8S6E
 
 | | Monoclonal antibody MenW targeting serogroup W of Neisseria meningitidis | | Descriptor: | MenW.01 Heavy chain, MenW.01 Light chain, SODIUM ION | | Authors: | Pietri, G.P, Bertuzzi, S, Karnicar, K, Unione, L, Lisnic, B, Malic, S, Miklic, K, Novak, M, Calloni, I, Santini, L, Usenik, A, Rosaria Romano, M, Adamo, R, Jonjic, S, Turk, D, Jimenez-Barbero, J, Lenac Rovis, T. | | Deposit date: | 2024-02-27 | | Release date: | 2024-06-26 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Antigenic determinants driving serogroup-specific antibody response to Neisseria meningitidis C, W, and Y capsular polysaccharides: Insights for rational vaccine design.
Carbohydr Polym, 341, 2024
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7OO2
 | | Crystal structure of an antibody targeting the capsular polysaccharide of serogroup X Neisseria meningitidis (MenX) | | Descriptor: | THIOCYANATE ION, anti-MenX Fab heavy chain, anti-MenX Fab light chain | | Authors: | Pietri, G.P, de Ruyck, J, Lenac, T, Adamo, R, Bouckaert, J. | | Deposit date: | 2021-05-26 | | Release date: | 2021-10-06 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Elucidating the Structural and Minimal Protective Epitope of the Serogroup X Meningococcal Capsular Polysaccharide.
Front Mol Biosci, 8, 2021
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6H2Y
 | | human Fab 1E6 bound to fHbp variant 3 from Neisseria meningitidis serogroup B | | Descriptor: | 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Veggi, D, Bianchi, F, Cozzi, R, Malito, E, Bottomley, M.J. | | Deposit date: | 2018-07-17 | | Release date: | 2019-08-14 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6.
Faseb J., 33, 2019
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5UR8
 | | Human antibody fragment (Fab) to meningococcal Factor H binding protein | | Descriptor: | human immunoglobulin gamma, heavy chain Fd fragment, kappa light chain | | Authors: | Beernink, P.T. | | Deposit date: | 2017-02-09 | | Release date: | 2018-02-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.75500226 Å) | | Cite: | Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.
Nat Commun, 9, 2018
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5O14
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4CJD
 | | Crystal structure of Neisseria meningitidis trimeric autotransporter and vaccine antigen NadA | | Descriptor: | IODIDE ION, NADA | | Authors: | Malito, E, Biancucci, M, Spraggon, G, Bottomley, M.J. | | Deposit date: | 2013-12-19 | | Release date: | 2014-11-26 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.056 Å) | | Cite: | Structure of the Meningococcal Vaccine Antigen Nada and Epitope Mapping of a Bactericidal Antibody.
Proc.Natl.Acad.Sci.USA, 111, 2014
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5T5F
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2YPV
 | | Crystal structure of the Meningococcal vaccine antigen factor H binding protein in complex with a bactericidal antibody | | Descriptor: | 1,2-ETHANEDIOL, FAB 12C1, LIPOPROTEIN | | Authors: | Malito, E, Veggi, D, Bottomley, M.J. | | Deposit date: | 2012-11-01 | | Release date: | 2013-02-20 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Defining a Protective Epitope on Factor H Binding Protein, a Key Meningococcal Virulence Factor and Vaccine Antigen.
Proc.Natl.Acad.Sci.USA, 110, 2013
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8BK2
 | | X-ray structure of meningococcal factor H binding protein variant 2 in complex with a specific and bactericidal human monoclonal antibody 1B1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... | | Authors: | Veggi, D, Bottomley, J.M. | | Deposit date: | 2022-11-08 | | Release date: | 2023-11-22 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H.
Faseb Bioadv, 6, 2024
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6XZW
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