7BMK

ATP-Competitive Partial Antagonists-'PAIR's-Rheostatically Modulate IRE1alpha's Kinase Helix-alphaC to Segregate its RNase-Mediated Biological Outputs

Summary for 7BMK

• Entry DOI: 10.2210/pdb7bmk/pdb
• Descriptor: Serine/threonine-protein kinase/endoribonuclease IRE1, 2,2,2-tris(fluoranyl)-~{N}-[4-[3-[2-[[(3~{S})-piperidin-3-yl]amino]pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]ethanesulfonamide, GLYCEROL, ... (7 entities in total)
• Functional Keywords: kinase, kinase inhibitor, transferase, transferase inhibitor, unknown function
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 102917.21

Authors

Feldman, H.C.,Ghosh, R.,Auyeung, V.,Mueller, J.L.,Vidadala, V.N.,Olivier, A.,Backes, B.J.,Zikherman, J.,Papa, F.R.,Maly, D.J. (deposition date: 2021-01-20, release date: 2021-09-29, Last modification date: 2024-06-19)

• Primary citation: Feldman, H.C.,Ghosh, R.,Auyeung, V.C.,Mueller, J.L.,Kim, J.H.,Potter, Z.E.,Vidadala, V.N.,Perera, B.G.K.,Olivier, A.,Backes, B.J.,Zikherman, J.,Papa, F.R.,Maly, D.J.; ATP-competitive partial antagonists of the IRE1 alpha RNase segregate outputs of the UPR.; Nat.Chem.Biol., 17:1148-1156, 2021; PubMed: 34556859; DOI: 10.1038/s41589-021-00852-0

Experimental method

X-RAY DIFFRACTION (1.85 Å)