1DLH
 
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5ISZ
 | | Crystal structure of LS01-TCR/M1-HLA-A*02 complex | | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | 著者 | Stern, L.J, Selin, L.K, Song, I. | | 登録日 | 2016-03-15 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8(+) T cell epitope.
Nat. Struct. Mol. Biol., 24, 2017
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5JHD
 | | Crystal structure of LS10-TCR/M1-HLA-A*02 complex | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | | 著者 | Stern, L.J, Selin, L.K, Song, I. | | 登録日 | 2016-04-20 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8(+) T cell epitope.
Nat. Struct. Mol. Biol., 24, 2017
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6MGQ
 | | ERAP1 in the open conformation bound to 10mer phosphinic inhibitor DG014 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 1, Phosphinic inhibitor DG014, ... | | 著者 | Stern, L.J, Maben, Z. | | 登録日 | 2018-09-14 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
Nat Commun, 12, 2021
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6NCA
 | | HLA-A2 (A*02:01) bound to a peptide from the Epstein-Barr virus BRLF1 protein | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | | 著者 | Stern, L.J, Selin, L.K, Song, I.Y. | | 登録日 | 2018-12-11 | | 公開日 | 2019-10-23 | | 最終更新日 | 2020-01-29 | | 実験手法 | X-RAY DIFFRACTION (3.300001 Å) | | 主引用文献 | CDR3 alpha drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection.
Plos Pathog., 15, 2019
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1AQD
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1AF4
 | | CRYSTAL STRUCTURE OF SUBTILISIN CARLSBERG IN ANHYDROUS DIOXANE | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, SUBTILISIN CARLSBERG | | 著者 | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | 登録日 | 1997-03-21 | | 公開日 | 1997-06-16 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrile.
Proc.Natl.Acad.Sci.USA, 94, 1997
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1BFK
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1BE8
 | | TRANS-CINNAMOYL-SUBTILISIN IN WATER | | 分子名称: | CALCIUM ION, PHENYLETHYLENECARBOXYLIC ACID, SUBTILISIN CARLSBERG | | 著者 | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | 登録日 | 1998-05-20 | | 公開日 | 1998-10-28 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.
Proc.Natl.Acad.Sci.USA, 95, 1998
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1BFU
 | | SUBTILISIN CARLSBERG IN 20% DIOXANE | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, CALCIUM ION, SUBTILISIN CARLSBERG | | 著者 | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | 登録日 | 1998-05-22 | | 公開日 | 1998-10-28 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Organic solvent binding to crystalline subtilisin1 in mostly aqueous media and in the neat solvents.
Biochem.Biophys.Res.Commun., 248, 1998
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1BE6
 | | TRANS-CINNAMOYL-SUBTILISIN IN ANHYDROUS ACETONITRILE | | 分子名称: | ACETONITRILE, CALCIUM ION, PHENYLETHYLENECARBOXYLIC ACID, ... | | 著者 | Schmitke, J.L, Stern, L.J, Klibanov, A.M. | | 登録日 | 1998-05-20 | | 公開日 | 1998-10-14 | | 最終更新日 | 2023-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Comparison of x-ray crystal structures of an acyl-enzyme intermediate of subtilisin Carlsberg formed in anhydrous acetonitrile and in water.
Proc.Natl.Acad.Sci.USA, 95, 1998
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6EA4
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5UV6
 | | Crystal structure of human Opioid Binding Protein/Cell Adhesion Molecule Like (OPCML) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Opioid-binding protein/cell adhesion molecule, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Birtley, J.R, Stern, L.J, Gabra, H, Zanini, E. | | 登録日 | 2017-02-19 | | 公開日 | 2018-03-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.65002 Å) | | 主引用文献 | Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions.
Nat Commun, 10, 2019
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5J44
 | | Crystal structure of the Secreted Extracellular protein A (SepA) from Shigella flexneri | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Serine protease SepA autotransporter | | 著者 | Birtley, J.R, Stern, L.J, McCormick, B, Maldonado-Contreras, A. | | 登録日 | 2016-03-31 | | 公開日 | 2017-04-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.912 Å) | | 主引用文献 | Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation.
Gut Microbes, 8, 2017
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1SEB
 | | COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB | | 分子名称: | ENDOGENOUS PEPTIDE MODEL, POLY-ALA, ENTEROTOXIN TYPE B, ... | | 著者 | Jardetzky, T.S, Brown, J.H, Gorga, J.C, Stern, L.J, Urban, R.G, Chi, Y.I, Stauffacher, C, Strominger, J.L, Wiley, D.C. | | 登録日 | 1995-11-26 | | 公開日 | 1996-06-20 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.
