1AIE
 
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1GES
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1GEU
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1GET
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7BHF
 | | DARPin_D5/Her3 domain 4 complex, orthorhombic crystals | | 分子名称: | ACETATE ION, DARPin_D5, Isoform 4 of Receptor tyrosine-protein kinase erbB-3 | | 著者 | Mittl, P.R.E, Radom, F, Pluckthun, A. | | 登録日 | 2021-01-11 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5.
Acta Crystallogr.,Sect.F, 77, 2021
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7BHE
 | | DARPin_D5/Her3 domain 4 complex, monoclinic crystals | | 分子名称: | ACETATE ION, DARPin_D5, GLYCEROL, ... | | 著者 | Mittl, P.R.E, Radom, F, Pluckthun, A. | | 登録日 | 2021-01-11 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.297 Å) | | 主引用文献 | Crystal structures of HER3 extracellular domain 4 in complex with the designed ankyrin-repeat protein D5.
Acta Crystallogr.,Sect.F, 77, 2021
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2DKO
 | | Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis | | 分子名称: | Caspase-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | | 著者 | Mittl, P.R.E, Ganesan, R, Jelakovic, S, Grutter, M.G. | | 登録日 | 2006-04-12 | | 公開日 | 2006-07-04 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.06 Å) | | 主引用文献 | Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-ray Structure Analysis
J.Mol.Biol., 359, 2006
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8A1A
 | | Structure of a leucinostatin derivative determined by host lattice display : L1F11V1 construct | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2-methoxyethoxy)-11,15-dimethyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, ... | | 著者 | Mittl, P.R.E. | | 登録日 | 2022-06-01 | | 公開日 | 2022-12-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Acta Crystallogr D Struct Biol, 78, 2022
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8A19
 | | Structure of a leucinostatin derivative determined by host lattice display : L1E4V1 construct | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2-methoxyethoxy)-11,15-dimethyl-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, ... | | 著者 | Mittl, P.R.E. | | 登録日 | 2022-06-01 | | 公開日 | 2022-12-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.358 Å) | | 主引用文献 | Structure of a hydrophobic leucinostatin derivative determined by host lattice display.
Acta Crystallogr D Struct Biol, 78, 2022
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5OD1
 | | Structure of the engineered metalloesterase MID1sc10 complexed with a phosphonate transition state analogue | | 分子名称: | GLYCEROL, MID1sc10, ZINC ION, ... | | 著者 | Mittl, P.R.E, Studer, S, Hansen, D.A, Hilvert, D. | | 登録日 | 2017-07-04 | | 公開日 | 2018-12-12 | | 最終更新日 | 2020-04-22 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Evolution of a highly active and enantiospecific metalloenzyme from short peptides.
Science, 362, 2018
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8QBC
 | | Reactive amide intermediate in sperm whale myoglobin mutant H64V V68A | | 分子名称: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Tinzl, M, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2023-08-24 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | | 主引用文献 | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
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8QBA
 | | Sperm whale myoblogin mutant H64V V68A in complex with glycine ethyl ester | | 分子名称: | ACETATE ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Tinzl, M, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2023-08-24 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | | 主引用文献 | Myoglobin-Catalyzed Azide Reduction Proceeds via an Anionic Metal Amide Intermediate.
J.Am.Chem.Soc., 146, 2024
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7QNP
 | | Designed Armadillo repeat protein N(A4)M4C(AII) co-crystallized with hen egg white lysozyme | | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Designed Armadillo Repeat Protein N(A4)M4C(AII), ... | | 著者 | Michel, E, Mittl, P.R.E, Plueckthun, A. | | 登録日 | 2021-12-21 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.586 Å) | | 主引用文献 | Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design.
Biochemistry, 62, 2023
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6QEV
 | | EngBF DARPin Fusion 4b B6 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, MANGANESE (II) ION, PEGA domain-containing protein,PEGA domain-containing protein,EngBF DARPin fusion B6 complex, ... | | 著者 | Ernst, P, Pluckthun, A, Mittl, P.R.E. | | 登録日 | 2019-01-08 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-04-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
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6QFK
 | | EngBF DARPin Fusion 4b G10 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | 著者 | Ernst, P, Pluckthun, A, Mittl, P.R.E. | | 登録日 | 2019-01-10 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
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7AQH
 | | Cell wall binding domain of the Staphylococcal phage 2638A endolysin | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ORF007 | | 著者 | Dunne, M, Sobieraj, A, Ernst, P, Mittl, P.R.E, Pluckthun, A, Loessner, M.J. | | 登録日 | 2020-10-21 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Cell wall binding domain of the Staphylococcal phage 2638A endolysin
To Be Published
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2CJX
 | | Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis | | 分子名称: | CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | | 著者 | Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G. | | 登録日 | 2006-04-09 | | 公開日 | 2006-06-27 | | 最終更新日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
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2CJY
 | | Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis | | 分子名称: | CASPASE-3, PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | | 著者 | Ganesan, R, Mittl, P.R.E, Jelakovic, S, Grutter, M.G. | | 登録日 | 2006-04-09 | | 公開日 | 2006-06-27 | | 最終更新日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Extended Substrate Recognition in Caspase-3 Revealed by High Resolution X-Ray Structure Analysis
J.Mol.Biol., 359, 2006
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6QEP
 | | EngBF DARPin Fusion 4b H14 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ... | | 著者 | Ernst, P, Pluckthun, A, Mittl, P.R.E. | | 登録日 | 2019-01-08 | | 公開日 | 2019-11-06 | | 最終更新日 | 2020-04-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
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6QFO
 | | EngBF DARPin Fusion 9b 3G124 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MANGANESE (II) ION, ... | | 著者 | Ernst, P, Pluckthun, A, Mittl, P.R.E. | | 登録日 | 2019-01-10 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
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6SA7
 | | DARPin-Armadillo fusion C8long83 | | 分子名称: | DARPin-Armadillo fusion C8long83 | | 著者 | Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A. | | 登録日 | 2019-07-16 | | 公開日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
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6SA8
 | | ring-like DARPin-Armadillo fusion H83_D01 | | 分子名称: | 1,2-ETHANEDIOL, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG, ring-like DARPin-Armadillo fusion H83_D01 | | 著者 | Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A. | | 登録日 | 2019-07-16 | | 公開日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
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6SH9
 | | EngBF DARPin Fusion 4b D12 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-alpha-N-acetylgalactosaminidase,DARPin 4b D12, ... | | 著者 | Ernst, P, Pluckthun, A, Mittl, P.R.E. | | 登録日 | 2019-08-06 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural analysis of biological targets by host:guest crystal lattice engineering.
Sci Rep, 9, 2019
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6SA6
 | | DARPin-Armadillo fusion A5 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DARPin-Armadillo fusion A5 | | 著者 | Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Pluckthun, A. | | 登録日 | 2019-07-16 | | 公開日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
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4BS0
 | | Crystal Structure of Kemp Eliminase HG3.17 E47N,N300D Complexed with Transition State Analog 6-Nitrobenzotriazole | | 分子名称: | 6-NITROBENZOTRIAZOLE, KEMP ELIMINASE HG3.17, SULFATE ION | | 著者 | Blomberg, R, Kries, H, Pinkas, D.M, Mittl, P.R.E, Gruetter, M.G, Privett, H.K, Mayo, S, Hilvert, D. | | 登録日 | 2013-06-06 | | 公開日 | 2013-10-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Precision is Essential for Efficient Catalysis in an Evolved Kemp Eliminase
Nature, 503, 2013
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