7I8C
 
 | | Crystal Structure of 54b bound to CK2a | | Descriptor: | 5-({2-[4-({[3-chloro-4-(trifluoromethoxy)phenyl]methyl}amino)butoxy]ethyl}amino)benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8H
 | | Crystal Structure of 58b bound to CK2a | | Descriptor: | 5-({(2R)-1-[4-({[3-chloro-4-(trifluoromethoxy)phenyl]methyl}amino)butoxy]propan-2-yl}amino)benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.39 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I7Z
 | | Crystal Structure of 31 bound to CK2a | | Descriptor: | 5-({2-[(4-{[(2-chloro[1,1'-biphenyl]-4-yl)methyl]amino}butyl)amino]ethyl}amino)-N-hydroxybenzo[c][2,6]naphthyridine-8-carboxamide, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8E
 | | Crystal Structure of 58d bound to CK2a | | Descriptor: | 5-{3-[4-({[3-chloro-4-(trifluoromethoxy)phenyl]methyl}amino)butoxy]azetidin-1-yl}benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8J
 | | Crystal Structure of 61g bound to CK2a | | Descriptor: | 5-{2-[4-({[4-chloro-3-(trifluoromethoxy)phenyl]methyl}amino)butoxy]ethoxy}benzo[c][2,6]naphthyridine-8-carboxylic acid, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.598 Å) | | Cite: | Anti-tumor Efficacy of CK2a; inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8Q
 | | Crystal Structure of 54l bound to CK2a | | Descriptor: | 5-[(2-{4-[({3-[(1,3-oxazol-5-yl)methyl]-5-(trifluoromethoxy)phenyl}methyl)amino]butoxy}ethyl)amino]benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8D
 | | Crystal Structure of 61a bound to CK2a | | Descriptor: | 5-{2-[4-({[3-chloro-4-(trifluoromethoxy)phenyl]methyl}amino)butoxy]ethoxy}benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8A
 | | Crystal Structure of 54f bound to CK2a | | Descriptor: | 5-({2-[4-({[3-fluoro-4-(trifluoromethoxy)phenyl]methyl}amino)butoxy]ethyl}amino)benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I85
 | | Crystal Structure of 49 bound to CK2a | | Descriptor: | 5-(ethylamino)benzo[c][2,6]naphthyridine-8-carboxamide, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.44 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I89
 | | Crystal Structure of 54a bound to CK2a | | Descriptor: | 5-{[2-(4-{[(3-chlorophenyl)methyl]amino}butoxy)ethyl]amino}benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8L
 | | Crystal Structure of 61c bound to CK2a | | Descriptor: | 5-{2-[4-({[3-methyl-4-(trifluoromethoxy)phenyl]methyl}amino)butoxy]ethoxy}-1,4-dihydrobenzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8O
 | | Crystal Structure of 18 bound to CK2a | | Descriptor: | 5-({2-[(4-{[(2-chloro[1,1'-biphenyl]-4-yl)methyl]amino}butyl)amino]ethyl}amino)benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8P
 | | Crystal Structure of 21 bound to CK2a | | Descriptor: | 5-({3-[(4-{[(2-chloro[1,1'-biphenyl]-4-yl)methyl]amino}butyl)amino]propyl}amino)benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I82
 | | Crystal Structure of 20 bound to CK2a | | Descriptor: | 5-({2-[(3-{[(2-chloro[1,1'-biphenyl]-4-yl)methyl]amino}propyl)amino]ethyl}amino)benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8B
 | | Crystal Structure of 54b bound to CK2a | | Descriptor: | 5-{[2-(4-{[(3-chloro-4-cyclopropylphenyl)methyl]amino}butoxy)ethyl]amino}benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I87
 | | Crystal Structure of 44 bound to CK2a | | Descriptor: | 5-{[2-(4-{[(2-chloro[1,1'-biphenyl]-4-yl)methyl]amino}butoxy)ethyl]amino}benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I7Y
 | | Crystal Structure of 30 bound to CK2a | | Descriptor: | 5-({2-[(4-{[(2-chloro[1,1'-biphenyl]-4-yl)methyl]amino}butyl)amino]ethyl}amino)benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I83
 | | Crystal Structure of 33 bound to CK2a | | Descriptor: | ACETATE ION, Casein kinase II subunit alpha, N~1~-[(2-chloro[1,1'-biphenyl]-4-yl)methyl]-N~4~-(2-{[(8P)-8-(1H-tetrazol-5-yl)benzo[c][2,6]naphthyridin-5-yl]amino}ethyl)butane-1,4-diamine | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8I
 | | Crystal Structure of 61b bound to CK2a | | Descriptor: | 5-{2-[4-({[3-fluoro-4-(trifluoromethoxy)phenyl]methyl}amino)butoxy]ethoxy}benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8F
 | | Crystal Structure of 58e bound to CK2a | | Descriptor: | 5-{(3R)-3-[3-({[3-chloro-4-(trifluoromethoxy)phenyl]methyl}amino)propoxy]pyrrolidin-1-yl}benzo[c][2,6]naphthyridine-8-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8M
 | | Crystal Structure of 14 bound to CK2a | | Descriptor: | 4-{[3-({N-[(2-chloro[1,1'-biphenyl]-4-yl)methyl]-beta-alanyl}amino)propyl]amino}-1H-indazole-6-carboxylic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I84
 | | Crystal Structure of APL1867 bound to CK2a | | Descriptor: | 5-({2-[(4-{[(2-chloro[1,1'-biphenyl]-4-yl)methyl]amino}butyl)amino]ethyl}amino)-N-(methanesulfonyl)benzo[c][2,6]naphthyridine-8-carboxamide, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I88
 | | Crystal Structure of 50 bound to CK2a | | Descriptor: | 5-[(2-formamidoethyl)amino]benzo[c][2,6]naphthyridine-8-carboxamide, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I8N
 | | Crystal Structure of 12 bound to CK2a | | Descriptor: | (4P)-3-{[3-({N-[(2-chloro[1,1'-biphenyl]-4-yl)methyl]-beta-alanyl}amino)propyl]amino}-4-(1H-pyrazol-5-yl)benzoic acid, ACETATE ION, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
To be published
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7I81
 | | Crystal Structure of 22 bound to CK2a | | Descriptor: | 5-{[3-({N-[(2-chloro[1,1'-biphenyl]-4-yl)methyl]-beta-alanyl}amino)propyl]amino}benzo[c][2,6]naphthyridine-8-carboxylic acid, Casein kinase II subunit alpha | | Authors: | Brear, P, Glossop, P, Pandey, S, Hyvonen, M, Spring, D, Butt, R, Cawkill, D. | | Deposit date: | 2025-03-12 | | Release date: | 2026-01-14 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Anti-tumor Efficacy of CK2α inhibition in Wnt-Driven Colorectal Cancer
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