Nature, 368, 1994
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1SJH
 | | HLA-DR1 complexed with a 13 residue HIV capsid peptide | | 分子名称: | Enterotoxin type C-3, GAG polyprotein, HLA class II histocompatibility antigen, ... | | 著者 | Zavala-Ruiz, Z, Strug, I, Walker, B.D, Norris, P.J, Stern, L.J. | | 登録日 | 2004-03-03 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Proc.Natl.Acad.Sci.Usa, 101, 2004
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1T5X
 | | HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2 | | 分子名称: | 15-mer peptide fragment of Regulatory protein MIG1, Enterotoxin type C-3, HLA class II histocompatibility antigen, ... | | 著者 | Zavala-Ruiz, Z, Strug, I, Anderson, M.W, Gorski, J, Stern, L.J. | | 登録日 | 2004-05-05 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Chem.Biol., 11, 2004
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1T5W
 | | HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) | | 分子名称: | 15-mer peptide fragment of Regulatory protein MIG1, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Zavala-Ruiz, Z, Strug, I, Anderson, M.W, Gorski, J, Stern, L.J. | | 登録日 | 2004-05-05 | | 公開日 | 2004-08-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Chem.Biol., 11, 2004
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6M8P
 | | Human ERAP1 bound to phosphinic pseudotripeptide inhibitor DG013 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Endoplasmic reticulum aminopeptidase 1, Nalpha-[(2S)-2-{[[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]methyl}-4-methylpentanoyl]-L-tryptophanamide, ... | | 著者 | Maben, Z, Stern, L.J. | | 登録日 | 2018-08-22 | | 公開日 | 2019-12-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
Nat Commun, 12, 2021
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1I5I
 | | THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN | | 分子名称: | (GAMMA-B) CRYSTALLIN | | 著者 | Zarutskie, J.A, Asherie, N, Pande, J, Pande, A, Lomakin, J, Lomakin, A, Ogun, O, Stern, L.J, King, J.A, Benedek, G.B. | | 登録日 | 2001-02-27 | | 公開日 | 2001-03-07 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Enhanced crystallization of the Cys18 to Ser mutant of bovine gammaB crystallin.
J.Mol.Biol., 314, 2001
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2IPK
 | | Crystal Structure of the MHC Class II Molecule HLA-DR1 in Complex with the Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine) and the Superantigen, SEC3 Variant 3B2 | | 分子名称: | Enterotoxin type C-3, HA related Fluorogenic Peptide, AcPKXVKQNTLKLAT (X=3-[5-(dimethylamino)-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl]-L-alanine), ... | | 著者 | Nguyen, T.T, Stern, L.J. | | 登録日 | 2006-10-12 | | 公開日 | 2007-03-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells.
Nat.Chem.Biol., 3, 2007
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6DIG
 | | Crystal structure of DQA1*01:02/DQB1*06:02 in complex with a hypocretin peptide | | 分子名称: | 13-mer peptide: ALA-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-LEU-GLY-LYS, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Birtley, J.R, Stern, L.J, Mellins, E.D, Jiang, W. | | 登録日 | 2018-05-23 | | 公開日 | 2019-05-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | In vivo clonal expansion and phenotypes of hypocretin-specific CD4+T cells in narcolepsy patients and controls.
Nat Commun, 10, 2019
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4OV5
 | | Structure of HLA-DR1 with a bound peptide with non-optimal alanine in the P1 pocket | | 分子名称: | HLA class I histocompatibility antigen, A-2 alpha chain, HLA class II histocompatibility antigen, ... | | 著者 | Trenh, P, Yin, L, Stern, L.J. | | 登録日 | 2014-02-20 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | | 主引用文献 | Susceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with Peptide.
J.Biol.Chem., 289, 2014
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4P46
 | | J809.B5 Y31A TCR bound to IAb3K | | 分子名称: | 3K Peptide,H-2 class II histocompatibility antigen, A beta chain, H-2 class II histocompatibility antigen, ... | | 著者 | Stadinski, B.D, Huseby, E.S, Trenh, P, Stern, L.J. | | 登録日 | 2014-03-11 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.851 Å) | | 主引用文献 | Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.
J Immunol., 192, 2014
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4P5T
 | | 14.C6 TCR complexed with MHC class II I-Ab/3K peptide | | 分子名称: | H-2 class II histocompatibility antigen, A-B alpha chain, Human nkt tcr beta chain, ... | | 著者 | Trenh, P, Stadinski, B, Huseby, E.S, Stern, L.J. | | 登録日 | 2014-03-19 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.263 Å) | | 主引用文献 | Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.
J Immunol., 192, 2014
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