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6AML
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BU of 6aml by Molmil
Phosphotriesterase variant S8
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-08-09
Release date:2018-08-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Phosphotriesterase variant S8
To Be Published
6B2F
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BU of 6b2f by Molmil
Phosphotriesterase variant S5 + TS analogue
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Phosphotriesterase, ZINC ION, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-09-20
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.775 Å)
Cite:Phosphotriesterase variant S5 + TS analogue
To Be Published
6BH7
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BU of 6bh7 by Molmil
Phosphotriesterase variant R18+254S
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-10-30
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Phosphotriesterase variant R18+254S
To Be Published
6BHK
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BU of 6bhk by Molmil
Phosphotriesterase variant R18deltaL7
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Phosphotriesterase, ZINC ION
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-10-30
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Phosphotriesterase variant R18deltaL7
To Be Published
6BHL
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BU of 6bhl by Molmil
Phosphotriesterase variant S5deltaL7
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-10-30
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Phosphotriesterase variant S5deltaL7
To Be Published
5W6B
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BU of 5w6b by Molmil
Phosphotriesterase variant S1
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-06-16
Release date:2018-12-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.739 Å)
Cite:Phosphotriesterase variant S1
To Be Published
5WCW
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BU of 5wcw by Molmil
Phosphotriesterase variant S3
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-07-02
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.457 Å)
Cite:Phosphotriesterase variant S4
To Be Published
5WCQ
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BU of 5wcq by Molmil
Phosphotriesterase variant S2
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-07-01
Release date:2018-07-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.576 Å)
Cite:Phosphotriesterase variant S2
To Be Published
5WJ0
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BU of 5wj0 by Molmil
Phosphotriesterase variant S5+254R
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-07-21
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Phosphotriesterase variant S5+254R
To Be Published
5WCP
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BU of 5wcp by Molmil
Phosphotriesterase variant S7
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-07-01
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Phosphotriesterase variant S7
To Be Published
5WMS
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BU of 5wms by Molmil
Phosphotriesterase variant S7
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-07-31
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Phosphotriesterase variant S7
To Be Published
5WCR
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BU of 5wcr by Molmil
Phosphotriesterase variant R0deltaL7
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R0, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-07-01
Release date:2019-01-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Phosphotriesterase variant R0deltaL7
To Be Published
5WIZ
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BU of 5wiz by Molmil
Phosphotriesterase variant S5
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase, ...
Authors:Miton, C.M, Campbell, E.C, Jackson, C.J, Tokuriki, N.
Deposit date:2017-07-21
Release date:2019-01-23
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Phosphotriesterase variant S5
To Be Published
8EKG
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BU of 8ekg by Molmil
MHETase variant Thr159Val, Met192Tyr, Tyr252Phe, Tyr503Trp
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Saunders, J.W, Frkic, R.L, Jackson, C.J.
Deposit date:2022-09-20
Release date:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:MHETase protein engineering using a novel colorimetric assay
To Be Published
5EHT
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BU of 5eht by Molmil
Indirect contributions of mutations underlie optimization of new enzyme function
Descriptor: GLYCEROL, N-acyl homoserine lactonase, ZINC ION
Authors:Jackson, C.J, Hong, N.-S.
Deposit date:2015-10-28
Release date:2016-09-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
Biochemistry, 55, 2016
5JQJ
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BU of 5jqj by Molmil
Directed evolutionary changes in MBL super family - NDM-1 Round 10 crystal-1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, Metallo-beta-lactamase type 2, ...
Authors:Hong, N.-S, Jackson, C.J, Carr, P.D.
Deposit date:2016-05-05
Release date:2017-05-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Enzyme evolvability is contingent on the initial sequence background
To Be Published
5K4M
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BU of 5k4m by Molmil
Directed evolutionary changes in MBL super family - NDM-1 Round 10 crystal-3
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, Metallo-beta-lactamase type 2, ...
Authors:Hong, N.-S, Jackson, C.J, Carr, P.D.
Deposit date:2016-05-20
Release date:2017-04-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Enzyme evolvability is contingent on the initial sequence background
To Be Published
3A4J
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BU of 3a4j by Molmil
arPTE (K185R/D208G/N265D/T274N)
Descriptor: 1,2-ETHANEDIOL, COBALT (II) ION, Phosphotriesterase
Authors:Foo, J.L, Jackson, C.J, Carr, P.D, Ollis, D.L.
Deposit date:2009-07-07
Release date:2010-01-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase
Proc.Natl.Acad.Sci.USA, 2009
6BM9
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BU of 6bm9 by Molmil
Directed evolutionary changes in MBL super family - VIM-2 Round 10
Descriptor: GLYCEROL, Metallo-beta-lactamase, ZINC ION
Authors:Hong, N.-S, Jackson, C.J, Carr, P.D.
Deposit date:2017-11-13
Release date:2018-11-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes.
Elife, 8, 2019
6WUP
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BU of 6wup by Molmil
Crystal structure of an ancestral cyclohexadienyl dehydratase, AncCDT-5
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ancestral cyclohexadienyl dehydratase, AncCDT-5, ...
Authors:Kaczmarski, J.A, Mahawaththa, M.C.
Deposit date:2020-05-05
Release date:2020-05-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme.
Nat Commun, 11, 2020
6BWH
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BU of 6bwh by Molmil
Crystal structure of Mycoibacterium tuberculosis Rv2983 in complex with PEP
Descriptor: 2-phospho-L-lactate guanylyltransferase, MAGNESIUM ION, PHOSPHOENOLPYRUVATE
Authors:Bashiri, G, Jirgis, E.N.M, Baker, E.N.
Deposit date:2017-12-15
Release date:2018-12-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:A revised biosynthetic pathway for the cofactor F420in prokaryotes.
Nat Commun, 10, 2019
6BQE
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BU of 6bqe by Molmil
Low-resolution structure of cyclohexadienyl dehydratase from Pseudomonas aeruginosa in space group P4322.
Descriptor: ACETATE ION, Arogenate dehydratase
Authors:Clifton, B.E, Carr, P.D, Jackson, C.J.
Deposit date:2017-11-27
Release date:2017-12-13
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein.
Nat. Chem. Biol., 14, 2018
6BWG
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BU of 6bwg by Molmil
Crystal structure of native Rv2983 from Mycobacterium tuberculosis
Descriptor: 2-phospho-L-lactate guanylyltransferase
Authors:Bashiri, G, Jirgis, E.N.M, Baker, E.N.
Deposit date:2017-12-15
Release date:2018-12-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:A revised biosynthetic pathway for the cofactor F420in prokaryotes.
Nat Commun, 10, 2019
5TUJ
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BU of 5tuj by Molmil
Ancestral Cationic Amino Acid Solute Binding Protein (AncCDT-1)
Descriptor: Ancestral protein CDT-Anc1
Authors:Kaczmarski, J.A, Clifton, B.E, Carr, P.D, Jackson, C.J.
Deposit date:2016-11-06
Release date:2017-12-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.352 Å)
Cite:Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein.
Nat. Chem. Biol., 14, 2018
5WJP
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BU of 5wjp by Molmil
Crystal structure of the cyclohexadienyl dehydratase-like solute-binding protein SAR11_1068 from Candidatus Pelagibacter ubique.
Descriptor: Cyclohexadienyl dehydratase
Authors:Clifton, B.E, Jackson, C.J.
Deposit date:2017-07-24
Release date:2017-08-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein.
Nat. Chem. Biol., 14, 2018
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