4Q1U
| Serum paraoxonase-1 by directed evolution with the K192Q mutation | 分子名称: | BROMIDE ION, CALCIUM ION, CHLORIDE ION, ... | 著者 | Ben-David, M, Sussman, J.L, Tawfik, D.S. | 登録日 | 2014-04-04 | 公開日 | 2015-02-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Catalytic stimulation by restrained active-site floppiness-the case of high density lipoprotein-bound serum paraoxonase-1. J.Mol.Biol., 427, 2015
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5HQ3
| Stable, high-expression variant of human acetylcholinesterase | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Acetylcholinesterase, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP | 著者 | Goldenzweig, A, Goldsmith, M, Hill, S.E, Gertman, O, Laurino, P, Ashani, Y, Dym, O, Albeck, S, Unger, T, Prilusky, J, Lieberman, R.L, Aharoni, A, Silman, I, Sussman, J.L, Tawfik, D.S, Fleishman, S.J. | 登録日 | 2016-01-21 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability. Mol.Cell, 63, 2016
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2BJM
| SPE7:Anthrone Complex | 分子名称: | ANTHRONE, IGE SPE7 HEAVY CHAIN, IGE SPE7 LIGHT CHAIN | 著者 | James, L.C, Tawfik, D.S. | 登録日 | 2005-02-04 | 公開日 | 2005-08-18 | 最終更新日 | 2013-10-30 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structure and Kinetics of a Transient Antibody Binding Intermediate Reveal a Kinetic Discrimination Mechanism in Antigen Recognition Proc.Natl.Acad.Sci.USA, 102, 2005
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4E3T
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6MS8
| Crystal Structure of Chalcone Isomerase from Medicago Truncatula Complexed with (2S) Naringenin | 分子名称: | Chalcone-flavonone isomerase family protein, NARINGENIN | 著者 | Burke, J.R, La Clair, J.J, Philippe, R.N, Pabis, A, Jez, J.M, Cortina, G, Kaltenbach, M, Bowman, M.E, Woods, K.B, Nelson, A.T, Tawfik, D.S, Kamerlin, S.C.L, Noel, J.P. | 登録日 | 2018-10-16 | 公開日 | 2019-08-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases Acs Catalysis, 2019
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3A3W
| Structure of OpdA mutant (G60A/A80V/S92A/R118Q/K185R/Q206P/D208G/I260T/G273S) with diethyl 4-methoxyphenyl phosphate bound in the active site | 分子名称: | COBALT (II) ION, DIETHYL 4-METHOXYPHENYL PHOSPHATE, Phosphotriesterase | 著者 | Ollis, D.L, Tawfik, D.S, Schenk, G, Jackson, C.J, Foo, J.L, Tokuriki, N, Afriat, L, Carr, P.D, Kim, H.K. | 登録日 | 2009-06-23 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase Proc.Natl.Acad.Sci.USA, 2009
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3A3X
| Structure of OpdA mutant (G60A/A80V/R118Q/K185R/Q206P/D208G/I260T/G273S) | 分子名称: | COBALT (II) ION, Phosphotriesterase | 著者 | Ollis, D.L, Tawfik, D.S, Schenk, G, Jackson, C.J, Foo, J.L, Tokuriki, N, Afriat, L, Carr, P.D, Kim, H.K. | 登録日 | 2009-06-23 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase Proc.Natl.Acad.Sci.USA, 2009
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5C2M
| The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | Predicted protein | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
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5C2N
| The de novo evolutionary emergence of a symmetrical protein is shaped by folding constraints | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta propeller | 著者 | Smock, R.G, Yadid, I, Dym, O, Clarke, J, Tawfik, D.S. | 登録日 | 2015-06-16 | 公開日 | 2016-01-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. Cell, 164, 2016
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7MFT
| Glutamate synthase, glutamate dehydrogenase counter-enzyme complex (GudB6-GltA6-GltB6) | 分子名称: | FE3-S4 CLUSTER, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Jayaraman, V, Lee, D.J, Elad, N, Fraser, J.S, Tawfik, D.S. | 登録日 | 2021-04-11 | 公開日 | 2022-01-05 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis. Nat.Chem.Biol., 18, 2022
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7MFM
| Glutamate synthase, glutamate dehydrogenase counter-enzyme complex | 分子名称: | FE3-S4 CLUSTER, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Jayaraman, V, Lee, D.J, Elad, N, Fraser, J.S, Tawfik, D.S. | 登録日 | 2021-04-10 | 公開日 | 2022-01-05 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | 主引用文献 | A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis. Nat.Chem.Biol., 18, 2022
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1V04
