者 | Letts, J.A, Sazanov, L.A. | 登録日 | 2018-12-27 | 公開日 | 2019-08-21 | 最終更新日 | 2019-10-02 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk. Mol.Cell, 75, 2019
|
|
5N7C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n7c by Molmil](/molmil-images/mine/5n7c) | Human TTR altered conformation from soaking in CuCl2. | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, COPPER (II) ION, ... | 著者 | Ciccone, L, Savko, M, Shepard, W, Stura, E.A. | 登録日 | 2017-02-20 | 公開日 | 2018-03-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Copper mediated amyloid-beta binding to Transthyretin. Sci Rep, 8, 2018
|
|
7U2S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7u2s by Molmil](/molmil-images/mine/7u2s) | Structure of Paenibacillus xerothermodurans Apyc1 in the apo state | 分子名称: | Apyc1, ZINC ION | 著者 | Hobbs, S.J, Wein, T, Lu, A, Morehouse, B.R, Schnabel, J, Sorek, R, Kranzusch, P.J. | 登録日 | 2022-02-24 | 公開日 | 2022-04-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature, 605, 2022
|
|
6X9Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6x9y by Molmil](/molmil-images/mine/6x9y) | The crystal structure of a Beta-lactamase from Escherichia coli CFT073 | 分子名称: | Beta-lactamase, GLYCEROL, S,R MESO-TARTARIC ACID, ... | 著者 | Tan, K, Wu, R, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-06-03 | 公開日 | 2020-06-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The crystal structure of a Beta-lactamase from Escherichia coli CFT073 To Be Published
|
|
6NTG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ntg by Molmil](/molmil-images/mine/6ntg) | Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234 in Complex with Reactivator, HI-6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(AMINOCARBONYL)-1-[({2-[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]PYRIDINIUM, ... | 著者 | Bester, S.M, Guelta, M.A, Height, J.J, Pegan, S.D. | 登録日 | 2019-01-29 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.652 Å) | 主引用文献 | Insights into inhibition of human acetylcholinesterase by Novichok, A-series Nerve Agents To Be Published
|
|
8VAM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vam by Molmil](/molmil-images/mine/8vam) | |
4YUP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yup by Molmil](/molmil-images/mine/4yup) | Multiconformer fixed-target X-ray free electron (XFEL) model of CypA at 273 K | 分子名称: | Peptidyl-prolyl cis-trans isomerase A | 著者 | Keedy, D.A, Kenner, L.R, Warkentin, M, Woldeyes, R.A, Thompson, M.C, Brewster, A.S, Van Benschoten, A.H, Baxter, E.L, Hopkins, J.B, Uervirojnangkoorn, M, McPhillips, S.E, Song, J, Mori, R.A, Holton, J.M, Weis, W.I, Brunger, A.T, Soltis, M, Lemke, H, Gonzalez, A, Sauter, N.K, Cohen, A.E, van den Bedem, H, Thorne, R.E, Fraser, J.S. | 登録日 | 2015-03-18 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography. Elife, 4, 2015
|
|
6QES
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6qes by Molmil](/molmil-images/mine/6qes) | [1-40]Gga-AvBD11 | 分子名称: | Gallinacin-11 | 著者 | Meudal, H, Loth, K, Delmas, A.F, Landon, C. | 登録日 | 2019-01-08 | 公開日 | 2019-12-18 | 最終更新日 | 2020-01-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure, function, and evolution ofGga-AvBD11, the archetype of the structural avian-double-beta-defensin family. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6VOU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vou by Molmil](/molmil-images/mine/6vou) | Aminoglycoside N-2'-Acetyltransferase-Ia [AAC(2')-Ia] in complex with acetylated-plazomicin and CoA | 分子名称: | (2S)-N-[(1R,2S,3S,4R,5S)-4-{[(2S,3R)-3-(acetylamino)-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-5-amino-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-4-amino-2-hydroxybutanamide, (4S)-2-METHYL-2,4-PENTANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, ... | 著者 | Bassenden, A.V, Berghuis, A.M. | 登録日 | 2020-01-31 | 公開日 | 2021-06-02 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural basis for plazomicin antibiotic action and resistance. Commun Biol, 4, 2021
|
|