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CDPK1 from Eimeria tenella in complex with inhibitor UW1354
Descriptor:	1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-19
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

4YZB

CDPK1 from Eimeria tenella in complex with inhibitor UW1521
Descriptor:	4-(6-ethoxynaphthalen-2-yl)-6-(piperazin-1-ylmethyl)-2H-indazol-3-amine, CALCIUM ION, Calmodulin-like domain protein kinase
Authors:	Merritt, E.A.
Deposit date:	2015-03-24
Release date:	2016-04-06
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	CDPK is a druggable target in the apicomplexan parasite Eimeria to be published

1LUG

Full Matrix Error Analysis of Carbonic Anhydrase
Descriptor:	(4-SULFAMOYL-PHENYL)-THIOCARBAMIC ACID O-(2-THIOPHEN-3-YL-ETHYL) ESTER, Carbonic Anhydrase II, GLYCEROL, ...
Authors:	Merritt, E.A, Le Trong, I, Behnke, C.A.
Deposit date:	2002-05-22
Release date:	2003-09-09
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (0.95 Å)
Cite:	Atomic resolution studies of carbonic anhydrase II. Acta Crystallogr.,Sect.D, 66, 2010

1VJQ

Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability.
Descriptor:	designed protein
Authors:	Merritt, E.A, Baker, D, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2004-03-19
Release date:	2004-03-30
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.098 Å)
Cite:	Designed protein based on backbone conformation of procarboxypeptidase-A (1AYE) with sidechains chosen for maximal predicted stability. To be Published

3HFD

Nucleosome Assembly Protein 1 from Plasmodium knowlesi
Descriptor:	Nucleosome assembly protein 1
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-05-11
Release date:	2009-05-26
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Nucleosome Assembly Protein 1 from Plasmodium knowlesi To be Published

3I05

Tryptophanyl-tRNA synthetase from Trypanosoma brucei
Descriptor:	Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-24
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3I7F

Aspartyl tRNA synthetase from Entamoeba histolytica
Descriptor:	Aspartyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-07-08
Release date:	2009-07-21
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol.Biochem.Parasitol., 169, 2010

3HZR

Tryptophanyl-tRNA synthetase homolog from Entamoeba histolytica
Descriptor:	Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-24
Release date:	2009-07-28
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3HRI

Histidyl-tRNA synthetase (apo) from Trypanosoma brucei
Descriptor:	Histidyl-tRNA synthetase
Authors:	Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-09
Release date:	2009-12-01
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J.Mol.Biol., 397, 2010

3HV0

Tryptophanyl-tRNA synthetase from Cryptosporidium parvum
Descriptor:	TRYPTOPHAN, Tryptophanyl-tRNA synthetase
Authors:	Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-15
Release date:	2009-06-30
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.42 Å)
Cite:	Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011

3HRK

Histidyl-tRNA synthetase from Trypanosoma cruzi (Histidyl-adenylate complex)
Descriptor:	CHLORIDE ION, HISTIDYL-ADENOSINE MONOPHOSPHATE, Histidyl-tRNA synthetase
Authors:	Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2009-06-09
Release date:	2009-12-01
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (3.05 Å)
Cite:	Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J.Mol.Biol., 397, 2010

3DWR

Leishmania major coproporphyrinogen III oxidase with bound ligand
Descriptor:	ACETATE ION, Coproporphyrinogen III oxidase, cyclopentylacetic acid
Authors:	Le Trong, I, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2008-07-22
Release date:	2008-09-09
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.66 Å)
Cite:	Leishmania major coproporphyrinogen III oxidase with bound ligand To be Published

3DWS

Leishmania major Coproporphyrinogen III Oxidase with bound ligand
Descriptor:	5-fluoroindole-2-carboxylic acid, ACETATE ION, Coproporphyrinogen III oxidase
Authors:	Le Trong, I, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2008-07-22
Release date:	2008-09-09
Last modified:	2017-10-25
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Leishmania major Coproporphyrinogen III Oxidase with bound ligand To be Published

