4AE4
 
 | | The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain | | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, GLYCEROL, POTASSIUM ION, ... | | Authors: | Agromayor, M, Soler, N, Caballe, A, Kueck, T, Freund, S.M, Allen, M.D, Bycroft, M, Perisic, O, Ye, Y, McDonald, B, Scheel, H, Hofmann, K, Neil, S.J.D, Martin-Serrano, J, Williams, R.L. | | Deposit date: | 2012-01-06 | | Release date: | 2012-03-21 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
Structure, 20, 2012
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2WHV
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 (ALL CATION BINDING SITES OCCUPIED BY CALCIUM) | | Descriptor: | CADHERIN-23, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-05-07 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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2WCP
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 | | Descriptor: | CADHERIN-23, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-03-13 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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2WBX
 | | Crystal structure of mouse cadherin-23 EC1 | | Descriptor: | CADHERIN-23, CALCIUM ION | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-03-05 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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2WD0
 | | CRYSTAL STRUCTURE OF NONSYNDROMIC DEAFNESS (DFNB12) ASSOCIATED MUTANT D124G OF MOUSE CADHERIN-23 EC1-2 | | Descriptor: | CADHERIN-23, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2009-03-18 | | Release date: | 2010-04-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Neuron, 66, 2010
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4AQE
 | | CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2S70P AND PROTOCADHERIN-15 EC1-2 FORM I | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-16 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4APX
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM I | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-07 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4AQA
 | | CRYSTAL STRUCTURE OF DEAFNESS ASSOCIATED MUTANT MOUSE CADHERIN-23 EC1- 2D124G AND PROTOCADHERIN-15 EC1-2 FORM I | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-15 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4AXW
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2, FORM I 2.2A. | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CADHERIN-23, CALCIUM ION, ... | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-06-14 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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4AQ8
 | | CRYSTAL STRUCTURE OF MOUSE CADHERIN-23 EC1-2 AND PROTOCADHERIN-15 EC1- 2 FORM II | | Descriptor: | CADHERIN-23, CALCIUM ION, PROTOCADHERIN-15 | | Authors: | Sotomayor, M, Weihofen, W, Gaudet, R, Corey, D.P. | | Deposit date: | 2012-04-13 | | Release date: | 2012-11-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.63 Å) | | Cite: | Structure of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction
Nature, 492, 2012
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8V1O
 | | Crystal structure of IRAK4 kinase domain with compound 4 | | Descriptor: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | | Authors: | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | Deposit date: | 2023-11-21 | | Release date: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.92 Å) | | Cite: | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma
J.Med.Chem., 2024
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8V2L
 | | Crystal structure of IRAK4 kinase domain with compound 8 | | Descriptor: | 1,2-ETHANEDIOL, Interleukin-1 receptor-associated kinase 4, N-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | | Authors: | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | Deposit date: | 2023-11-22 | | Release date: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma
J.Med.Chem., 2024
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8V2F
 | | Crystal structure of IRAK4 kinase domain with compound 9 | | Descriptor: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | | Authors: | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | | Deposit date: | 2023-11-22 | | Release date: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma
J.Med.Chem., 2024
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4WZX
 | | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins | | Descriptor: | COBALT (II) ION, IST1 homolog, SULFATE ION, ... | | Authors: | Caballe, A, Wenzel, D.M, Agromayor, M, Alam, S.L, Skalicky, J.J, Kloc, M, Carlton, J.G, Labrador, L, Sundquist, W.I, Martin-Serrano, J. | | Deposit date: | 2014-11-20 | | Release date: | 2015-06-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.3859 Å) | | Cite: | ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.
Elife, 4, 2015
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5WJ8
 | | Crystal Structure of Human Cadherin-23 EC13-14 | | Descriptor: | CALCIUM ION, CHLORIDE ION, Cadherin-23, ... | | Authors: | Velez-Cortes, F, Conghui, C, De-la-Torre, P, Sotomayor, M. | | Deposit date: | 2017-07-21 | | Release date: | 2018-07-04 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Structure, 26, 2018
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6NW1
 | | Crystal Structure Desulfovibrio desulfuricans Nickel-Substituted Rubredoxin V37N | | Descriptor: | NICKEL (II) ION, Rubredoxin | | Authors: | Slater, J.W, Marguet, S.C, Gray, M.E, Sotomayor, M, Shafaat, H.S. | | Deposit date: | 2019-02-05 | | Release date: | 2019-08-14 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | The Power of the Secondary Sphere: Modulating Hydrogenase Activity in Nickel-Substituted Rubredoxin
Acs Catalysis, 2019
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5WJM
 | | Crystal Structure of Mouse Cadherin-23 EC17-18 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Cadherin-23, ... | | Authors: | De-la-Torre, P, Sotomayor, M. | | Deposit date: | 2017-07-23 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Structure, 26, 2018
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6ULM
 | | Crystal structure of human cadherin 17 EC1-2 | | Descriptor: | CALCIUM ION, Cadherin-17 | | Authors: | Gray, M.E, Sotomayor, M. | | Deposit date: | 2019-10-08 | | Release date: | 2021-03-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism.
Acta Crystallogr.,Sect.F, 77, 2021
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7N86
 | | Crystal Structure of Human Protocadherin-24 EC1-2 Form II | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Modak, D, Gray, M.E, Sotomayor, M. | | Deposit date: | 2021-06-13 | | Release date: | 2021-09-01 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.175 Å) | | Cite: | Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent.
Plos Biol., 19, 2021
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7N4P
 | | Crystal Structure of Lizard Cadherin-23 EC1-2 | | Descriptor: | CALCIUM ION, Cadherin 23, SODIUM ION | | Authors: | Nisler, C.R, Sotomayor, M. | | Deposit date: | 2021-06-04 | | Release date: | 2022-06-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.097 Å) | | Cite: | Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation.
Mol.Biol.Evol., 40, 2023
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7U71
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7UQU
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2YMB
 | | Structures of MITD1 | | Descriptor: | CHARGED MULTIVESICULAR BODY PROTEIN 1A, MIT DOMAIN-CONTAINING PROTEIN 1 | | Authors: | Hadders, M.A, Agromayor, M, Obita, T, Perisic, O, Caballe, A, Kloc, M, Lamers, M.H, Williams, R.L, Martin-Serrano, J. | | Deposit date: | 2012-10-08 | | Release date: | 2012-10-24 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.404 Å) | | Cite: | Escrt-III Binding Protein Mitd1 is Involved in Cytokinesis and Has an Unanticipated Pld Fold that Binds Membranes.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6OAE
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4XHZ
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