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4YVG
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BU of 4yvg by Molmil
Crystal Structure of H. influenzae TrmD in complex with AdoMet
Descriptor: S-ADENOSYLMETHIONINE, tRNA (guanine-N(1)-)-methyltransferase
Authors:Ito, T, Yokoyama, S.
Deposit date:2015-03-20
Release date:2015-07-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.549 Å)
Cite:Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YVJ
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BU of 4yvj by Molmil
Crystal Structure of H. influenzae TrmD in complex with sinefungin and tRNA variant (G36U)
Descriptor: SINEFUNGIN, tRNA, tRNA (guanine-N(1)-)-methyltransferase
Authors:Yoshida, K, Ito, T, Yokoyama, S.
Deposit date:2015-03-20
Release date:2015-07-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.
Proc.Natl.Acad.Sci.USA, 112, 2015
8H0W
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BU of 8h0w by Molmil
RNA polymerase II transcribing a chromatosome (type II)
Descriptor: DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ...
Authors:Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H.
Deposit date:2022-09-30
Release date:2022-12-07
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.
Nat Commun, 13, 2022
8H0V
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BU of 8h0v by Molmil
RNA polymerase II transcribing a chromatosome (type I)
Descriptor: DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ...
Authors:Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H.
Deposit date:2022-09-30
Release date:2022-12-07
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1.
Nat Commun, 13, 2022
8GZR
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BU of 8gzr by Molmil
Cryo-EM structure of the the NS5-NS3 RNA-elongation complex
Descriptor: CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ...
Authors:Osawa, T, Ehara, H, Sekine, S.
Deposit date:2022-09-27
Release date:2023-08-02
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structures of dengue virus RNA replicase complexes.
Mol.Cell, 83, 2023
8GZQ
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BU of 8gzq by Molmil
Cryo-EM structure of the NS5-NS3-SLA complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, RNA, ...
Authors:Osawa, T, Ehara, H, Sekine, S.
Deposit date:2022-09-27
Release date:2023-08-02
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of dengue virus RNA replicase complexes.
Mol.Cell, 83, 2023
8GZP
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BU of 8gzp by Molmil
Cryo-EM structure of the NS5-SLA complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ...
Authors:Osawa, T, Ehara, H, Sekine, S.
Deposit date:2022-09-27
Release date:2023-08-02
Last modified:2023-08-23
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of dengue virus RNA replicase complexes.
Mol.Cell, 83, 2023
8HSH
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BU of 8hsh by Molmil
Thermus thermophilus RNA polymerase coreenzyme
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Murayama, Y, Ehara, H, Sekine, S.
Deposit date:2022-12-19
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
8HSG
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BU of 8hsg by Molmil
Thermus thermophilus RNA polymerase elongation complex
Descriptor: DNA (27-MER), DNA (37-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Murayama, Y, Ehara, H, Sekine, S.
Deposit date:2022-12-19
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
8HSL
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BU of 8hsl by Molmil
Thermus thermophilus RNA polymerase bound with an inverted Rho hexamer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ...
Authors:Murayama, Y, Ehara, H, Sekine, S.
Deposit date:2022-12-19
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
8HSJ
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BU of 8hsj by Molmil
Thermus thermophilus transcription termination factor Rho bound with ADP-BeF3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ...
Authors:Murayama, Y, Ehara, H, Sekine, S.
Deposit date:2022-12-19
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
8HSR
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BU of 8hsr by Molmil
Thermus thermophilus Rho-engaged RNAP elongation complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ...
Authors:Murayama, Y, Ehara, H, Sekine, S.
Deposit date:2022-12-20
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
2ZOD
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BU of 2zod by Molmil
Crystal structure of selenophosphate synthetase from Aquifex aeolicus
Descriptor: SULFATE ION, Selenide, water dikinase
Authors:Sekine, S.I, Matsumoto, E, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2008-05-09
Release date:2008-05-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure of selenophosphate synthetase essential for selenium incorporation into proteins and RNAs.
J.Mol.Biol., 385, 2009
7XSE
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BU of 7xse by Molmil
RNA polymerase II elongation complex transcribing a nucleosome (EC42)
Descriptor: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ...
Authors:Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2022-05-13
Release date:2022-09-07
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science, 377, 2022
7XSX
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BU of 7xsx by Molmil
RNA polymerase II elongation complex transcribing a nucleosome (EC49)
Descriptor: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ...
Authors:Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2022-05-15
Release date:2022-09-07
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science, 377, 2022
7XN7
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BU of 7xn7 by Molmil
RNA polymerase II elongation complex containing Spt4/5, Elf1, Spt6, Spn1 and Paf1C
Descriptor: Chromatin elongation factor SPT5, Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, ...
Authors:Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2022-04-28
Release date:2022-09-07
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science, 377, 2022
7XTD
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BU of 7xtd by Molmil
RNA polymerase II elongation complex transcribing a nucleosome (EC58oct)
Descriptor: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ...
Authors:Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2022-05-16
Release date:2022-09-07
Last modified:2022-10-19
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science, 377, 2022
7XSZ
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BU of 7xsz by Molmil
RNA polymerase II elongation complex transcribing a nucleosome (EC115)
Descriptor: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ...
Authors:Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2022-05-15
Release date:2022-09-07
Last modified:2022-10-12
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science, 377, 2022
7XTI
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BU of 7xti by Molmil
RNA polymerase II elongation complex transcribing a nucleosome (EC58hex)
Descriptor: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ...
Authors:Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2022-05-17
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science, 377, 2022
7XT7
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BU of 7xt7 by Molmil
RNA polymerase II elongation complex transcribing a nucleosome (EC49B)
Descriptor: Component of the Paf1p complex, Constituent of Paf1 complex with RNA polymerase II, Paf1p, ...
Authors:Ehara, H, Kujirai, T, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2022-05-16
Release date:2022-10-12
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of nucleosome disassembly and reassembly by RNAPII elongation complex with FACT.
Science, 377, 2022
6IR9
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BU of 6ir9 by Molmil
RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-1) of the nucleosome
Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ...
Authors:Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2018-11-12
Release date:2019-02-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
6J50
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BU of 6j50 by Molmil
RNA polymerase II elongation complex bound with Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome (tilted conformation)
Descriptor: DNA (198-MER), DNA (41-MER), DNA-directed RNA polymerase subunit, ...
Authors:Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
6IZZ
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BU of 6izz by Molmil
The RNA-dependent RNA polymerase domain of dengue 3 NS5, bound with RK-0404678
Descriptor: 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, Genome polyprotein, ZINC ION
Authors:Shimizu, H, Sekine, S.
Deposit date:2018-12-20
Release date:2019-12-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.
Plos Negl Trop Dis, 13, 2019
6J4W
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BU of 6j4w by Molmil
RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-5) of the nucleosome
Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ...
Authors:Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
6J00
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BU of 6j00 by Molmil
The RNA-dependent RNA polymerase domain of dengue 3 NS5
Descriptor: Genome polyprotein, ZINC ION
Authors:Shimizu, H, Sekine, S.
Deposit date:2018-12-20
Release date:2019-12-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase.
Plos Negl Trop Dis, 13, 2019

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