7MNQ
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![BU of 7mnq by Molmil](/molmil-images/mine/7mnq) | Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP | 分子名称: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MNT
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![BU of 7mnt by Molmil](/molmil-images/mine/7mnt) | Crystal Structure of the ZnF5 or ZnF6 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP | 分子名称: | E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7MO3
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![BU of 7mo3 by Molmil](/molmil-images/mine/7mo3) | Crystal Structure of the ZnF3 of Nucleoporin NUP153 in complex with Ran-GDP, resolution 2.05 Angstrom | 分子名称: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. | 登録日 | 2021-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
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7OYB
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![BU of 7oyb by Molmil](/molmil-images/mine/7oyb) | Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | 登録日 | 2021-06-24 | 公開日 | 2022-07-13 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | A molecular network of conserved factors keeps ribosomes dormant in the egg. Nature, 613, 2023
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7OYA
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![BU of 7oya by Molmil](/molmil-images/mine/7oya) | Cryo-EM structure of the 1 hpf zebrafish embryo 80S ribosome | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | 登録日 | 2021-06-24 | 公開日 | 2022-07-13 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A molecular network of conserved factors keeps ribosomes dormant in the egg. Nature, 613, 2023
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7OY0
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![BU of 7oy0 by Molmil](/molmil-images/mine/7oy0) | Structure of human Spermine Oxidase in complex with a highly selective allosteric inhibitor | 分子名称: | 4-[(4-imidazo[1,2-a]pyridin-3-yl-1,3-thiazol-2-yl)amino]phenol, CHLORIDE ION, FAD-MDL72527 adduct, ... | 著者 | Impagliazzo, A, Thomsen, M, Johannsson, S, Krapp, S. | 登録日 | 2021-06-23 | 公開日 | 2022-07-13 | 最終更新日 | 2022-08-17 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor. Commun Biol, 5, 2022
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7P0K
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![BU of 7p0k by Molmil](/molmil-images/mine/7p0k) | Crystal structure of Autotaxin (ENPP2) with 18F-labeled positron emission tomography ligand | 分子名称: | 2-[[2-ethyl-6-[4-[2-[(3~{R})-3-fluoranylpyrrolidin-1-yl]-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-2,3-dihydro-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Salgado-Polo, F, Shao, T, Xiao, Z, Van, R, Chen, J, Rong, J, Haider, A, Shao, Y, Josephson, L, Perrakis, A, Liang, S.H. | 登録日 | 2021-06-29 | 公開日 | 2022-07-13 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Imaging Autotaxin In Vivo with 18 F-Labeled Positron Emission Tomography Ligands J Med Chem, 64, 2021
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8EA8
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![BU of 8ea8 by Molmil](/molmil-images/mine/8ea8) | NKG2D complexed with inhibitor 4a | 分子名称: | DI(HYDROXYETHYL)ETHER, N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ... | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2022-08-28 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120, 2023
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7OW5
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![BU of 7ow5 by Molmil](/molmil-images/mine/7ow5) | |
7OW6
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![BU of 7ow6 by Molmil](/molmil-images/mine/7ow6) | |
4ROB
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![BU of 4rob by Molmil](/molmil-images/mine/4rob) | 2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae | 分子名称: | Serpin 2 | 著者 | Lovell, S, Battaile, K.P, Zhang, X, Meekins, D.A, An, C, Michel, K. | 登録日 | 2014-10-28 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | 2.8A resolution structure of SRPN2 (K198C) from Anopheles gambiae To be Published
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8EA7
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![BU of 8ea7 by Molmil](/molmil-images/mine/8ea7) | NKG2D complexed with inhibitor 3g | 分子名称: | (4M)-N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4-(1-methyl-1H-pyrazol-5-yl)-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, DI(HYDROXYETHYL)ETHER, NKG2-D type II integral membrane protein | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2022-08-28 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-10 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120, 2023
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7OYC
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![BU of 7oyc by Molmil](/molmil-images/mine/7oyc) | Cryo-EM structure of the Xenopus egg 80S ribosome | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Leesch, F, Lorenzo-Orts, L, Grishkovskaya, I, Kandolf, S, Belacic, K, Meinhart, A, Haselbach, D, Pauli, A. | 登録日 | 2021-06-24 | 公開日 | 2022-07-20 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | A molecular network of conserved factors keeps ribosomes dormant in the egg. Nature, 613, 2023
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8EA5
