8CZ7
| Crystal structure of SARS-CoV-2 Mpro with compound C2 | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-(4-methoxyphenyl)acetamide | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | 登録日 | 2022-05-24 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants. Emerg Microbes Infect, 12, 2023
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5FGZ
| E. coli PBP1b in complex with FPI-1465 | 分子名称: | MOENOMYCIN, Penicillin-binding protein 1B, [[(3~{R},6~{S})-1-methanoyl-6-[[(3~{S})-pyrrolidin-3-yl]oxycarbamoyl]piperidin-3-yl]amino] hydrogen sulfate | 著者 | King, D.T, Strynadka, N.C.J. | 登録日 | 2015-12-21 | 公開日 | 2016-01-20 | 最終更新日 | 2019-11-20 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-beta-Lactamases and Penicillin-Binding Proteins. Acs Chem.Biol., 11, 2016
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5WC3
| SpoIIIAG | 分子名称: | SpoIIIAG, Stage III sporulation engulfment assemblyprotein | 著者 | Zeytuni, N, Hong, C, Worrall, L.J, Huang, R.K, Yu, Z, Strynadka, N.C.J. | 登録日 | 2017-06-29 | 公開日 | 2017-08-16 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Near-atomic resolution cryoelectron microscopy structure of the 30-fold homooligomeric SpoIIIAG channel essential to spore formation in Bacillus subtilis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3J1X
| A refined model of the prototypical Salmonella typhimurium T3SS basal body reveals the molecular basis for its assembly | 分子名称: | Protein PrgH | 著者 | Sgourakis, N.G, Bergeron, J.R.C, Worrall, L.J, Strynadka, N.C.J, Baker, D. | 登録日 | 2012-07-10 | 公開日 | 2013-05-22 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (11.7 Å) | 主引用文献 | A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly. Plos Pathog., 9, 2013
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3J1V
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3J1W
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5CUL
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5CUK
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6PEP
| Focussed refinement of InvGN0N1:SpaPQR:PrgIJ from the Salmonella SPI-1 injectisome needle complex | 分子名称: | Protein InvG, Protein PrgH, Protein PrgI, ... | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2019-06-20 | 公開日 | 2019-10-23 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Nat Microbiol, 4, 2019
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6PEE
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6PEM
| Focussed refinement of InvGN0N1:SpaPQR:PrgHK from Salmonella SPI-1 injectisome NC-base | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2019-06-20 | 公開日 | 2019-10-23 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Nat Microbiol, 4, 2019
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6Q15
| Structure of the Salmonella SPI-1 injectisome needle complex | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2019-08-02 | 公開日 | 2019-10-23 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (5.15 Å) | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Nat Microbiol, 4, 2019
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6Q14
| Structure of the Salmonella SPI-1 injectisome NC-base | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2019-08-02 | 公開日 | 2019-10-23 | 最終更新日 | 2020-01-08 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Nat Microbiol, 4, 2019
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6Q16
| Focussed refinement of InvGN0N1:PrgHK:SpaPQR:PrgIJ from Salmonella SPI-1 injectisome NC-base | 分子名称: | Lipoprotein PrgK, Protein InvG, Protein PrgH, ... | 著者 | Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2019-08-02 | 公開日 | 2019-10-23 | 最終更新日 | 2020-01-15 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly. Nat Microbiol, 4, 2019
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8EXS
| Cryo-EM structure of S. aureus BlaR1 F284A mutant | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2022-10-25 | 公開日 | 2023-01-11 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus. Nature, 613, 2023
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8EXT
| Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2022-10-25 | 公開日 | 2023-01-11 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus. Nature, 613, 2023
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3T0T
| Crystal structure of S. aureus Pyruvate Kinase | 分子名称: | N'-[(1E)-1-(1H-benzimidazol-2-yl)ethylidene]-5-bromo-2-hydroxybenzohydrazide, PHOSPHATE ION, Pyruvate kinase | 著者 | Worrall, L.J, Vuckovic, M, Strynadka, N.C.J. | 登録日 | 2011-07-20 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase. Acs Chem.Biol., 7, 2012
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