6FPA
| Crystal structure of anti-mTFP1 DARPin 1238_G01 in space group P212121 | Descriptor: | DARPin 1238_G01 | Authors: | Jakob, R.P, Vigano, M.A, Bieli, D, Matsuda, S, Schaefer, J.V, Pluckthun, A, Affolter, M, Maier, T. | Deposit date: | 2018-02-09 | Release date: | 2018-10-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | DARPins recognizing mTFP1 as novel reagents forin vitroandin vivoprotein manipulations. Biol Open, 7, 2018
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7P02
| Human Neurokinin 1 receptor (NK1R) substance P Gs complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | Deposit date: | 2021-06-29 | Release date: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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7P00
| Human Neurokinin 1 receptor (NK1R) substance P Gq chimera (mGsqi) complex | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Thom, C, Ehrenmann, J, Vacca, S, Waltenspuhl, Y, Schoppe, J, Medalia, O, Pluckthun, A. | Deposit date: | 2021-06-29 | Release date: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Structures of neurokinin 1 receptor in complex with G q and G s proteins reveal substance P binding mode and unique activation features. Sci Adv, 7, 2021
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4DB6
| Designed Armadillo repeat protein (YIIIM3AII) | Descriptor: | Armadillo repeat protein | Authors: | Madhurantakam, C, Varadamsetty, G, Grutter, M.G, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2012-01-13 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci., 21, 2012
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4DB8
| Designed Armadillo-repeat Protein | Descriptor: | Armadillo-repeat Protein, MAGNESIUM ION | Authors: | Madhurantakam, C, Varadamsetty, G, Grutter, M.G, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2012-01-13 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci., 21, 2012
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4DBA
| Designed Armadillo repeat protein (YIIM3AII) | Descriptor: | Designed Armadillo repeat protein, YIIM3AII, GLYCEROL | Authors: | Madhurantakam, C, Varadamsetty, G, Grutter, M.G, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2012-01-13 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci., 21, 2012
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4DB9
| Designed Armadillo repeat protein (YIIIM3AIII) | Descriptor: | Armadillo repeat protein, YIIIM3AIII | Authors: | Madhurantakam, C, Varadamsetty, G, Grutter, M.G, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2012-01-13 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci., 21, 2012
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4DUI
| DARPIN D1 binding to tubulin beta chain (not in complex) | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, DESIGNED ANKYRIN REPEAT PROTEIN (DARPIN) D1 | Authors: | Pecqueur, L, Duellberg, C, Dreier, B, Wang, Q, Jiang, C, Pluckthun, A, Surrey, T, Gigant, B, Knossow, M. | Deposit date: | 2012-02-22 | Release date: | 2013-02-27 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | An Anti-Tubulin Darpin Caps the Microtubule Plus-End To be Published
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6QEV
| EngBF DARPin Fusion 4b B6 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (II) ION, PEGA domain-containing protein,PEGA domain-containing protein,EngBF DARPin fusion B6 complex, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-08 | Release date: | 2019-11-06 | Last modified: | 2020-04-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6QFK
| EngBF DARPin Fusion 4b G10 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-10 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6QEP
| EngBF DARPin Fusion 4b H14 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-08 | Release date: | 2019-11-06 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6QFO
| EngBF DARPin Fusion 9b 3G124 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-01-10 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6R5W
| Crystal structure of the receptor binding protein (gp15) of Listeria phage PSA | Descriptor: | ACETATE ION, CADMIUM ION, Gp15 protein, ... | Authors: | Dunne, M, Ernst, P, Pluckthun, A, Loessner, M.J, Kilcher, S. | Deposit date: | 2019-03-25 | Release date: | 2019-10-30 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins. Cell Rep, 29, 2019
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7BHF
| DARPin_D5/Her3 domain 4 complex, orthorhombic crystals | Descriptor: | ACETATE ION, DARPin_D5, Isoform 4 of Receptor tyrosine-protein kinase erbB-3 | Authors: | Mittl, P.R.E, Radom, F, Pluckthun, A. | Deposit date: | 2021-01-11 | Release date: | 2021-11-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5. Acta Crystallogr.,Sect.F, 77, 2021
