7PK1
 
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2CEO
 | | thyroxine-binding globulin complex with thyroxine | | 分子名称: | 3,5,3',5'-TETRAIODO-L-THYRONINE, GLYCEROL, THYROXINE-BINDING GLOBULIN | | 著者 | Zhou, A, Wei, Z, Read, R.J, Carrell, R.W. | | 登録日 | 2006-02-08 | | 公開日 | 2006-08-14 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Mechanism for the Carriage and Release of Thyroxine in the Blood.
Proc.Natl.Acad.Sci.USA, 103, 2006
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2CLW
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6EOE
 | | Crystal structure of AMPylated GRP78 with nucleotide | | 分子名称: | 78 kDa glucose-regulated protein, ADENOSINE-5'-DIPHOSPHATE, CITRATE ANION, ... | | 著者 | Yan, Y, Preissler, S, Ron, D, Read, R.J. | | 登録日 | 2017-10-09 | | 公開日 | 2017-11-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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6EOB
 | | Crystal structure of AMPylated GRP78 in apo form (Crystal form 1) | | 分子名称: | 78 kDa glucose-regulated protein, PHOSPHATE ION | | 著者 | Yan, Y, Preissler, S, Ron, D, Read, R.J. | | 登録日 | 2017-10-09 | | 公開日 | 2017-11-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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6EOC
 | | Crystal structure of AMPylated GRP78 in apo form (Crystal form 2) | | 分子名称: | 78 kDa glucose-regulated protein, CITRATE ANION, SULFATE ION | | 著者 | Yan, Y, Preissler, S, Ron, D, Read, R.J. | | 登録日 | 2017-10-09 | | 公開日 | 2017-11-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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6EOF
 | | Crystal structure of AMPylated GRP78 in ADP state | | 分子名称: | 78 kDa glucose-regulated protein, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Yan, Y, Preissler, S, Read, R.J, Ron, D. | | 登録日 | 2017-10-09 | | 公開日 | 2017-11-01 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.
Elife, 6, 2017
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8AXG
 | | Crystal structure of Fusobacterium nucleatum fusolisin protease | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Fusolisin, ... | | 著者 | Isupov, M.N, Wiener, R, Rouvinski, A, Fahoum, J, Kumar, M, Read, R.J. | | 登録日 | 2022-08-31 | | 公開日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Crystal structure of Fusobacterium nucleatum fusolisin protease
To Be Published
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6RPX
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6RPZ
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6RPY
 | | Cytokine receptor-like factor 3 C-terminus residues 174-442: Hg-SAD derivative | | 分子名称: | Cytokine receptor-like factor 3, MERCURY (II) ION | | 著者 | Mifsud, R.W, Yan, Y, Bennett, C, Read, R.J. | | 登録日 | 2019-05-15 | | 公開日 | 2020-03-25 | | 最終更新日 | 2022-10-05 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia.
Blood, 139, 2022
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3ZR5
 | | STRUCTURE OF GALACTOCEREBROSIDASE FROM MOUSE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Deane, J.E, Graham, S.C, Kim, N.N, Stein, P.E, Mcnair, R, Cachon-Gonzalez, M.B, Cox, T.M, Read, R.J. | | 登録日 | 2011-06-14 | | 公開日 | 2011-09-28 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Insights Into Krabbe Disease from Structures of Galactocerebrosidase.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3ZR6
 | | STRUCTURE OF GALACTOCEREBROSIDASE FROM MOUSE IN COMPLEX WITH GALACTOSE | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Deane, J.E, Graham, S.C, Kim, N.N, Stein, P.E, Mcnair, R, Cachon-Gonzalez, M.B, Cox, T.M, Read, R.J. | | 登録日 | 2011-06-14 | | 公開日 | 2011-09-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Insights Into Krabbe Disease from Structures of Galactocerebrosidase.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4A5M
 | | Redox regulator HypR in its oxidized form | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR YYBR | | 著者 | Palm, G.J, Waack, P, Read, R.J, Hinrichs, W. | | 登録日 | 2011-10-26 | | 公開日 | 2012-01-11 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Insights Into the Redox-Switch Mechanism of the Marr/Duf24-Type Regulator Hypr
Nucleic Acids Res., 40, 2012
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4A5N
 | | Redoxregulator HypR in its reduced form | | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR YYBR | | 著者 | Palm, G.J, Waack, P, Read, R.J, Hinrichs, W. | | 登録日 | 2011-10-26 | | 公開日 | 2012-01-11 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Structural Insights Into the Redox-Switch Mechanism of the Marr/Duf24-Type Regulator Hypr
Nucleic Acids Res., 40, 2012
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4AUT
 | | Crystal structure of the tuberculosis drug target Decaprenyl- Phosphoryl-beta-D-Ribofuranose-2-oxidoreductase (DprE1) from Mycobacterium smegmatis | | 分子名称: | DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Neres, J, Pojer, F, Molteni, E, Chiarelli, L.R, Dhar, N, Boy-Rottger, S, Buroni, S, Fullam, E, Degiacomi, G, Lucarelli, A, Read, R.J, Zanoni, G, Edmondson, D.E, De Rossi, E, Pasca, M, Riccardi, G, Mattevi, A, Dyson, P.J, Cole, S.T, Binda, C. | | 登録日 | 2012-05-21 | | 公開日 | 2012-09-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis.
Sci. Transl. Med., 4, 2012
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4CCC
 | | STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH 4NBDG: ENZYME-SUBSTRATE COMPLEX | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-nitrophenyl beta-D-galactopyranoside, ... | | 著者 | Hill, C.H, Graham, S.C, Read, R.J, Deane, J.E. | | 登録日 | 2013-10-21 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
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4CCE
 | | STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH GALACTOSE: ENZYME- PRODUCT COMPLEX | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Hill, C.H, Graham, S.C, Read, R.J, Deane, J.E. | | 登録日 | 2013-10-21 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
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4C49
 | | Reactive loop cleaved human CBG in complex with cortisol | | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, CORTICOSTEROID-BINDING GLOBULIN | | 著者 | Chan, W.L, Zhou, A, Read, R.J. | | 登録日 | 2013-09-02 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Role of Sa-Hd Loop Movement in Cortisol Release Mechanism of Cbg
To be Published
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4C41
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4CCD
 | | STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH D-GALACTAL: ENZYME- INTERMEDIATE COMPLEX | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-alpha-D-galactopyranose, ... | | 著者 | Hill, C.H, Graham, S.C, Read, R.J, Deane, J.E. | | 登録日 | 2013-10-21 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
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4UFI
 | | Mouse Galactocerebrosidase complexed with aza-galacto-fagomine AGF | | 分子名称: | (3R,4S,5R)-3-(hydroxymethyl)-1,2-diazinane-4,5-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E. | | 登録日 | 2015-03-17 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
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4UFK
 | | Mouse Galactocerebrosidase complexed with dideoxy-imino-lyxitol DIL | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E. | | 登録日 | 2015-03-17 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.402 Å) | | 主引用文献 | Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
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4UFH
 | | Mouse Galactocerebrosidase complexed with iso-galacto-fagomine IGF | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E. | | 登録日 | 2015-03-17 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
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4UFJ
 | | Mouse Galactocerebrosidase complexed with iso-galacto-fagomine lactam IGL | | 分子名称: | (3S,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E. | | 登録日 | 2015-03-17 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
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