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Solution structures of full-length K-RAS bound to GDP
Descriptor:	Isoform 2B of GTPase KRas
Authors:	Sharma, A.K, Maciag, A.E.
Deposit date:	2020-12-09
Release date:	2022-06-15
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Solution structures of full-length K-RAS bound to GDP To Be Published

Crystal structure of active KRAS-G12C (GMPPNP-bound) in complex with BBO-8520
Descriptor:	BBO-8520 (bound form), GTPase KRas, MAGNESIUM ION, ...
Authors:	Chan, A.H, Ashraf, M, Dharmaiah, S, Simanshu, D.K.
Deposit date:	2023-11-27
Release date:	2024-12-18
Last modified:	2025-03-12
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C. Cancer Discov, 15, 2025

Crystal structure of KRAS-G12C (GDP-bound) in complex with BBO-8520
Descriptor:	BBO-8520 (bound form), GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:	Chan, A.H, Bratcher, D.R, Simanshu, D.K.
Deposit date:	2023-11-27
Release date:	2024-12-18
Last modified:	2025-03-12
Method:	X-RAY DIFFRACTION (1.67 Å)
Cite:	Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C. Cancer Discov, 15, 2025