3PAW
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![BU of 3paw by Molmil](/molmil-images/mine/3paw) | |
2ZLF
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![BU of 2zlf by Molmil](/molmil-images/mine/2zlf) | The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase | Descriptor: | FTLDADF, Ribonucleoside-diphosphate reductase large chain 1 | Authors: | Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. | Deposit date: | 2008-04-09 | Release date: | 2008-08-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
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2ZLG
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![BU of 2zlg by Molmil](/molmil-images/mine/2zlg) | The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase | Descriptor: | (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, Ribonucleoside-diphosphate reductase large chain 1 | Authors: | Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. | Deposit date: | 2008-04-09 | Release date: | 2008-08-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
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3HNC
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![BU of 3hnc by Molmil](/molmil-images/mine/3hnc) | Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP | Descriptor: | MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, SULFATE ION, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3HNE
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![BU of 3hne by Molmil](/molmil-images/mine/3hne) | Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3HND
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![BU of 3hnd by Molmil](/molmil-images/mine/3hnd) | Crystal structure of human ribonucleotide reductase 1 bound to the effector TTP and substrate GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3HNF
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![BU of 3hnf by Molmil](/molmil-images/mine/3hnf) | Crystal structure of human ribonucleotide reductase 1 bound to the effectors TTP and dATP | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large subunit, ... | Authors: | Fairman, J.W, Wijerathna, S.R, Xu, H, Dealwis, C.G. | Deposit date: | 2009-05-31 | Release date: | 2011-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.16 Å) | Cite: | Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3TBA
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![BU of 3tba by Molmil](/molmil-images/mine/3tba) | Structure of Yeast Ribonucleotide Reductase 1 Q288A with dGTP and ADP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C. | Deposit date: | 2011-08-05 | Release date: | 2012-04-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
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3TB9
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![BU of 3tb9 by Molmil](/molmil-images/mine/3tb9) | Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP | Descriptor: | CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. | Deposit date: | 2011-08-05 | Release date: | 2012-04-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
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2WGH
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![BU of 2wgh by Molmil](/molmil-images/mine/2wgh) | Human Ribonucleotide reductase R1 subunit (RRM1) in complex with dATP and Mg. | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Welin, R.M, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kragh-Nielsen, T, Kotzsch, A, Kotenyova, T, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Schutz, P, Siponen, M.I, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Wisniewska, M, Nordlund, P. | Deposit date: | 2009-04-19 | Release date: | 2009-05-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for Allosteric Regulation of Human Ribonucleotide Reductase by Nucleotide-Induced Oligomerization. Nat.Struct.Mol.Biol., 18, 2011
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3K8T
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![BU of 3k8t by Molmil](/molmil-images/mine/3k8t) | Structure of eukaryotic rnr large subunit R1 complexed with designed adp analog compound | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2'-deoxy-2'-(2-hydroxyethyl)adenosine 5'-(trihydrogen diphosphate), GLYCEROL, ... | Authors: | Sun, D, Xu, H, Dealwis, C, Lee, R.E. | Deposit date: | 2009-10-14 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors Chemmedchem, 4, 2009
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