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7WYT
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BU of 7wyt by Molmil
Crystal structures of Na+,K+-ATPase in complex with ouabain
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-05-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WYS
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BU of 7wys by Molmil
Crystal structures of Na+,K+-ATPase in complex with istaroxime
Descriptor: (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-05-04
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
3B8E
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BU of 3b8e by Molmil
Crystal structure of the sodium-potassium pump
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, MAGNESIUM ION, Na+/K+ ATPase gamma subunit transcript variant a, ...
Authors:Morth, J.P, Pedersen, P.B, Toustrup-Jensen, M.S, Soerensen, T.L.M, Petersen, J, Andersen, J.P, Vilsen, B, Nissen, P.
Deposit date:2007-11-01
Release date:2007-12-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the sodium-potassium pump.
Nature, 450, 2007
8JFZ
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BU of 8jfz by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E1.Mg2+ state.
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C.
Deposit date:2023-05-19
Release date:2023-08-09
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
8JBL
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BU of 8jbl by Molmil
Crystal structure of Na+,K+-ATPase in the E1.Mg2+ state
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C.
Deposit date:2023-05-09
Release date:2023-08-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
8JBM
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BU of 8jbm by Molmil
Crystal structure of Na+,K+-ATPase in the E1.Mn2+ state
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C.
Deposit date:2023-05-09
Release date:2023-08-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
8JBK
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BU of 8jbk by Molmil
Crystal structure of Na+,K+-ATPase in the E1.3Na+ state
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Vilsen, B, Cornelius, F, Toyoshima, C.
Deposit date:2023-05-09
Release date:2023-08-09
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of Na + ,K + -ATPase reveal the mechanism that converts the K + -bound form to Na + -bound form and opens and closes the cytoplasmic gate.
Febs Lett., 597, 2023
7Y45
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BU of 7y45 by Molmil
Cryo-EM structure of the Na+,K+-ATPase in the E2.2K+ state
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-06-14
Release date:2022-07-13
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-electron microscopy of Na + ,K + -ATPase reveals how the extracellular gate locks in the E2·2K + state.
Febs Lett., 596, 2022
7Y46
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BU of 7y46 by Molmil
Cryo-EM structure of the Na+,K+-ATPase in the E2.2K+ state after addition of ATP
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-06-14
Release date:2022-07-13
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Cryo-electron microscopy of Na + ,K + -ATPase reveals how the extracellular gate locks in the E2·2K + state.
Febs Lett., 596, 2022
3WGV
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BU of 3wgv by Molmil
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state with oligomycin
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kanai, R, Ogawa, H, Vilsen, B, Cornelius, F, Toyoshima, C.
Deposit date:2013-08-09
Release date:2013-10-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state
Nature, 502, 2013
3WGU
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BU of 3wgu by Molmil
Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Kanai, R, Ogawa, H, Vilsen, B, Cornelius, F, Toyoshima, C.
Deposit date:2013-08-09
Release date:2013-10-09
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state
Nature, 502, 2013
7WYZ
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BU of 7wyz by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by ATP with ouabain
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WYU
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BU of 7wyu by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by ATP
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WZ0
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BU of 7wz0 by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate with ouabain
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WYY
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BU of 7wyy by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate with istaroxime
Descriptor: (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WYX
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BU of 7wyx by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by ATP with istaroxime
Descriptor: (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WYV
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BU of 7wyv by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by ATP in the presence of 40 mM Mg2+
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7WYW
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BU of 7wyw by Molmil
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by inorganic phosphate
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C.
Deposit date:2022-02-16
Release date:2022-04-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids.
Proc.Natl.Acad.Sci.USA, 119, 2022
7D94
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BU of 7d94 by Molmil
Crystal Structure of the Na+,K+-ATPase in the E2P state with bound one Mg2+ and one Rb+ in the presence of bufalin
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2020-10-12
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
Proc.Natl.Acad.Sci.USA, 118, 2021
7DDF
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BU of 7ddf by Molmil
Crystal structures of Na+,K+-ATPase in complex with beryllium fluoride
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2020-10-29
Release date:2021-01-27
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (4.62 Å)
Cite:Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
Proc.Natl.Acad.Sci.USA, 118, 2021
7D91
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BU of 7d91 by Molmil
Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ (P4(3)2(1)2 symmetry)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2020-10-12
Release date:2021-01-27
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
Proc.Natl.Acad.Sci.USA, 118, 2021
7DDL
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BU of 7ddl by Molmil
Crystal structures of Na+,K+-ATPase in complex with bufalin
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2020-10-29
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
Proc.Natl.Acad.Sci.USA, 118, 2021
7D92
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BU of 7d92 by Molmil
Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain (P4(3)2(1)2 symmetry)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2020-10-12
Release date:2021-01-27
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
Proc.Natl.Acad.Sci.USA, 118, 2021
7DDH
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BU of 7ddh by Molmil
Crystal structures of Na+,K+-ATPase in complex with digoxin
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2020-10-29
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.46 Å)
Cite:Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
Proc.Natl.Acad.Sci.USA, 118, 2021
7D93
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BU of 7d93 by Molmil
Crystal Structure of the Na+,K+-ATPase in the E2P state with bound Mg2+ and anthroylouabain (P2(1)2(1)2(1) symmetry)
Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kanai, R, Cornelius, F, Ogawa, H, Motoyama, K, Vilsen, B, Toyoshima, C.
Deposit date:2020-10-12
Release date:2021-01-27
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Binding of cardiotonic steroids to Na + ,K + -ATPase in the E2P state.
Proc.Natl.Acad.Sci.USA, 118, 2021

 

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