4X0Q
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![BU of 4x0q by Molmil](/molmil-images/mine/4x0q) | |
4X0P
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3KD5
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![BU of 3kd5 by Molmil](/molmil-images/mine/3kd5) | |
3KD1
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3TAF
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![BU of 3taf by Molmil](/molmil-images/mine/3taf) | 5-fluorocytosine paired with ddGMP in RB69 gp43 | Descriptor: | DNA (5'-D(*CP*CP*(C37)P*GP*GP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*CP*CP*G)-3'), DNA-directed DNA polymerase, ... | Authors: | Zahn, K.E. | Deposit date: | 2011-08-04 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site. Biochemistry, 50, 2011
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3TAG
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![BU of 3tag by Molmil](/molmil-images/mine/3tag) | 5-fluorocytosine paired with dAMP in RB69 gp43 | Descriptor: | DNA (5'-D(*CP*CP*(C37)P*GP*GP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*CP*CP*A)-3'), DNA-directed DNA polymerase, ... | Authors: | Zahn, K.E. | Deposit date: | 2011-08-04 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site. Biochemistry, 50, 2011
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3TAE
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![BU of 3tae by Molmil](/molmil-images/mine/3tae) | 5-hydroxycytosine paired with dAMP in RB69 gp43 | Descriptor: | DNA (5'-D(*CP*CP*(5OC)P*GP*GP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*CP*CP*A)-3'), DNA polymerase, ... | Authors: | Zahn, K.E. | Deposit date: | 2011-08-04 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site. Biochemistry, 50, 2011
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3TAB
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![BU of 3tab by Molmil](/molmil-images/mine/3tab) | 5-hydroxycytosine paired with dGMP in RB69 gp43 | Descriptor: | DNA (5'-D(*CP*CP*(5OC)P*GP*GP*TP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*GP*CP*TP*GP*TP*CP*AP*TP*AP*CP*CP*G)-3'), DNA polymerase, ... | Authors: | Zahn, K.E. | Deposit date: | 2011-08-03 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The miscoding potential of 5-hydroxycytosine arises due to template instability in the replicative polymerase active site. Biochemistry, 50, 2011
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2P5G
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![BU of 2p5g by Molmil](/molmil-images/mine/2p5g) | Crystal structure of RB69 gp43 in complex with DNA with dAMP opposite an abasic site analog in a 21mer template | Descriptor: | DNA polymerase, Primer DNA, Template DNA | Authors: | Zahn, K.E, Belrhali, H, Wallace, S.S, Doublie, S. | Deposit date: | 2007-03-15 | Release date: | 2007-10-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry, 46, 2007
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2OZM
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![BU of 2ozm by Molmil](/molmil-images/mine/2ozm) | Crystal structure of RB69 gp43 in complex with DNA with 5-NITP opposite an abasic site analog | Descriptor: | 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO -1H-INDOLE, DNA polymerase, MAGNESIUM ION, ... | Authors: | Zahn, K.E, Belrhali, H, Wallace, S.S, Doublie, S. | Deposit date: | 2007-02-26 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Caught Bending the A-Rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide Biochemistry, 46, 2007
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2OZS
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![BU of 2ozs by Molmil](/molmil-images/mine/2ozs) | Crystal structure of RB69 gp43 in complex with DNA with dATP opposite dTMP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, MAGNESIUM ION, ... | Authors: | Zahn, K.E, Belrhali, H, Wallace, S.S, Doublie, S. | Deposit date: | 2007-02-27 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry, 46, 2007
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2OYQ
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![BU of 2oyq by Molmil](/molmil-images/mine/2oyq) | Crystal structure of RB69 gp43 in complex with DNA with 5-NIMP opposite an abasic site analog | Descriptor: | 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO -1H-INDOLE, DNA polymerase, MAGNESIUM ION, ... | Authors: | Zahn, K.E, Belrhali, H, Wallace, S.S, Doublie, S. | Deposit date: | 2007-02-22 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Caught bending the a-rule: crystal structures of translesion DNA synthesis with a non-natural nucleotide. Biochemistry, 46, 2007
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7RDS
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![BU of 7rds by Molmil](/molmil-images/mine/7rds) | Structure of human NTHL1 | Descriptor: | IRON/SULFUR CLUSTER, Isoform 3 of Endonuclease III-like protein 1 | Authors: | Carroll, B.L, Zahn, K.E, Doublie, S. | Deposit date: | 2021-07-11 | Release date: | 2021-12-29 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis. Nucleic Acids Res., 49, 2021
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8E23
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![BU of 8e23 by Molmil](/molmil-images/mine/8e23) | Human DNA polymerase theta in complex with allosteric inhibitor | Descriptor: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*GP*TP*CP*CP*AP*AP*TP*GP*AP*CP*AP*GP*CP*CP*GP*C)-3'), DNA (5'-D(*GP*C*GP*GP*CP*TP*GP*TP*CP*AP*TP*TP*G)-3'), ... | Authors: | Mader, P, Pau, V.P.T, Sicheri, F. | Deposit date: | 2022-08-13 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
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8E24
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![BU of 8e24 by Molmil](/molmil-images/mine/8e24) | Human DNA polymerase theta in complex with allosteric inhibitor | Descriptor: | 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-[2,4-bis(trifluoromethyl)phenyl]-N-phenyl-N-[3-(pyridazin-3-yl)prop-2-yn-1-yl]acetamide, DNA, ... | Authors: | Mader, P, Pau, V.P.T, Sicheri, F. | Deposit date: | 2022-08-13 | Release date: | 2022-09-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Identification of RP-6685 , an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol theta. J.Med.Chem., 65, 2022
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7RDT
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![BU of 7rdt by Molmil](/molmil-images/mine/7rdt) | Structure of human NTHL1 - linker 1 chimera | Descriptor: | IRON/SULFUR CLUSTER, Isoform 3 of Endonuclease III-like protein 1 | Authors: | Carroll, B.L, Doublie, S. | Deposit date: | 2021-07-11 | Release date: | 2021-12-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis. Nucleic Acids Res., 49, 2021
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