8PVO
| Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric compound FG5 | 分子名称: | 1,2-ETHANEDIOL, 2-[1-(1,3-benzothiazol-6-ylsulfonyl)piperidin-4-yl]-~{N}-[(3-chloranyl-4-phenyl-phenyl)methyl]ethanamine, Casein kinase II subunit alpha, ... | 著者 | Kraemer, A, Greco, F, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2023-07-18 | 公開日 | 2023-09-20 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276, 2024
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6B4V
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7BUF
| Cryo-EM structure of Dengue virus serotype 2 complexed with SIgN-3C IgG | 分子名称: | Dengue virus serotype 2 E protein, Dengue virus serotype 2 M protein, SIgN-3C IgG heavy chain, ... | 著者 | Zhang, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Lok, S.M. | 登録日 | 2020-04-06 | 公開日 | 2020-05-13 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell Rep, 31, 2020
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4RPI
| Crystal Structure of Nicotinate Mononucleotide Adenylyltransferase from Mycobacterium tuberculosis | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, nicotinate-nucleotide adenylyltransferase | 著者 | Rodionova, I, Zuccola, H, Sorci, L, Aleshin, A.E, Kazanov, M, Sergienko, E, Rubin, E, Locher, C, Osterman, A. | 登録日 | 2014-10-30 | 公開日 | 2015-01-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.417 Å) | 主引用文献 | Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. J. Biol. Chem., 290, 2015
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5NPN
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5N74
| Microtubule end binding protein complex | 分子名称: | Karyogamy protein KAR9, Microtubule-associated protein RP/EB family member 1 | 著者 | Kumar, A, Steinmetz, M. | 登録日 | 2017-02-18 | 公開日 | 2017-06-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends. Structure, 25, 2017
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4RQY
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6QSY
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5N4S
| VIM-2 metallo-beta-lactamase in complex with ((S)-3-mercapto-2-methylpropanoyl)-D-tryptophan (Compound 3) | 分子名称: | (2~{R})-3-(1~{H}-indol-3-yl)-2-[[(2~{S})-2-methyl-3-sulfanyl-propanoyl]amino]propanoic acid, Beta-lactamase VIM-2, FORMIC ACID, ... | 著者 | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | 登録日 | 2017-02-11 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition. Chem. Commun. (Camb.), 53, 2017
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5NQN
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5N58
| di-Zinc VIM-5 metallo-beta-lactamase in complex with (1-chloro-4-hydroxyisoquinoline-3-carbonyl)-D-tryptophan (Compound 1) | 分子名称: | (2~{R})-2-[(1-chloranyl-4-oxidanyl-isoquinolin-3-yl)carbonylamino]-3-(1~{H}-indol-3-yl)propanoic acid, Class B metallo-beta-lactamase, GLYCEROL, ... | 著者 | Li, G.-B, Brem, J, McDonough, M.A, Schofield, C.J. | 登録日 | 2017-02-13 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.957 Å) | 主引用文献 | Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-beta-lactamase inhibition. Chem. Commun. (Camb.), 53, 2017
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6YL7
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8PEJ
| CjGH35 with a Galactosidase Activity-Based Probe | 分子名称: | (1~{S},2~{S},4~{S},5~{R})-6-(hydroxymethyl)cyclohexane-1,2,3,4,5-pentol, ACETATE ION, Beta-galactosidase, ... | 著者 | Offen, W.A, Davies, G.J. | 登録日 | 2023-06-14 | 公開日 | 2023-10-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The development of a broad-spectrum retaining beta-exo-galactosidase activity-based probe. Org.Biomol.Chem., 21, 2023
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8CJJ
| Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-06-057 | 分子名称: | 3-ethyl-7-(phenylmethyl)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 | 著者 | Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. | 登録日 | 2023-02-13 | 公開日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.66415656 Å) | 主引用文献 | Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023
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8PO9
| Polyethylene oxidation hexamerin PEase Cibeles (XP_026756460) from Galleria mellonella | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Arylphorin, ... | 著者 | Illanes-Vicioso, R, Ruiz-Lopez, E, Sola, M, Bertocchini, F, Palomo, E.A. | 登録日 | 2023-07-03 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Plastic degradation by insect hexamerins: Near-atomic resolution structures of the polyethylene-degrading proteins from the wax worm saliva. Sci Adv, 9, 2023
