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Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI
Descriptor:	Coagulation factor XI, DIMETHYL SULFOXIDE, FXIA ANTIBODY FAB HEAVY CHAIN, ...
Authors:	Schaefer, M, Buchmueller, A, Dittmer, F, Strassburger, J, Wilmen, A.
Deposit date:	2018-08-27
Release date:	2019-09-11
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI. J.Mol.Biol., 431, 2019

X-ray structure of KH1-2 domain of IMP3
Descriptor:	Insulin-like growth factor 2 mRNA-binding protein 3
Authors:	Janowski, R, Schlundt, A, Sattler, M, Niessing, D.
Deposit date:	2018-06-07
Release date:	2019-04-24
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3. Nat Commun, 10, 2019

hAPC-h1573 Fab complex
Descriptor:	Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, h1573 Fab H chain, ...
Authors:	Wang, X, Wang, D, Zhao, X, Egner, U.
Deposit date:	2020-03-03
Release date:	2020-07-08
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (3.7 Å)
Cite:	Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. Nat Commun, 11, 2020

hAPC-c25k23 Fab complex
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, ...
Authors:	Wang, X, Li, L, Zhao, X, Egner, U.
Deposit date:	2020-03-03
Release date:	2020-07-08
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia. Nat Commun, 11, 2020