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7BHE
| DARPin_D5/Her3 domain 4 complex, monoclinic crystals | Descriptor: | ACETATE ION, DARPin_D5, GLYCEROL, ... | Authors: | Mittl, P.R.E, Radom, F, Pluckthun, A. | Deposit date: | 2021-01-11 | Release date: | 2021-11-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.297 Å) | Cite: | Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5. Acta Crystallogr.,Sect.F, 77, 2021
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6S9N
| Designed Armadillo Repeat protein Lock2 fused to target peptide KRKRKAKLSF | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Lock2_KRKRKAKLSF | Authors: | Ernst, P, Zosel, F, Reichen, C, Schuler, B, Pluckthun, A. | Deposit date: | 2019-07-15 | Release date: | 2020-02-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. Acs Chem.Biol., 15, 2020
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6S9L
| Designed Armadillo Repeat protein Lock1 bound to (KR)4KLSF target | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, KR4KLSF Lock1, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-LEU-SER-PHE | Authors: | Ernst, P, Zosel, F, Reichen, C, Schuler, B, Pluckthun, A. | Deposit date: | 2019-07-15 | Release date: | 2020-02-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. Acs Chem.Biol., 15, 2020
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6S9O
| Designed Armadillo Repeat protein internal Lock1 fused to target peptide KRKRKLKFKR | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, designed Armadillo repeat protein with internal Lock1 fused to target peptide KRKRKLKFKR | Authors: | Ernst, P, Zosel, F, Reichen, C, Schuler, B, Pluckthun, A. | Deposit date: | 2019-07-15 | Release date: | 2020-02-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. Acs Chem.Biol., 15, 2020
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6S9M
| Designed Armadillo Repeat protein Lock2 fused to target peptide KRKRKAKITW | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Lock2_KRKRKAKITW, ... | Authors: | Ernst, P, Zosel, F, Reichen, C, Schuler, B, Pluckthun, A. | Deposit date: | 2019-07-15 | Release date: | 2020-02-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. Acs Chem.Biol., 15, 2020
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6S9P
| Designed Armadillo Repeat protein internal Lock2 fused to target peptide KRKAKITWKR | Descriptor: | 1,2-ETHANEDIOL, internal Lock2 fused to target peptide KRKAKITWKR | Authors: | Ernst, P, Zosel, F, Reichen, C, Schuler, B, Pluckthun, A. | Deposit date: | 2019-07-15 | Release date: | 2020-02-19 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Guided Design of a Peptide Lock for Modular Peptide Binders. Acs Chem.Biol., 15, 2020
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6SH9
| EngBF DARPin Fusion 4b D12 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-alpha-N-acetylgalactosaminidase,DARPin 4b D12, ... | Authors: | Ernst, P, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2019-08-06 | Release date: | 2019-11-06 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of biological targets by host:guest crystal lattice engineering. Sci Rep, 9, 2019
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6S9T
| Dimerization domain of Xenopus laevis LDB1 in complex with darpin 3 | Descriptor: | Darpin 3, LIM domain-binding protein 1, TETRAETHYLENE GLYCOL | Authors: | Renko, M, Schaefer, J.V, Pluckthun, A, Bienz, M. | Deposit date: | 2019-07-15 | Release date: | 2019-10-09 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proc.Natl.Acad.Sci.USA, 116, 2019
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6S9S
| Dimerization domain of Xenopus laevis LDB1 in complex with darpin 10 | Descriptor: | Darpin 10, LIM domain-binding protein 1 | Authors: | Renko, M, Schaefer, J.V, Pluckthun, A, Bienz, M. | Deposit date: | 2019-07-15 | Release date: | 2019-10-09 | Last modified: | 2019-10-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome. Proc.Natl.Acad.Sci.USA, 116, 2019
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8OH7
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6TPK
| Crystal structure of the human oxytocin receptor | Descriptor: | (3~{R},6~{R})-6-[(2~{S})-butan-2-yl]-3-(2,3-dihydro-1~{H}-inden-2-yl)-1-[(1~{R})-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxidanylidene-ethyl]piperazine-2,5-dione, CHOLESTEROL, DI(HYDROXYETHYL)ETHER, ... | Authors: | Waltenspuehl, Y, Schoeppe, J, Ehrenmann, J, Kummer, L, Plueckthun, A. | Deposit date: | 2019-12-13 | Release date: | 2020-08-05 | Last modified: | 2020-09-02 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of the human oxytocin receptor. Sci Adv, 6, 2020
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