8FOB
| Cryo-EM structure of human TRPV6 in the open state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-12-30 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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8FNR
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7Q93
| Crystal Structure of Agrobacterium tumefaciens NADQ, NAD complex. | 分子名称: | GLYCEROL, NADQ transcription factor, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Cianci, M, Minazzato, G, Heroux, A, Raffaelli, N, Sorci, L, Gasparrini, M. | 登録日 | 2021-11-11 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis. J.Struct.Biol., 214, 2022
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8FQT
| Apo ADC-219 beta-lactamase | 分子名称: | Beta-lactamase, PHOSPHATE ION | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Maurer, O.L. | 登録日 | 2023-01-06 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J.Med.Chem., 66, 2023
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7Q92
| Crystal Structure of Agrobacterium tumefaciens NADQ, ATP complex. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, NADQ transcription factor, POTASSIUM ION, ... | 著者 | Cianci, M, Minazzato, G, Heroux, A, Raffaelli, N, Sorci, L, Gasparrini, M. | 登録日 | 2021-11-11 | 公開日 | 2022-11-09 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Bacterial NadQ (COG4111) is a Nudix-like, ATP-responsive regulator of NAD biosynthesis. J.Struct.Biol., 214, 2022
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8FQP
| apo ADC-162 beta-lactamase | 分子名称: | Beta-lactamase, GLYCINE, PHOSPHATE ION | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Fernando, M.C. | 登録日 | 2023-01-06 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.419 Å) | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J.Med.Chem., 66, 2023
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7BGB
| The H/ACA RNP lobe of human telomerase | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | 著者 | Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. | 登録日 | 2021-01-06 | 公開日 | 2021-04-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure of human telomerase holoenzyme with bound telomeric DNA. Nature, 593, 2021
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8FQW
| ADC-30 in complex with boronic acid transition state inhibitor MB076 | 分子名称: | 1-[(2R)-2-{2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetamido}-2-boronoethyl]-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase, DIMETHYL SULFOXIDE, ... | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Ruiz, V.J. | 登録日 | 2023-01-06 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J.Med.Chem., 66, 2023
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7BG9
| The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate | 分子名称: | DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3'), Histone H2A, Histone H2B, ... | 著者 | Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. | 登録日 | 2021-01-06 | 公開日 | 2021-04-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure of human telomerase holoenzyme with bound telomeric DNA. Nature, 593, 2021
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7BGC
| human butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Nachon, F, Salerno, A, Bolognesi, M.L. | 登録日 | 2021-01-06 | 公開日 | 2021-04-28 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. J.Med.Chem., 64, 2021
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8FQV
| apo ADC-30 beta-lactamase | 分子名称: | Beta-lactamase, PHOSPHATE ION | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Ruiz, V.J. | 登録日 | 2023-01-06 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J.Med.Chem., 66, 2023
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8FQU
| ADC-219 in complex with boronic acid transition state inhibitor MB076 | 分子名称: | 1-[(2R)-2-{2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetamido}-2-boronoethyl]-1H-1,2,3-triazole-4-carboxylic acid, Beta-lactamase, DIMETHYL SULFOXIDE | 著者 | Powers, R.A, Wallar, B.J, June, C.M, Maurer, O.L. | 登録日 | 2023-01-06 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter -Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum. J.Med.Chem., 66, 2023
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7C27
