6NNA
| Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and Compound 22 | Descriptor: | 1,2-ETHANEDIOL, Fatty acid synthase,Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Toms, A.V, Martin, M.W. | Deposit date: | 2019-01-14 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN). Bioorg. Med. Chem. Lett., 29, 2019
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6O2Z
| Crystal structure of IDH1 R132H mutant in complex with compound 32 | Descriptor: | 6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile, GLYCEROL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | Authors: | Toms, A.V, Lin, J. | Deposit date: | 2019-02-25 | Release date: | 2019-06-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J.Med.Chem., 62, 2019
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6O2Y
| Crystal structure of IDH1 R132H mutant in complex with compound 24 | Descriptor: | 4-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methoxybenzonitrile, BETA-MERCAPTOETHANOL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | Authors: | Toms, A.V, Lin, J. | Deposit date: | 2019-02-25 | Release date: | 2019-06-26 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J.Med.Chem., 62, 2019
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6PLX
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, desensitized state | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLZ
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, closed state | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLY
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, open state | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLR
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with glycine in nanodisc, desensitized state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, Glycine receptor subunit alphaZ1, ... | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2021-07-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLO
| CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA,open state | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLT
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with taurine in nanodisc, closed state | Descriptor: | 2-AMINOETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1, ... | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2021-07-21 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLU
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in nanodisc, desensitized state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, ... | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLV
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in nanodisc, closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, ... | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLS
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with taurine in nanodisc, desensitized state | Descriptor: | 2-AMINOETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1, ... | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-01-06 | Last modified: | 2021-07-21 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLQ
| CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA, super-open state | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM1
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, desensitized state | Descriptor: | 2-AMINOETHANESULFONIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM0
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, super-open state | Descriptor: | 2-AMINOETHANESULFONIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM4
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, super-open state | Descriptor: | GLYCINE, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM3
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, closed state | Descriptor: | 2-AMINOETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycine receptor subunit alphaZ1 | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM2
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Taurine in SMA, open state | Descriptor: | 2-AMINOETHANESULFONIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM5
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, desensitized state | Descriptor: | GLYCINE, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PM6
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with Glycine in SMA, open state | Descriptor: | GLYCINE, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2021-08-25 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLP
| CryoEM structure of zebra fish alpha-1 glycine receptor YGF mutant bound with GABA in SMA, desensitized state | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6PLW
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, super-open state | Descriptor: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yu, J, Zhu, H, Gouaux, E. | Deposit date: | 2019-07-01 | Release date: | 2021-02-10 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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3HQT
| PLP-Dependent Acyl-CoA Transferase CqsA | Descriptor: | CAI-1 autoinducer synthase, PYRIDOXAL-5'-PHOSPHATE | Authors: | Kelly, R.C, Jeffrey, P.D, Hughson, F.M. | Deposit date: | 2009-06-08 | Release date: | 2009-10-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol., 5, 2009
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3KKI
| PLP-Dependent Acyl-CoA transferase CqsA | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CAI-1 autoinducer synthase, MAGNESIUM ION, ... | Authors: | Kelly, R.C, Jeffrey, P.D, Hughson, F.M. | Deposit date: | 2009-11-05 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat.Chem.Biol., 5, 2009
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6TV4
| CFF-Notum complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CAFFEINE, DIMETHYL SULFOXIDE, ... | Authors: | Zhao, Y, Jones, E.Y. | Deposit date: | 2020-01-08 | Release date: | 2020-10-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Caffeine inhibits Notum activity by binding at the catalytic pocket. Commun Biol, 3, 2020
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