7FGQ
 
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7VEP
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6KDU
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | Descriptor: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | | Authors: | Ramachandran, R, Shukla, A, Afsar, M. | | Deposit date: | 2019-07-02 | | Release date: | 2020-07-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
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8K4E
 | | Cryo-EM structure of 30S ribosome with cleaved AP-mRNA bound complex-II | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Ramachandran, R, Afsar, M, Shukla, A. | | Deposit date: | 2023-07-18 | | Release date: | 2024-07-24 | | Last modified: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Bacterial Rps3 counters oxidative and UV stress by recognizing and processing AP-sites on mRNA via a novel mechanism.
Nucleic Acids Res., 52, 2024
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6KJM
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | Descriptor: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | | Authors: | Ramachandran, R, Shukla, A, Afsar, M. | | Deposit date: | 2019-07-22 | | Release date: | 2020-07-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
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6KKV
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6KSD
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6KRH
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | Descriptor: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | | Authors: | Ramachandran, R, Shukla, A, Afsar, M. | | Deposit date: | 2019-08-21 | | Release date: | 2020-08-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
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6KSC
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6LW8
 | | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | | Descriptor: | (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, DNA ligase A, GLYCEROL, ... | | Authors: | Ramachandran, R, Afsar, M, Shukla, A. | | Deposit date: | 2020-02-07 | | Release date: | 2021-02-10 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A.
J.Struct.Biol., 213, 2021
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8K3O
 | | Cryo-EM structure of 30S ribosome with cleaved AP-mRNA bound complex I | | Descriptor: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Afsar, M, Shukla, A, Ramachandran, R. | | Deposit date: | 2023-07-16 | | Release date: | 2024-07-24 | | Last modified: | 2025-01-08 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Bacterial Rps3 counters oxidative and UV stress by recognizing and processing AP-sites on mRNA via a novel mechanism.
Nucleic Acids Res., 52, 2024
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5T41
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4PCQ
 | | Crystal Structure of MtbAldR (Rv2779c) | | Descriptor: | Possible transcriptional regulatory protein (Probably Lrp/AsnC-family) | | Authors: | Dey, A, Ramachandran, R. | | Deposit date: | 2014-04-16 | | Release date: | 2015-05-06 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Crystal structure of MtbAldR
To be published
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1Z30
 | | NMR structure of the apical part of stemloop D from cloverleaf 1 of bovine enterovirus 1 RNA | | Descriptor: | 5'-R(*GP*GP*CP*GP*UP*UP*CP*GP*UP*UP*AP*GP*AP*AP*CP*GP*UP*C)-3' | | Authors: | Ihle, Y, Ohlenschlager, O, Duchardt, E, Ramachandran, R, Gorlach, M. | | Deposit date: | 2005-03-10 | | Release date: | 2005-04-26 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA
Nucleic Acids Res., 33, 2005
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1UUU
 | | STRUCTURE OF AN RNA HAIRPIN LOOP WITH A 5'-CGUUUCG-3' LOOP MOTIF BY HETERONUCLEAR NMR SPECTROSCOPY AND DISTANCE GEOMETRY, 15 STRUCTURES | | Descriptor: | RNA (5'-R(*GP*GP*CP*GP*UP*AP*CP*GP*UP*UP*UP*CP*GP*UP*AP*CP*GP*CP*C)-3') | | Authors: | Sich, C, Ohlenschlager, O, Ramachandran, R, Gorlach, M, Brown, L.R. | | Deposit date: | 1997-08-12 | | Release date: | 1998-02-25 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of an RNA hairpin loop with a 5'-CGUUUCG-3' loop motif by heteronuclear NMR spectroscopy and distance geometry.
Biochemistry, 36, 1997
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1SSN
 | | STAPHYLOKINASE, SAKSTAR VARIANT, NMR, 20 STRUCTURES | | Descriptor: | STAPHYLOKINASE | | Authors: | Ohlenschlager, O, Ramachandran, R, Guhrs, K.H, Schlott, B, Brown, L.R. | | Deposit date: | 1998-06-07 | | Release date: | 1998-12-02 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance solution structure of the plasminogen-activator protein staphylokinase.
Biochemistry, 37, 1998
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3RB9
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3S5C
 | | Crystal Structure of a Hexachlorocyclohexane dehydrochlorinase (LinA) Type2 | | Descriptor: | LinA | | Authors: | Kukshal, V, Macwan, A.S, Kumar, A, Ramachandran, R. | | Deposit date: | 2011-05-23 | | Release date: | 2012-05-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structure of the hexachlorocyclohexane dehydrochlorinase (LinA-type2): mutational analysis, thermostability and enantioselectivity
Plos One, 7, 2012
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1M4Y
 | | Crystal structure of HslV from Thermotoga maritima | | Descriptor: | ATP-dependent protease hslV, SODIUM ION | | Authors: | Song, H.K, Ramachandran, R, Bochtler, M.B, Hartmann, C, Azim, M.K, Huber, R. | | Deposit date: | 2002-07-05 | | Release date: | 2003-05-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV.
BIOPHYS.CHEM., 100, 2003
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5IS2
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5IT4
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5IT0
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5JLR
 | | Crystal structure of Mycobacterium avium SerB2 with serine present at slightly different position near ACT domain | | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, MAGNESIUM ION, ... | | Authors: | Shree, S, Agrawal, A, Dubey, S, Ramachandran, R. | | Deposit date: | 2016-04-27 | | Release date: | 2017-05-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.261 Å) | | Cite: | Crystal structure of Mycobacterium avium SerB2 with serine present at slightly different position near ACT domain
To be published
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5JMA
 | | Crystal structure of Mycobacterium avium SerB2 in complex with serine at catalytic (PSP) domain | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Phosphoserine phosphatase, ... | | Authors: | Shree, S, Dubey, S, Agrawal, A, Ramachandran, R. | | Deposit date: | 2016-04-28 | | Release date: | 2017-05-03 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Crystal structure of Mycobacterium avium SerB2 in complex with serine at catalytic (PSP) domain
To be published
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5JLP
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