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Crystal Structure of 1,3,6,8-Tetrahydroxynaphthalene Synthase (THNS) from Streptomyces coelicolor A3(2): a Bacterial Type III Polyketide Synthase (PKS) Provides Insights into Enzymatic Control of Reactive Polyketide Intermediates
Descriptor:	GLYCEROL, POLYETHYLENE GLYCOL (N=34), putative polyketide synthase
Authors:	Austin, M.B, Izumikawa, M, Bowman, M.E, Udwary, D.W, Ferrer, J.L, Moore, B.S, Noel, J.P.
Deposit date:	2004-07-13
Release date:	2004-09-14
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.22 Å)
Cite:	Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates J.Biol.Chem., 279, 2004

Crystal structure of CEP250 bound to FKBP12 in the presence of FK506-like novel natural product
Descriptor:	(3R,4E,7E,10R,11S,12R,13S,16R,17R,24aS)-11,17-dihydroxy-10,12,16-trimethyl-3-[(2R)-1-phenylbutan-2-yl]-6,9,10,11,12,13,14,15,16,17,22,23,24,24a-tetradecahydro-3H-13,17-epoxypyrido[2,1-c][1,4]oxazacyclohenicosine-1,18,19(21H)-trione, 1,2-ETHANEDIOL, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ...
Authors:	Lee, S.-J, Shigdel, U.K, Townson, S.A, Verdine, G.L.
Deposit date:	2019-04-26
Release date:	2020-04-29
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface. Proc.Natl.Acad.Sci.USA, 117, 2020