2Y0R
 
 | | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | | 分子名称: | MYOSIN-2 HEAVY CHAIN | | 著者 | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | | 登録日 | 2010-12-07 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
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2XO8
 | | Crystal Structure of Myosin-2 in Complex with Tribromodichloropseudilin | | 分子名称: | 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | | 著者 | Preller, M, Chinthalapudi, K, Martin, R, Knoelker, H.J, Manstein, D.J. | | 登録日 | 2010-08-10 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study.
J.Med.Chem., 54, 2011
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2Y9E
 | | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | | 分子名称: | MYOSIN-2 | | 著者 | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | | 登録日 | 2011-02-14 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.397 Å) | | 主引用文献 | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
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2Y8I
 | | Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN | | 著者 | Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. | | 登録日 | 2011-02-07 | | 公開日 | 2011-07-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.132 Å) | | 主引用文献 | Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V.
J.Biol.Chem., 286, 2011
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8OOM
 | | Structural and functional studies of geldanamycin amide synthase ShGdmF | | 分子名称: | (2R)-2,4-dihydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide, ACETATE ION, GdmF | | 著者 | Ewert, W, Zeilinger, C, Kirschning, A, Preller, M. | | 登録日 | 2023-04-05 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Structural and functional studies of geldanamycin amide synthase ShGdmF
To Be Published
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6Q6F
 | | Crystal structure of IDH1 R132H in complex with HMS101 | | 分子名称: | (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine, Isocitrate dehydrogenase [NADP] cytoplasmic | | 著者 | Chaturvedi, A, Goparaju, R, Gupta, C, Kluenemann, T, Araujo Cruz, M.M, Kloos, A, Goerlich, K, Schottmann, R, Struys, E.A, Ganser, A, Preller, M, Heuser, M. | | 登録日 | 2018-12-10 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Leukemia, 34, 2020
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5I4E
 | | Crystal Structure of Human Nonmuscle Myosin 2C motor domain | | 分子名称: | ADP ORTHOVANADATE, MAGNESIUM ION, Myosin-14,Alpha-actinin A | | 著者 | Chinthalapudi, K, Heissler, S.M, Preller, M, Sellers, J.R, Manstein, D.J. | | 登録日 | 2016-02-11 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
Elife, 6, 2017
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7B1A
 | | Myosin-II-AA mutant motor domain | | 分子名称: | 1,2-ETHANEDIOL, ADP METAVANADATE, MAGNESIUM ION, ... | | 著者 | Ewert, W, Preller, M. | | 登録日 | 2020-11-24 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
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7B19
 | | Mutant Myosin-II-GGG motor domain | | 分子名称: | ADP METAVANADATE, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Ewert, W, Preller, M. | | 登録日 | 2020-11-24 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and P i Release.
Int J Mol Sci, 22, 2020
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6Z7U
 | | Myosin-II motor domain complexed with blebbistatin in a new ADP-release conformation | | 分子名称: | (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Ewert, W, Preller, M. | | 登録日 | 2020-06-01 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Int J Mol Sci, 21, 2020
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6Z7T
 | | Nucleotide-free Myosin-II motor domain | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Ewert, W, Preller, M. | | 登録日 | 2020-06-01 | | 公開日 | 2020-10-21 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Int J Mol Sci, 21, 2020
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6Z2S
 | | Crystal structure of adhibin analogue-bound myosin-2 | | 分子名称: | 3,6-dibromo-1-(hydroxymethyl)carbazole, ACETATE ION, ADP METAVANADATE, ... | | 著者 | Ewert, W, Knoelker, H.-J, Tsiavaliaris, G, Preller, M. | | 登録日 | 2020-05-18 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The synthetic carbazole adhibin acts as selective myosin class-IX inhibitor in lung cancer cells
To Be Published
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2XEL
 | | Molecular Mechanism of Pentachloropseudilin Mediated Inhibition of Myosin Motor Activity | | 分子名称: | 2,4-DICHLORO-6-(3,4,5-TRICHLORO-1H-PYRROL-2YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... | | 著者 | Chinthalapudi, K, Taft, M.H, Martin, R, Hartmann, F.K, Heissler, S.M, Tsiavaliaris, G, Gutzeit, H.O, Knoelker, H.J, Coluccio, L.M, Fedorov, R, Manstein, D.J. | | 登録日 | 2010-05-16 | | 公開日 | 2011-06-15 | | 最終更新日 | 2011-08-31 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mechanism and Specificity of Pentachloropseudilin-Mediated Inhibition of Myosin Motor Activity.
J.Biol.Chem., 286, 2011
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