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4JHN
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BU of 4jhn by Molmil
The crystal structure of the RPGR RCC1-like domain
Descriptor: X-linked retinitis pigmentosa GTPase regulator
Authors:Waetzlich, D, Vetter, I, Wittinghofer, A, Ismail, S.
Deposit date:2013-03-05
Release date:2013-04-17
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo.
Embo Rep., 14, 2013
3FTQ
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BU of 3ftq by Molmil
Crystal structure of Septin 2 in complex with GppNHp and Mg2+
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Septin-2
Authors:Sirajuddin, M, Wittinghofer, A.
Deposit date:2009-01-13
Release date:2009-09-22
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:GTP-induced conformational changes in septins and implications for function
Proc.Natl.Acad.Sci.USA, 106, 2009
1O9E
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BU of 1o9e by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, CITRATE ANION, FUSICOCCIN
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9C
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BU of 1o9c by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, CHLORIDE ION, CITRATE ANION
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1O9D
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BU of 1o9d by Molmil
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex
Descriptor: 14-3-3-LIKE PROTEIN C, PLASMA MEMBRANE H+ ATPASE
Authors:Wurtele, M, Jelich-Ottmann, C, Wittinghofer, A, Oecking, C.
Deposit date:2002-12-12
Release date:2003-03-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex
Embo J., 22, 2003
1HE1
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BU of 1he1 by Molmil
Crystal structure of the complex between the GAP domain of the Pseudomonas aeruginosa ExoS toxin and human Rac
Descriptor: ALUMINUM FLUORIDE, EXOENZYME S, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Wurtele, M, Wolf, E, Pederson, K.J, Buchwald, G, Ahmadian, M.R, Barbieri, J.T, Wittinghofer, A.
Deposit date:2000-11-18
Release date:2001-01-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:How the Pseudomonas Aeruginosa Exos Toxin Downregulates Rac
Nat.Struct.Biol., 8, 2001
1HE9
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BU of 1he9 by Molmil
Crystal structure of the GAP domain of the Pseudomonas aeruginosa ExoS toxin
Descriptor: EXOENZYME S
Authors:Wurtele, M, Renault, L, Barbieri, J.T, Wittinghofer, A, Wolf, E.
Deposit date:2000-11-21
Release date:2001-03-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Exos Gtpase Activating Domain
FEBS Lett., 491, 2001
1IAQ
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BU of 1iaq by Molmil
C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, TRANSFORMING PROTEIN P21/H-RAS-1
Authors:Spoerner, M, Herrmann, C, Vetter, I.R, Kalbitzer, H.R, Wittinghofer, A.
Deposit date:2001-03-23
Release date:2001-06-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Dynamic properties of the Ras switch I region and its importance for binding to effectors.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K8R
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BU of 1k8r by Molmil
Crystal structure of Ras-Bry2RBD complex
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein kinase byr2, ...
Authors:Scheffzek, K, Gruenewald, P, Wohlgemuth, S, Kabsch, W, Tu, H, Wigler, M, Wittinghofer, A, Herrmann, C.
Deposit date:2001-10-25
Release date:2002-03-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure, 9, 2001
5IL7
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BU of 5il7 by Molmil
Leucine rich repeat domain of the Chlorobium tepidum Roco protein
Descriptor: Rab family protein
Authors:Gotthardt, K, Wittinghofer, A.
Deposit date:2016-03-04
Release date:2016-03-16
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.
Proc.Natl.Acad.Sci.USA, 113, 2016
2WBL
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BU of 2wbl by Molmil
Three-dimensional structure of a binary ROP-PRONE complex
Descriptor: RAC-LIKE GTP-BINDING PROTEIN ARAC2, RHO OF PLANTS GUANINE NUCLEOTIDE EXCHANGE FACTOR 8
Authors:Thomas, C, Fricke, I, Weyand, M, Berken, A.
Deposit date:2009-03-02
Release date:2009-04-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:3D Structure of a Binary Rop-Prone Complex: The Final Intermediate for a Complete Set of Molecular Snapshots of the Ropgef Reaction.
Biol.Chem., 390, 2009
4WNR
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BU of 4wnr by Molmil
Structure of methanosarcina barkeri Roco2 RocCORdC bound to GDP
Descriptor: GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich-repeat protein, ...
Authors:Terheyden, S.
Deposit date:2014-10-14
Release date:2014-11-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Revisiting the Roco G-protein cycle.
Biochem.J., 465, 2015
6XTB
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BU of 6xtb by Molmil
Subunit BBS 5 of the human core BBSome complex
Descriptor: Bardet-Biedl syndrome 5 protein
Authors:Klink, B.U, Raunser, S, Gatsogiannis, C.
Deposit date:2020-01-15
Release date:2020-02-19
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure of the human BBSome core complex.
Elife, 9, 2020
6XT9
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BU of 6xt9 by Molmil
Subunits BBS 1,4,8,9,18 of the human BBSome complex
Descriptor: BBSome-interacting protein 1, Bardet-Biedl syndrome 1 protein, Bardet-Biedl syndrome 4 protein, ...