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7QDF
| Hexameric HIV-1 (M-group) CA R120 mutant | 分子名称: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Gag polyprotein, ... | 著者 | Govasli, M.A.L, Pinotsis, N, McAlpine-Scott, S. | 登録日 | 2021-11-26 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | 主引用文献 | Evasion of cGAS and TRIM5 defines pandemic HIV. Nat Microbiol, 7, 2022
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6YJW
| Structure of Fragaria ananassa O-methyltransferase crystallized with PAS polypeptide | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, O-methyltransferase, ... | 著者 | Schiefner, A, Skerra, A. | 登録日 | 2020-04-05 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Proline/alanine-rich sequence (PAS) polypeptides as an alternative to PEG precipitants for protein crystallization. Acta Crystallogr.,Sect.F, 76, 2020
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8IC1
| endo-alpha-D-arabinanase EndoMA1 D51N mutant from Microbacterium arabinogalactanolyticum in complex with arabinooligosaccharides | 分子名称: | (3~{a}~{S},5~{R},6~{R},6~{a}~{S})-5-(hydroxymethyl)-2,2-dimethyl-3~{a},5,6,6~{a}-tetrahydrofuro[2,3-d][1,3]dioxol-6-ol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Li, J, Nakashima, C, Ishiwata, A, Fujita, K, Fushinobu, S. | 登録日 | 2023-02-10 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Identification and characterization of endo-alpha-, exo-alpha-, and exo-beta-D-arabinofuranosidases degrading lipoarabinomannan and arabinogalactan of mycobacteria. Nat Commun, 14, 2023
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8G2C
| Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | 登録日 | 2023-02-03 | 公開日 | 2023-12-27 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2B
| Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | 登録日 | 2023-02-03 | 公開日 | 2023-12-27 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8G2A
| Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S. | 登録日 | 2023-02-03 | 公開日 | 2023-12-27 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat.Chem.Biol., 20, 2024
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8PNW
| Crystal structure of D-amino acid aminotransferase from Blastococcus saxobsidens in holo form with PLP | 分子名称: | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase, CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE | 著者 | Matyuta, I.O, Boyko, K.M, Nikolaeva, A.Y, Shilova, S.A, Popov, V.O. | 登録日 | 2023-07-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Expanded Substrate Specificity in D-Amino Acid Transaminases: A Case Study of Transaminase from Blastococcus saxobsidens. Int J Mol Sci, 24, 2023
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7QVI
| Fiber-forming RubisCO derived from ancestral sequence reconstruction and rational engineering | 分子名称: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, RubisCO large subunit | 著者 | Schulz, L, Zarzycki, J, Prinz, S, Schuller, J.M, Erb, T.J, Hochberg, G.K.A. | 登録日 | 2022-01-21 | 公開日 | 2022-10-12 | 最終更新日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science, 378, 2022
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7OG4
| Human mitochondrial ribosome in complex with P/E-tRNA | 分子名称: | 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... | 著者 | Aibara, S, Singh, V, Modelska, A, Amunts, A. | 登録日 | 2021-05-06 | 公開日 | 2021-06-23 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of mitochondrial translation. Elife, 9, 2020
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8PNY
| Crystal structure of D-amino acid aminotransferase from Blastococcus saxobsidens complexed with phenylhydrazine and in its apo form | 分子名称: | Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase, [6-methyl-5-oxidanyl-4-[(2-phenylhydrazinyl)methyl]pyridin-3-yl]methyl dihydrogen phosphate | 著者 | Matyuta, I.O, Boyko, K.M, Nikolaeva, A.Y, Shilova, S.A, Popov, V.O. | 登録日 | 2023-07-03 | 公開日 | 2023-10-25 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Expanded Substrate Specificity in D-Amino Acid Transaminases: A Case Study of Transaminase from Blastococcus saxobsidens. Int J Mol Sci, 24, 2023
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