| serum paraoxonase by directed evolution | 分子名称: | CALCIUM ION, PHOSPHATE ION, SERUM PARAOXONASE/ARYLESTERASE 1 | 著者 | Harel, M, Aharoni, A, Gaidukov, L, Brumshtein, B, Khersonsky, O, Yagur, S, Meged, R, Dvir, H, Ravelli, R.B.G, McCarthy, A, Toker, L, Silman, I, Sussman, J.L, Tawfik, D.S. | 登録日 | 2004-03-22 | 公開日 | 2004-04-23 | 最終更新日 | 2017-03-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure and Evolution of the Serum Paraoxonase Family of Detoxifying and Anti-Atherosclerotic Enzymes Nat.Struct.Mol.Biol., 11, 2004
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6CJO
| Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95S mutation. | 分子名称: | Chalcone--flavonone isomerase 1, SULFATE ION | 著者 | Burke, J.R, La Clair, J.J, Philippe, R.N, Pabis, A, Jez, J.M, Cortina, G, Kaltenbach, M, Bowman, M.E, Woods, K.B, Nelson, A.T, Tawfik, D.S, Kamerlin, S.C.L, Noel, J.P. | 登録日 | 2018-02-26 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases Acs Catalysis, 2019
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6CJN
| Crystal Structure of Chalcone Isomerase from Medicago Sativa with the G95T mutation | 分子名称: | Chalcone--flavonone isomerase 1, SULFATE ION | 著者 | Burke, J.R, La Clair, J.J, Philippe, R.N, Pabis, A, Jez, J.M, Cortina, G, Kaltenbach, M, Bowman, M.E, Woods, K.B, Nelson, A.T, Tawfik, D.S, Kamerlin, S.C.L, Noel, J.P. | 登録日 | 2018-02-26 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases Acs Catalysis, 2019
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3GKL
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3GJN
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3IIV
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3IIO
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3IIP
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3KIH
| The crystal structures of two fragments truncated from 5-bladed beta-propeller lectin, tachylectin-2 (Lib2-D2-15) | 分子名称: | 2-(acetylamido)-2-deoxy-D-glucono-1,5-lactone, 5-bladed beta-propeller lectin | 著者 | Dym, O, Tawfik, D.S, Yadid, I, Israel Structural Proteomics Center (ISPC) | 登録日 | 2009-11-02 | 公開日 | 2010-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Metamorphic proteins mediate evolutionary transitions of structure Proc.Natl.Acad.Sci.USA, 107, 2010
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3KIF
| The crystal structures of two fragments truncated from 5-bladed beta-propeller lectin, tachylectin-2 (Lib1-B7-18 and Lib2-D2-15) | 分子名称: | 2-(acetylamido)-2-deoxy-D-glucono-1,5-lactone, 5-bladed beta-propeller lectin, SULFATE ION | 著者 | Dym, O, Tawfik, D.S, Yadid, I, Israel Structural Proteomics Center (ISPC) | 登録日 | 2009-11-02 | 公開日 | 2010-04-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Metamorphic proteins mediate evolutionary transitions of structure Proc.Natl.Acad.Sci.USA, 107, 2010
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3SRG
| Serum paraoxonase-1 by directed evolution at pH 6.5 in complex with 2-hydroxyquinoline | 分子名称: | BROMIDE ION, CALCIUM ION, CHLORIDE ION, ... | 著者 | Ben David, M, Elias, M, Silman, I, Sussman, J.L, Tawfik, D.S. | 登録日 | 2011-07-07 | 公開日 | 2012-03-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. J.Mol.Biol., 418, 2012
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3SRE
| Serum paraoxonase-1 by directed evolution at pH 6.5 | 分子名称: | BROMIDE ION, CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, ... | 著者 | Ben David, M, Elias, M, Silman, I, Sussman, J.L, Tawfik, D.S. | 登録日 | 2011-07-07 | 公開日 | 2012-03-21 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. J.Mol.Biol., 418, 2012
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3UYC
| Designed protein KE59 R8_2/7A | 分子名称: | Kemp eliminase KE59 R8_2/7A, PHOSPHATE ION | 著者 | Khersonsky, O, Kiss, G, Roethlisberger, D, Dym, O, Albeck, S, Houk, K.N, Baker, D, Tawfik, D.S, Israel Structural Proteomics Center (ISPC) | 登録日 | 2011-12-06 | 公開日 | 2012-06-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59. Proc.Natl.Acad.Sci.USA, 109, 2012
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3UXD
| Designed protein KE59 R1 7/10H with dichlorobenzotriazole (DBT) | 分子名称: | 5,7-dichloro-1H-benzotriazole, Kemp eliminase KE59 R1 7/10H, PHOSPHATE ION | 著者 | Khersonsky, O, Kiss, G, Roethlisberger, D, Dym, O, Albeck, S, Houk, K.N, Baker, D, Tawfik, D.S, Israel Structural Proteomics Center (ISPC) | 登録日 | 2011-12-05 | 公開日 | 2012-06-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59. Proc.Natl.Acad.Sci.USA, 109, 2012
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