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Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST
Descriptor:	Mast/stem cell growth factor receptor Kit, ~{N}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine
Authors:	Graedler, U, Lammens, A.
Deposit date:	2022-05-19
Release date:	2023-02-22
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.119 Å)
Cite:	Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors. J.Med.Chem., 66, 2023

Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST
Descriptor:	5-imidazo[1,2-a]pyridin-3-yl-~{N}-[(1~{R})-1-(6-pyrrolidin-1-ylpyridin-3-yl)ethyl]pyridin-3-amine, HUMAN PROTO-ONCOGENE C-KIT
Authors:	Graedler, U, Lammens, A.
Deposit date:	2022-05-24
Release date:	2023-02-22
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (3.09 Å)
Cite:	Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors. J.Med.Chem., 66, 2023

Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein
Descriptor:	Darpin, SODIUM ION, Tumor necrosis factor receptor superfamily member 5
Authors:	Malvezzi, F, Mangold, S, Hospodarsch, T, Reichen, C, Iss, C, Lammens, A, Krapp, S, Domke, C.
Deposit date:	2021-07-07
Release date:	2022-04-06
Last modified:	2022-05-11
Method:	X-RAY DIFFRACTION (2.29 Å)
Cite:	A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression. Cancer Immunol Res, 10, 2022

Human jak1 kinase domain in complex with inhibitor
Descriptor:	Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide
Authors:	Read, J.A, Augustin, M, Lammens, A.
Deposit date:	2018-05-03
Release date:	2019-05-22
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling To Be Published