| Glycosidase F290Y at pH4.5 | 分子名称: | AMMONIUM ION, CITRIC ACID, GLYCEROL, ... | 著者 | Tagami, T, Kikuchi, A, Okuyama, M, Kimura, A. | 登録日 | 2020-05-07 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structural insights reveal the second base catalyst of isomaltose glucohydrolase. Febs J., 289, 2022
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6QTZ
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8EXL
| Crystal structure of PI3K-alpha in complex with taselisib | 分子名称: | 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1H-pyrazol-1-yl)propanamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E. | 登録日 | 2022-10-25 | 公開日 | 2022-11-30 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.989 Å) | 主引用文献 | Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha. J.Med.Chem., 65, 2022
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6YWE
| The structure of the mitoribosome from Neurospora crassa in the P/E tRNA bound state | 分子名称: | 16S rRNA, 23S rRNA, 3-hydroxyisobutyryl-CoA hydrolase, ... | 著者 | Amunts, A, Itoh, Y, Naschberger, A. | 登録日 | 2020-04-29 | 公開日 | 2020-11-11 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi. Nat Commun, 11, 2020
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7BM6
| Structure-function analysis of a new PL17 oligoalginate lyase from the marine bacterium Zobellia galactanivorans DsijT | 分子名称: | 4-deoxy-alpha-L-erythro-hex-4-enopyranuronic acid-(1-4)-alpha-D-mannopyranuronic acid, Alginate lyase, family PL17, ... | 著者 | Czjzek, M, Roret, T, Jouanneau, D, Le Duff, N, Jeudy, A. | 登録日 | 2021-01-19 | 公開日 | 2021-07-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Structure-function analysis of a new PL17 oligoalginate lyase from the marine bacterium Zobellia galactanivorans DsijT. Glycobiology, 31, 2021
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7BHK
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7BHL
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7BCQ
| ASCT2 in the presence of the inhibitor Lc-BPE (position "up") in the outward-open conformation. | 分子名称: | 4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | 著者 | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | 登録日 | 2020-12-21 | 公開日 | 2021-09-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BCS
| ASCT2 in the presence of the inhibitor Lc-BPE (position "down") in the outward-open conformation. | 分子名称: | (2~{S},4~{S})-4-(4-phenylphenyl)carbonyloxypyrrolidine-2-carboxylic acid, Neutral amino acid transporter B(0) | 著者 | Garibsingh, R.A, Ndaru, E, Garaeva, A.A, Shi, Y, Zielewicz, L, Bonomi, M, Slotboom, D.J, Paulino, C, Grewer, C, Schlessinger, A. | 登録日 | 2020-12-21 | 公開日 | 2021-09-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Rational design of ASCT2 inhibitors using an integrated experimental-computational approach. Proc.Natl.Acad.Sci.USA, 118, 2021
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7BMK
| ATP-Competitive Partial Antagonists-'PAIR's-Rheostatically Modulate IRE1alpha's Kinase Helix-alphaC to Segregate its RNase-Mediated Biological Outputs | 分子名称: | 1,2-ETHANEDIOL, 2,2,2-tris(fluoranyl)-~{N}-[4-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]ethanesulfonamide, DI(HYDROXYETHYL)ETHER, ... | 著者 | Feldman, H.C, Ghosh, R, Auyeung, V, Mueller, J.L, Vidadala, V.N, Olivier, A, Backes, B.J, Zikherman, J, Papa, F.R, Maly, D.J. | 登録日 | 2021-01-20 | 公開日 | 2021-09-29 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | ATP-competitive partial antagonists of the IRE1 alpha RNase segregate outputs of the UPR. Nat.Chem.Biol., 17, 2021
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8FIH
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7BC2
| BAZ2A bromodomain in complex with triazole compound MS04-TN04 | 分子名称: | 2-(1-methyl-1H-1,2,3-triazol-5-yl)-5-((2-(pyridin-4-yl)pyrrolidin-1-yl)methyl)-1H-benzo[d]imidazole, Bromodomain adjacent to zinc finger domain protein 2A | 著者 | Dalle Vedove, A, Cazzanelli, G, Sedykh, M, Caflisch, A, Lolli, G. | 登録日 | 2020-12-18 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13, 2022
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8F7T
| Glycan-Base ConC Env Trimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env gp120, ... | 著者 | Olia, A.S, Kwong, P.D. | 登録日 | 2022-11-20 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases. Iscience, 26, 2023
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