8VIC
 
 | | AP-6 bound human TMEM175 | | Descriptor: | (2P,2'P)-2,2'-(1,3-phenylene)di(pyridin-4-amine), Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2024-01-03 | | Release date: | 2024-08-14 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Discovery of Selective Inhibitors for the Lysosomal Parkinson's Disease Channel TMEM175.
J.Am.Chem.Soc., 146, 2024
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8VIE
 | | 2-PPA bound human TMEM175 | | Descriptor: | 2-phenylpyridin-4-amine, Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2024-01-04 | | Release date: | 2024-08-14 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Discovery of Selective Inhibitors for the Lysosomal Parkinson's Disease Channel TMEM175.
J.Am.Chem.Soc., 146, 2024
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6WCA
 | | Human closed state TMEM175 in KCl | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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6WC9
 | | Human open state TMEM175 in KCl | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.64 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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6WCB
 | | Human open state TMEM175 in CsCl | | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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6WCC
 | | Human closed state TMEM175 in CsCl | | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | | Authors: | Oh, S, Paknejad, N, Hite, R.K. | | Deposit date: | 2020-03-30 | | Release date: | 2020-04-15 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175.
Elife, 9, 2020
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8DHM
 | | Human TMEM175 in complex with 4-aminopyridine | | Descriptor: | 4-AMINOPYRIDINE, Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2022-06-27 | | Release date: | 2022-11-23 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8YG0
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7UNL
 | | Human TMEM175 in an open state | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2022-04-11 | | Release date: | 2022-06-01 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175.
Elife, 11, 2022
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7UNM
 | | Human TMEM175 in an closed state | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | | Authors: | Oh, S, Hite, R.K. | | Deposit date: | 2022-04-11 | | Release date: | 2022-06-29 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175.
Elife, 11, 2022
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6CTF
 | | Crystal structure of GltPh fast mutant - R276S/M395R | | Descriptor: | ASPARTIC ACID, Glutamate transporter homolog, SODIUM ION | | Authors: | Boudker, O, Oh, S. | | Deposit date: | 2018-03-23 | | Release date: | 2018-10-10 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (4.05 Å) | | Cite: | Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh.
Elife, 7, 2018
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5CFY
 | | CRYSTAL STRUCTURE OF GLTPH R397A IN COMPLEX WITH NA+ AND L-ASP | | Descriptor: | 425aa long hypothetical proton glutamate symport protein, ASPARTIC ACID, SODIUM ION | | Authors: | Boudker, O, Oh, S. | | Deposit date: | 2015-07-08 | | Release date: | 2016-04-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Elife, 3, 2014
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4OYE
 | | Crystal structure of GltPh R397A in apo | | Descriptor: | 425aa long hypothetical proton glutamate symport protein | | Authors: | Boudker, O, Oh, S. | | Deposit date: | 2014-02-11 | | Release date: | 2014-09-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Elife, 3, 2014
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4OYF
 | | Crystal structure of GLTPH R397A IN Sodium-bound state | | Descriptor: | GLUTAMATE SYMPORT PROTEIN, SODIUM ION | | Authors: | Boudker, O, Oh, S, Verdon, G, Serio, R. | | Deposit date: | 2014-02-11 | | Release date: | 2014-08-13 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | Coupled ion binding and structural transitions along the transport cycle of glutamate transporters.
Elife, 3, 2014
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7Y1H
 | | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | | Descriptor: | 1-(5-chloranyl-4-methyl-benzimidazol-1-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ... | | Authors: | Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y. | | Deposit date: | 2022-06-08 | | Release date: | 2023-07-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
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7Y1W
 | | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | | Descriptor: | (2R,3S)-2-[3-[4,5-bis(chloranyl)benzimidazol-1-yl]propyl]piperidin-3-ol, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ... | | Authors: | Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y. | | Deposit date: | 2022-06-09 | | Release date: | 2023-07-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
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7Y28
 | | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | | Descriptor: | 1-[6-(3-fluorophenyl)benzimidazol-1-yl]-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ... | | Authors: | Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y. | | Deposit date: | 2022-06-09 | | Release date: | 2023-07-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
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7Y3S
 | | Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1 | | Descriptor: | 1-(6-bromanyl-7-methyl-imidazo[4,5-b]pyridin-3-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, Bifunctional glutamate/proline--tRNA ligase, ... | | Authors: | Kim, S, Yoon, I, Son, J, Park, S, Hwang, K.Y. | | Deposit date: | 2022-06-12 | | Release date: | 2023-07-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1.
Embo Mol Med, 15, 2023
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7SI6
 | | Structure of ATP7B in state 1 | | Descriptor: | MAGNESIUM ION, P-type Cu(+) transporter, TETRAFLUOROALUMINATE ION | | Authors: | Bitter, R.M, Oh, S.C, Hite, R.K, Yuan, P. | | Deposit date: | 2021-10-12 | | Release date: | 2022-03-16 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Structure of the Wilson disease copper transporter ATP7B.
Sci Adv, 8, 2022
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7SI7
 | | Structure of ATP7B in state 2 | | Descriptor: | MAGNESIUM ION, P-type Cu(+) transporter, TETRAFLUOROALUMINATE ION | | Authors: | Bitter, R.M, Oh, S.C, Hite, R.K, Yuan, P. | | Deposit date: | 2021-10-12 | | Release date: | 2022-03-16 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Structure of the Wilson disease copper transporter ATP7B.
Sci Adv, 8, 2022
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7SI3
 | | Consensus structure of ATP7B | | Descriptor: | MAGNESIUM ION, P-type Cu(+) transporter, TETRAFLUOROALUMINATE ION | | Authors: | Bitter, R.M, Oh, S.C, Hite, R.K, Yuan, P. | | Deposit date: | 2021-10-12 | | Release date: | 2022-03-16 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structure of the Wilson disease copper transporter ATP7B.
Sci Adv, 8, 2022
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8DGS
 | | Cryo-EM structure of a RAS/RAF complex (state 1) | | Descriptor: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | | Authors: | Eck, M.J, Jeon, H, Park, E, Rawson, S. | | Deposit date: | 2022-06-24 | | Release date: | 2023-07-05 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
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8DGT
 | | Cryo-EM structure of a RAS/RAF complex (state 2) | | Descriptor: | 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ... | | Authors: | Eck, M.J, Jeon, H, Park, E, Rawson, S. | | Deposit date: | 2022-06-24 | | Release date: | 2023-07-05 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
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6NZZ
 | | LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A | | Authors: | Kern, D.M, Hite, R.K, Brohawn, S.G. | | Deposit date: | 2019-02-14 | | Release date: | 2019-02-27 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
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6O00
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