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![BU of 8ea5 by Molmil](/molmil-images/mine/8ea5) | NKG2D complexed with inhibitor 1a | 分子名称: | (3S,5aS,8aR)-3-benzyl-6-[(3,5-dichlorophenyl)methyl]-1,4-dimethyloctahydropyrrolo[3,2-e][1,4]diazepine-2,5-dione, NKG2-D type II integral membrane protein, TRIETHYLENE GLYCOL | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2022-08-28 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-10 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120, 2023
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7P56
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![BU of 7p56 by Molmil](/molmil-images/mine/7p56) | Variant Surface Glycoprotein 2 (VSG2, MiTat1.2, VSG221) Bound to Calcium | 分子名称: | CALCIUM ION, Variant surface glycoprotein MITAT 1.2, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gkeka, A, Aresta-Branco, F, Stebbins, C.E, Papavasiliou, F.N. | 登録日 | 2021-07-14 | 公開日 | 2022-07-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.735 Å) | 主引用文献 | Immunodominant surface epitopes power immune evasion in the African trypanosome. Cell Rep, 42, 2023
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8EA9
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![BU of 8ea9 by Molmil](/molmil-images/mine/8ea9) | NKG2D complexed with inhibitor 4d | 分子名称: | DI(HYDROXYETHYL)ETHER, N-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-(dimethylamino)-2-oxoethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein, ... | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2022-08-28 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-10 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120, 2023
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6OID
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![BU of 6oid by Molmil](/molmil-images/mine/6oid) | Redox Regulation of FN3K from Arabidopsis thaliana | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | Wood, Z.A, Kadirvelraj, R, Shrestha, S. | 登録日 | 2019-04-09 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.365 Å) | 主引用文献 | A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily. Sci.Signal., 13, 2020
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8EA6
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![BU of 8ea6 by Molmil](/molmil-images/mine/8ea6) | NKG2D complexed with inhibitor 3e | 分子名称: | N-{(1S)-2-(dimethylamino)-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl}-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2022-08-28 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EAB
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![BU of 8eab by Molmil](/molmil-images/mine/8eab) | NKG2D complexed with inhibitor 4f | 分子名称: | DI(HYDROXYETHYL)ETHER, N-[(1S)-2-oxo-1-[3-(trifluoromethyl)phenyl]-2-({4-[4-(trifluoromethyl)phenyl]pyridin-3-yl}amino)ethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, NKG2-D type II integral membrane protein | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2022-08-28 | 公開日 | 2023-05-03 | 最終更新日 | 2023-05-10 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120, 2023
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8EAA
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![BU of 8eaa by Molmil](/molmil-images/mine/8eaa) | NKG2D complexed with inhibitor 4e | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, N-{(1S)-2-(dimethylamino)-1-[3-methyl-5-(trifluoromethyl)phenyl]-2-oxoethyl}-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide, ... | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2022-08-28 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Identification of small-molecule protein-protein interaction inhibitors for NKG2D. Proc.Natl.Acad.Sci.USA, 120, 2023
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6OPP
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![BU of 6opp by Molmil](/molmil-images/mine/6opp) | Asymmetric model of CD4- and 17-bound B41 HIV-1 Env SOSIP in complex with DDM | 分子名称: | 17b Fab heavy chain, 17b Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2019-04-25 | 公開日 | 2020-10-21 | 最終更新日 | 2020-12-09 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide. Cell Rep, 33, 2020
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6M96
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![BU of 6m96 by Molmil](/molmil-images/mine/6m96) | |
8E1P
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![BU of 8e1p by Molmil](/molmil-images/mine/8e1p) | Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505-SOSIP.v4.1-GT1.2gp120, ... | 著者 | Sarkar, A, Kumar, S, Wilson, I.A. | 登録日 | 2022-08-11 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.82 Å) | 主引用文献 | Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions. Cell Rep Med, 4, 2023
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7PJE
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![BU of 7pje by Molmil](/molmil-images/mine/7pje) | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | 分子名称: | Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | 登録日 | 2021-08-24 | 公開日 | 2021-09-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
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6OC3
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![BU of 6oc3 by Molmil](/molmil-images/mine/6oc3) | |