1GML
| crystal structure of the mouse CCT gamma apical domain (triclinic) | Descriptor: | GLYCEROL, T-COMPLEX PROTEIN 1 SUBUNIT GAMMA | Authors: | Pappenberger, G, Wilsher, J.A, Roe, S.M, Willison, K.R, Pearl, L.H. | Deposit date: | 2001-09-17 | Release date: | 2002-06-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin J.Mol.Biol., 318, 2002
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1H0C
| The crystal structure of human alanine:glyoxylate aminotransferase | Descriptor: | (AMINOOXY)ACETIC ACID, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Zhang, X, Danpure, C.J, Roe, S.M, Pearl, L.H. | Deposit date: | 2002-06-17 | Release date: | 2003-06-12 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1. J.Mol.Biol., 331, 2003
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3ZDI
| Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d | Descriptor: | 3,6-Diamino-4-(2-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarbonitrile, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA, ... | Authors: | Oberholzer, A.E, Pearl, L.H. | Deposit date: | 2012-11-27 | Release date: | 2012-12-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.645 Å) | Cite: | 3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3) J.Med.Chem., 56, 2013
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3ZVL
| The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | Descriptor: | ACETATE ION, BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, CHLORIDE ION, ... | Authors: | Garces, F, Pearl, L.H, Oliver, A.W. | Deposit date: | 2011-07-25 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Structural Basis for Substrate Recognition by Mammalian Polynucleotide Kinase 3' Phosphatase. Mol.Cell, 44, 2011
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3ZVN
| The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | Descriptor: | 5'-D(*GP*TP*CP*AP*CP)-3', ADENOSINE-5'-DIPHOSPHATE, BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE, ... | Authors: | Garces, F, Pearl, L.H, Oliver, A.W. | Deposit date: | 2011-07-25 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase. Mol. Cell, 44, 2011
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1GS0
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1H8F
| Glycogen Synthase Kinase 3 beta. | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCOGEN SYNTHASE KINASE-3 BETA | Authors: | Dajani, R, Pearl, L.H, Roe, S.M. | Deposit date: | 2001-02-05 | Release date: | 2002-01-31 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Glycogen Synthase Kinase 3Beta . Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition Cell(Cambridge,Mass.), 105, 2001
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3ZVM
| The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-D(*GP*TP*CP*AP*CP)-3', ACETATE ION, ... | Authors: | Garces, F, Pearl, L.H, Oliver, A.W. | Deposit date: | 2011-07-25 | Release date: | 2011-11-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase. Mol. Cell, 44, 2011
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1HK7
| Middle Domain of HSP90 | Descriptor: | CADMIUM ION, HEAT SHOCK PROTEIN HSP82, MAGNESIUM ION | Authors: | Meyer, P, Prodromou, C, Roe, S.M, Pearl, L.H. | Deposit date: | 2003-03-06 | Release date: | 2004-01-29 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions Mol.Cell, 11, 2003
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4AV1
| Crystal structure of the human PARP-1 DNA binding domain in complex with DNA | Descriptor: | 5'-D(*AP*AP*GP*TP*GP*TP*TP*GP*CP*AP*TP*TP)-3', 5'-D(*TP*AP*AP*TP*GP*CP*AP*AP*CP*AP*CP*TP)-3', POLY [ADP-RIBOSE] POLYMERASE 1, ... | Authors: | Ali, A.A.E, Timinszky, G, Arribas-Bosacoma, R, Kozlowski, M, Hassa, P.O, Hassler, M, Ladurner, A.G, Pearl, L.H, Oliver, A.W. | Deposit date: | 2012-05-23 | Release date: | 2012-06-13 | Last modified: | 2012-07-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks Nat.Struct.Mol.Biol., 19, 2012
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4BA9
| The structural basis for the coordination of Y-family Translesion DNA Polymerases by Rev1 | Descriptor: | DNA POLYMERASE KAPPA, DNA REPAIR PROTEIN REV1, MAGNESIUM ION, ... | Authors: | Grummitt, C.G, Kilkenny, M.L, Frey, A, Roe, S.M, Oliver, A.W, Sale, J.E, Pearl, L.H. | Deposit date: | 2012-09-12 | Release date: | 2013-09-25 | Last modified: | 2017-03-15 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | The Structural Basis for the Coordination of Y- Family Translesion DNA Polymerases by Rev1 To be Published
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4BB7
| Crystal structure of the yeast Rsc2 BAH domain | Descriptor: | CHLORIDE ION, CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC2, GLYCEROL, ... | Authors: | Chambers, A.L, Pearl, L.H, Oliver, A.W, Downs, J.A. | Deposit date: | 2012-09-20 | Release date: | 2013-08-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Bah Domain of Rsc2 is a Histone H3 Binding Domain. Nucleic Acids Res., 41, 2013
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4B7T
| Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4 | Descriptor: | (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-3-methyl-2-(propan-2-ylamino)imidazol-4-one, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA | Authors: | Oberholzer, A.E, Pearl, L.H. | Deposit date: | 2012-08-22 | Release date: | 2013-01-30 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.772 Å) | Cite: | Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B. J.Med.Chem., 55, 2012
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4BMD
| Crystal structure of S.pombe Rad4 BRCT3,4 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4 | Authors: | Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-05-07 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BU1
| Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | Descriptor: | 1,2-ETHANEDIOL, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | Authors: | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-06-19 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BMC
| Crystal structure of s.pombe Rad4 BRCT1,2 | Descriptor: | CHLORIDE ION, S-M CHECKPOINT CONTROL PROTEIN RAD4 | Authors: | Meng, Q, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-05-07 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.982 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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4BU0
| Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide | Descriptor: | ACETATE ION, DNA REPAIR PROTEIN RHP9, GLYCEROL, ... | Authors: | Qu, M, Rappas, M, Wardlaw, C.P, Garcia, V, Carr, A.M, Oliver, A.W, Du, L.L, Pearl, L.H. | Deposit date: | 2013-06-19 | Release date: | 2013-10-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Phosphorylation-Dependent Assembly and Coordination of the DNA Damage Checkpoint Apparatus by Rad4(Topbp1.). Mol.Cell, 51, 2013
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2C2L
| Crystal structure of the CHIP U-box E3 ubiquitin ligase | Descriptor: | CARBOXY TERMINUS OF HSP70-INTERACTING PROTEIN, HSP90, NICKEL (II) ION, ... | Authors: | Zhang, M, Roe, S.M, Pearl, L.H. | Deposit date: | 2005-09-29 | Release date: | 2005-11-23 | Last modified: | 2019-05-15 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Chaperoned Ubiquitylation-Crystal Structures of the Chip U Box E3 Ubiquitin Ligase and a Chip-Ubc13-Uev1A Complex Mol.Cell, 20, 2005
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2C5L
| Structure of PLC epsilon Ras association domain with hRas | Descriptor: | GLYCEROL, GTPASE HRAS, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Roe, S.M, Bunney, T.D, Katan, M, Pearl, L.H. | Deposit date: | 2005-10-27 | Release date: | 2006-02-20 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon Mol.Cell, 21, 2006
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2BRF
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1KCF
| Crystal Structure of the Yeast Mitochondrial Holliday Junction Resolvase, Ydc2 | Descriptor: | HYPOTHETICAL 30.2 KD PROTEIN C25G10.02 IN CHROMOSOME I, SULFATE ION | Authors: | Ceschini, S, Keeley, A, McAlister, M.S.B, Oram, M, Phelan, J, Pearl, L.H, Tsaneva, I.R, Barrett, T.E. | Deposit date: | 2001-11-08 | Release date: | 2001-11-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2. EMBO J., 20, 2001
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2BYE
| NMR solution structure of phospholipase c epsilon RA 1 domain | Descriptor: | PHOSPHOLIPASE C, EPSILON 1 | Authors: | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | Deposit date: | 2005-08-01 | Release date: | 2006-02-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon. Mol.Cell, 21, 2006
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2BYF
| NMR solution structure of phospholipase c epsilon RA 2 domain | Descriptor: | PHOSPHOLIPASE C, EPSILON 1 | Authors: | Bunney, T.D, Harris, R, Gandarillas, N.L, Josephs, M.B, Roe, S.M, Paterson, H.F, Rodrigues-Lima, F, Esposito, D, Gieschik, P, Pearl, L.H, Driscoll, P.C, Katan, M. | Deposit date: | 2005-08-01 | Release date: | 2006-02-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural and Mechanistic Insights Into Ras Association Domains of Phospholipase C Epsilon. Mol.Cell, 21, 2006
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2BRC
| Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90. | Descriptor: | 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | Authors: | Roe, S.M, Pearl, L.H, Prodromou, C. | Deposit date: | 2005-05-04 | Release date: | 2005-09-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg. Med. Chem. Lett., 15, 2005
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2BRE
| STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90. | Descriptor: | 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 | Authors: | Roe, S.M, Pearl, L.H, Prodromou, C. | Deposit date: | 2005-05-04 | Release date: | 2005-09-29 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg. Med. Chem. Lett., 15, 2005
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