6Y4Y
| The crystal structure of human MACROD2 in space group P41212 | 分子名称: | L(+)-TARTARIC ACID, Thioredoxin 1,ADP-ribose glycohydrolase MACROD2 | 著者 | Wazir, S, Maksimainen, M.M, Lehtio, L. | 登録日 | 2020-02-24 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Multiple crystal forms of human MacroD2. Acta Crystallogr.,Sect.F, 76, 2020
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6Y73
| The crystal structure of human MACROD2 in space group P43 | 分子名称: | ADP-ribose glycohydrolase MACROD2, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Wazir, S, Maksimainen, M.M, Lehtio, L. | 登録日 | 2020-02-28 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Multiple crystal forms of human MacroD2. Acta Crystallogr.,Sect.F, 76, 2020
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6Y4Z
| The crystal structure of human MACROD2 in space group P43212 | 分子名称: | L(+)-TARTARIC ACID, Thioredoxin 1,ADP-ribose glycohydrolase MACROD2 | 著者 | Wazir, S, Maksimainen, M.M, Lehtio, L. | 登録日 | 2020-02-24 | 公開日 | 2020-09-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Multiple crystal forms of human MacroD2. Acta Crystallogr.,Sect.F, 76, 2020
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8TV6
| SARS-CoV-2 Mac1 in complex with MDOLL-0169 | 分子名称: | (1R,6R)-6-{[3-(methoxycarbonyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl]carbamoyl}cyclohex-3-ene-1-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Wazir, S, Maksimainen, M, Lehtio, L. | 登録日 | 2023-08-17 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target. J.Med.Chem., 2024
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8TV7
| SARS-CoV-2 Mac1 in complex with MDOLL-0229 | 分子名称: | (1R,2R)-2-{[3-(methoxycarbonyl)-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl]carbamoyl}cyclohexane-1-carboxylic acid, GLYCEROL, Papain-like protease nsp3 | 著者 | Wazir, S, Maksimainen, M, Lehtio, L. | 登録日 | 2023-08-17 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target. J.Med.Chem., 2024
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5WS7
| Crystal structure of human MTH1(G2K/C87A/C104S mutant) in complex with 2-oxo-dATP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-12-05 | 公開日 | 2017-01-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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6ILI
| Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 6.5 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2018-10-18 | 公開日 | 2018-11-07 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHI
| Crystal structure of human MTH1(G2K mutant) in complex with 8-oxo-dGTP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.211 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHO
| Crystal structure of human MTH1(G2K/D120A mutant) in complex with 8-oxo-dGTP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.191 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHN
| Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.391 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHM
| Crystal structure of human MTH1(G2K/D120N mutant) in complex with 8-oxo-dGTP at pH 7.0 | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, SODIUM ION | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHQ
| Crystal structure of human MTH1(G2K/D120A mutant) in complex with 2-oxo-dATP under high concentrations of 2-oxo-dATP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.181 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHJ
| Crystal structure of human MTH1(G2K mutant) in complex with 2-oxo-dATP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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5GHP
| Crystal structure of human MTH1(G2K/D120A mutant) in complex with 2-oxo-dATP | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SODIUM ION | 著者 | Nakamura, T, Waz, S, Hirata, K, Nakabeppu, Y, Yamagata, Y. | 登録日 | 2016-06-20 | 公開日 | 2017-01-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.192 Å) | 主引用文献 | Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity J. Biol. Chem., 292, 2017
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6IJY
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7JO8
| Crystal structure of a Chimeric Antigen Receptor (CAR) scFv domain rearrangement forming a VL-VL dimer | 分子名称: | 47G4-CD828Z, MALONATE ION, PENTAETHYLENE GLYCOL, ... | 著者 | Cheung, J, Hendrickson, W.A, Kochenderfer, J.N, Youkharibache, P. | 登録日 | 2020-08-06 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | Crystal Structure of a Chimeric Antigen Receptor (CAR) scFv Domain Rearrangement Forming a VL-VL Dimer Crystals, 13, 2023
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