1EEI

CHOLERA TOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYL-ALPHA-D-GALACTOSE
Descriptor:	3-nitrophenyl alpha-D-galactopyranoside, PROTEIN (CHOLERA TOXIN B)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2000-01-31
Release date:	2000-02-16
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr.,Sect.D, 57, 2001

1EFI

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH PARA-AMINOPHENYL-ALPHA-D-GALACTOPYRANOSIDE
Descriptor:	4-aminophenyl alpha-D-galactopyranoside, PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN)
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2000-02-08
Release date:	2000-02-23
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr.,Sect.D, 57, 2001

1EEF

HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH BOUND LIGAND PEPG
Descriptor:	2-PHENETHYL-2,3-DIHYDRO-PHTHALAZINE-1,4-DIONE, PROTEIN (HEAT-LABILE ENTEROTOXIN B CHAIN), alpha-D-galactopyranose
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2000-01-31
Release date:	2000-02-16
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr.,Sect.D, 57, 2001

1JQY

HEAT-LABILE ENTEROTOXIN B-PENTAMER WITH LIGAND BMSC-0010
Descriptor:	(3-NITRO-5-(3-MORPHOLIN-4-YL-PROPYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE, HEAT-LABILE ENTEROTOXIN B CHAIN
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2001-08-09
Release date:	2002-05-08
Last modified:	2017-10-04
Method:	X-RAY DIFFRACTION (2.14 Å)
Cite:	Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chem.Biol., 9, 2002

1JR0

CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0011
Descriptor:	(3-NITRO-5-(2-MORPHOLIN-4-YL-ETHYLAMINOCARBONYL)PHENYL)-GALACTOPYRANOSIDE, cholera toxin B subunit
Authors:	Merritt, E.A, Hol, W.G.J.
Deposit date:	2001-08-09
Release date:	2002-05-08
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chem.Biol., 9, 2002

3P0I

Leishmania major Tyrosyl-tRNA synthetase in complex with tyrosinol, cubic crystal form
Descriptor:	4-[(2S)-2-amino-3-hydroxypropyl]phenol, Tyrosyl-tRNA synthetase
Authors:	Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:	2010-09-28
Release date:	2011-03-23
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (3.13 Å)
Cite:	The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011

3LJN

Ankyrin repeat protein from Leishmania major
Descriptor:	hypothetical protein
Authors:	Holmes, M.A, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2010-01-26
Release date:	2010-02-09
Last modified:	2017-11-01
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Ankyrin repeat protein from Leishmania major To be Published

3KSV

Hypothetical protein from Leishmania major
Descriptor:	Uncharacterized protein, ZINC ION
Authors:	Han, G.W, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2009-11-23
Release date:	2010-01-12
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Hypothetical protein (HIT family) from Leishmania major To be Published

3KPA

Ubiquitin fold modifier conjugating enzyme from Leishmania major (probable)
Descriptor:	probable Ubiquitin fold modifier conjugating enzyme
Authors:	Han, G.W, Le Trong, I, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2009-11-16
Release date:	2009-12-01
Last modified:	2023-11-22
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Ubiquitin fold modifier conjugating enzyme from Leishmania major (probable) To be Published

2PGF

Crystal structure of adenosine deaminase from Plasmodium vivax in complex with adenosine
Descriptor:	ACETONITRILE, ADENOSINE, ZINC ION, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-04-09
Release date:	2007-04-24
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (1.89 Å)
Cite:	Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381, 2008

2PGR

Crystal structure of adenosine deaminase from Plasmodium vivax in complex with pentostatin
Descriptor:	2'-DEOXYCOFORMYCIN, ACETONITRILE, ZINC ION, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-04-10
Release date:	2007-04-24
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J.Mol.Biol., 381, 2008

3BJE

Crystal structure of Trypanosoma brucei nucleoside phosphorylase shows uridine phosphorylase activity
Descriptor:	1-O-phosphono-alpha-D-ribofuranose, CALCIUM ION, Nucleoside phosphorylase, ...
Authors:	Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:	2007-12-03
Release date:	2007-12-18
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.44 Å)
Cite:	The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase J.Mol.Biol., 396, 2010

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