3N5E
 
 | | Crystal Structure of human thymidylate synthase bound to a peptide inhibitor | | 分子名称: | SULFATE ION, Synthetic peptide LR, Thymidylate synthase | | 著者 | Pozzi, C, Cardinale, D, Guaitoli, G, Tondi, D, Luciani, R, Myllykallio, H, Ferrari, S, Costi, M.P, Mangani, S. | | 登録日 | 2010-05-25 | | 公開日 | 2011-06-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3N5G
 | | Crystal Structure of histidine-tagged human thymidylate synthase | | 分子名称: | SULFATE ION, Thymidylate synthase | | 著者 | Pozzi, C, Cardinale, D, Guaitoli, G, Tondi, D, Luciani, R, Myllykallio, H, Ferrari, S, Costi, M.P, Mangani, S. | | 登録日 | 2010-05-25 | | 公開日 | 2011-06-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Proc.Natl.Acad.Sci.USA, 108, 2011
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6GDO
 | | Trypanosoma brucei PTR1 in complex with inhibitor 2g (F240) | | 分子名称: | ACETATE ION, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Pozzi, C, Landi, G, Mangani, S. | | 登録日 | 2018-04-24 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.
J.Med.Chem., 62, 2019
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5NJW
 | | Crystal Structure of BJP-1 metallo beta-lactamase in complex with boric acid | | 分子名称: | 1,2-ETHANEDIOL, BORIC ACID, Blr6230 protein, ... | | 著者 | Pozzi, C, Di Pisa, F, Benvenuti, M, Mangani, S. | | 登録日 | 2017-03-29 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Boric acid and acetate anion binding to subclass B3 metallo-Beta-lactamase BJP-1 provides clues for mechanism of action and inhibitor design
Inorg.Chim.Acta., 2017
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5NGG
 | | Crystal structure of the subclass B3 metallo-beta-lactamase BJP-1 in complex with acetate anion | | 分子名称: | ACETATE ION, Blr6230 protein, ZINC ION | | 著者 | Pozzi, C, Di Pisa, F, Benvenuti, M, Mangani, S. | | 登録日 | 2017-03-17 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Boric acid and acetate anion binding to subclass B3 metallo-Beta-lactamase BJP-1 provides clues for mechanism of action and inhibitor design
Inorg.Chim.Acta., 2017
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4P18
 | | Crystal Structure of frog M ferritin mutant D80K | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | 著者 | Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Ghini, V, Turano, P. | | 登録日 | 2014-02-25 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Loop electrostatics modulates the intersubunit interactions in ferritin.
Acs Chem.Biol., 9, 2014
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5J93
 | | Five minutes iron loaded Rana Catesbeiana H' ferritin variant E57A/E136A/D140A | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Turano, P. | | 登録日 | 2016-04-08 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.
Chemistry, 22, 2016
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5J8W
 | | One minute iron loaded Rana Catesbeiana H' ferritin variant E57A/E136A/D140A | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Turano, P. | | 登録日 | 2016-04-08 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.11 Å) | | 主引用文献 | Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.
Chemistry, 22, 2016
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5J8S
 | | Iron-free state of Rana Catesbeiana H' ferritin variant E57A/E136A/D140A | | 分子名称: | CHLORIDE ION, Ferritin, middle subunit, ... | | 著者 | Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Turano, P. | | 登録日 | 2016-04-08 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.
Chemistry, 22, 2016
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5J9V
 | | Ten minutes iron loaded Rana Catesbeiana H' ferritin variant E57A/E136A/D140A | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Turano, P. | | 登録日 | 2016-04-11 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.
Chemistry, 22, 2016
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3IK1
 | | Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-hydroxy-4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzoic acid, Thymidylate synthase | | 著者 | Pozzi, C, Cancian, L, Leone, R, Luciani, R, Ferrari, S, Mangani, S, Costi, M.P. | | 登録日 | 2009-08-05 | | 公開日 | 2010-08-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening
J.Med.Chem., 54, 2011
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3IJZ
 | | Lactobacillus casei Thymidylate Synthase ternary complex with dUMP and Pthalimidic derivative 15C | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(4-acetylphenyl)-4-methyl-1H-isoindole-1,3(2H)-dione, Thymidylate synthase | | 著者 | Pozzi, C, Cancian, L, Leone, R, Luciani, R, Ferrari, S, Mangani, S, Costi, M.P. | | 登録日 | 2009-08-05 | | 公開日 | 2010-08-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening
J.Med.Chem., 54, 2011
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3IK0
 | | Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 7C1 | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzenecarboximidamide, Thymidylate synthase | | 著者 | Pozzi, C, Cancian, L, Leone, R, Luciani, R, Ferrari, S, Mangani, S, Costi, M.P. | | 登録日 | 2009-08-05 | | 公開日 | 2010-08-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening
J.Med.Chem., 54, 2011
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5JAC
 | | Sixty minutes iron loaded Rana Catesbeiana H' ferritin variant E57A/E136A/D140A | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Pozzi, C, Di Pisa, F, Mangani, S, Bernacchioni, C, Turano, P. | | 登録日 | 2016-04-12 | | 公開日 | 2016-10-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.
Chemistry, 22, 2016
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5IZC
 | | Trypanosoma brucei PTR1 in complex with inhibitor F032 | | 分子名称: | ACETATE ION, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Pozzi, C, Landi, G, Di Pisa, F, Mangani, S. | | 登録日 | 2016-03-25 | | 公開日 | 2017-04-05 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.
ACS Omega, 2, 2017
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4LQH
 | | High resolution structure of native frog M ferritin | | 分子名称: | CHLORIDE ION, Ferritin, middle subunit, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-07-18 | | 公開日 | 2014-07-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4LQV
 | | Thrirty minutes iron loaded frog M ferritin | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-07-19 | | 公開日 | 2014-07-23 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4LYU
 | | Fifteen minutes iron loaded frog M ferritin | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-07-31 | | 公開日 | 2014-08-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4LYX
 | | five minutes iron loaded frog M ferritin | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-07-31 | | 公開日 | 2014-08-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4LPJ
 | | One minute iron loaded frog M ferritin | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-07-16 | | 公開日 | 2014-08-06 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4LQJ
 | | Two minutes iron loaded frog M ferritin | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-07-18 | | 公開日 | 2014-09-17 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4MKU
 | | Frog M ferritin mutant H54Q | | 分子名称: | CHLORIDE ION, Ferritin, middle subunit, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-09-05 | | 公開日 | 2014-09-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4MN9
 | | Fifteen minutes iron loaded frog M ferritin mutant H54Q | | 分子名称: | CHLORIDE ION, FE (III) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-09-10 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4ML5
 | | one minute iron loaded frog M ferritin mutant H54Q | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-09-06 | | 公開日 | 2014-09-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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4MJY
 | | Sixty minutes iron loaded frog M ferritin mutant H54Q | | 分子名称: | CHLORIDE ION, FE (II) ION, Ferritin, ... | | 著者 | Mangani, S, Di Pisa, F, Pozzi, C, Turano, P, Lalli, D. | | 登録日 | 2013-09-04 | | 公開日 | 2014-09-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
Acta Crystallogr.,Sect.D, 71, 2015
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