Authors:Klink, B.U, Raunser, S, Gatsogiannis, C.
Deposit date:2020-01-15
Release date:2020-01-29
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the human BBSome core complex.
Elife, 9, 2020
1A2B
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BU of 1a2b by Molmil
HUMAN RHOA COMPLEXED WITH GTP ANALOGUE
Descriptor: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, TRANSFORMING PROTEIN RHOA
Authors:Ihara, K, Muraguchi, S, Kato, M, Shimizu, T, Shirakawa, M, Kuroda, S, Kaibuchi, K, Hakoshima, T.
Deposit date:1997-12-26
Release date:1998-06-17
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
J.Biol.Chem., 273, 1998
2K0C
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BU of 2k0c by Molmil
Zinc-finger 2 of Nup153
Descriptor: Nuclear pore complex protein Nup153, ZINC ION
Authors:Bangert, J.A, Schrader, N, Vetter, I.R, Stoll, R.
Deposit date:2008-01-31
Release date:2008-07-01
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:The Crystal Structure of the Ran-Nup153ZnF2 Complex: a General Ran Docking Site at the Nuclear Pore Complex.
Structure, 16, 2008
5UKD
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BU of 5ukd by Molmil
PH INFLUENCES FLUORIDE COORDINATION NUMBER OF THE ALFX PHOSPHORYL TRANSFER TRANSITION STATE ANALOG
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Schlichting, I, Reinstein, J.
Deposit date:1999-04-18
Release date:1999-08-14
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog.
Nat.Struct.Biol., 6, 1999
3CF6
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BU of 3cf6 by Molmil
Structure of Epac2 in complex with cyclic-AMP and Rap
Descriptor: 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, ...
Authors:Rehmann, H, Arias-Palomo, E, Hadders, M.A, Schwede, F, Llorca, O, Bos, J.L.
Deposit date:2008-03-02
Release date:2008-07-29
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Nature, 455, 2008
4UKD
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BU of 4ukd by Molmil
UMP/CMP KINASE FROM SLIME MOLD COMPLEXED WITH ADP, UDP, BERYLLIUM FLUORIDE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM DIFLUORIDE, MAGNESIUM ION, ...
Authors:Schlichting, I, Reinstein, J.
Deposit date:1997-05-20
Release date:1998-05-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative.
Biochemistry, 36, 1997
2OHF
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BU of 2ohf by Molmil
Crystal structure of human OLA1 in complex with AMPPCP
Descriptor: GTP-binding protein 9, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Marquardt, T, Kostrewa, D.
Deposit date:2007-01-10
Release date:2007-04-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human OLA1 defines an ATPase subfamily in the Obg family of GTP-binding proteins
J.Biol.Chem., 282, 2007
2QAG
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BU of 2qag by Molmil
Crystal structure of human septin trimer 2/6/7
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Septin-2, ...
Authors:Sirajuddin, M.
Deposit date:2007-06-15
Release date:2007-08-07
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insight into filament formation by mammalian septins.
Nature, 449, 2007
2CA6
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BU of 2ca6 by Molmil
MIRAS structure determination from hemihedrally twinned crystals
Descriptor: RAN GTPASE-ACTIVATING PROTEIN 1, SULFATE ION
Authors:Hillig, R.C, Renault, L.
Deposit date:2005-12-17
Release date:2006-01-11
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Detecting and Overcoming Hemihedral Twinning During the Mir Structure Determination of RNA1P.
Acta Crystallogr.,Sect.D, 62, 2006
3CH5
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BU of 3ch5 by Molmil
The crystal structure of the RanGDP-Nup153ZnF2 complex
Descriptor: Fragment of Nuclear pore complex protein Nup153, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Vetter, I.R, Schrader, N.
Deposit date:2008-03-07
Release date:2008-07-01
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of the Ran-Nup153ZnF2 Complex: a General Ran Docking Site at the Nuclear Pore Complex
Structure, 16, 2008
1RAX
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BU of 1rax by Molmil
RA-DOMAIN OF RAL GUANOSINE-NUCLEOTIDE DISSOCIATION STIMULATOR
Descriptor: PROTEIN (RA-DOMAIN OF RAL GUANOSINE DISSOCIATION STIMULATOR)
Authors:Mueller, T.D, Handel, L, Schmieder, P, Oschkinat, H.
Deposit date:1999-03-13
Release date:1999-03-19
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:High-Resolution Structure of the Ra-Domain of Human Ralgds and a Dynamics Study of its Binding Loop to Ras
To be Published
1Y64
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BU of 1y64 by Molmil
Bni1p Formin Homology 2 Domain complexed with ATP-actin
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ...
Authors:Otomo, T, Tomchick, D.R, Otomo, C, Panchal, S.C, Machius, M, Rosen, M.K.
Deposit date:2004-12-03
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain
Nature, 433, 2005

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