1SS9
 
 | | Crystal Structural Analysis of Active Site Mutant Q189E of LgtC | | 分子名称: | MANGANESE (II) ION, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUOROGALACTOSE, alpha-1,4-galactosyl transferase | | 著者 | Lairson, L.L, Chiu, C.P, Ly, H.D, He, S, Wakarchuk, W.W, Strynadka, N.C, Withers, S.G. | | 登録日 | 2004-03-23 | | 公開日 | 2004-09-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Intermediate trapping on a mutant retaining alpha-galactosyltransferase identifies an unexpected aspartate residue.
J.Biol.Chem., 279, 2004
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6XNN
 | | Crystal Structure of Mouse STING CTD complex with SR-717. | | 分子名称: | 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, Stimulator of interferon genes protein | | 著者 | Chin, E.N, Yu, C, Wolan, D.W, Petrassi, H.M, Lairson, L.L. | | 登録日 | 2020-07-03 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Science, 369, 2020
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6XNP
 | | Crystal Structure of Human STING CTD complex with SR-717 | | 分子名称: | 1,2-ETHANEDIOL, 4,5-difluoro-2-{[6-(1H-imidazol-1-yl)pyridazine-3-carbonyl]amino}benzoic acid, GLYCEROL, ... | | 著者 | Chin, E.N, Yu, C, Wolan, D.W, Petrassi, H.M, Lairson, L.L. | | 登録日 | 2020-07-03 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Science, 369, 2020
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2P2V
 | | Crystal structure analysis of monofunctional alpha-2,3-sialyltransferase Cst-I from Campylobacter jejuni | | 分子名称: | 1,2-ETHANEDIOL, Alpha-2,3-sialyltransferase, CHLORIDE ION, ... | | 著者 | Chiu, C.P, Lairson, L.L, Gilbert, M, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C. | | 登録日 | 2007-03-07 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural Analysis of the alpha-2,3-Sialyltransferase Cst-I from Campylobacter jejuni in Apo and Substrate-Analogue Bound Forms.
Biochemistry, 46, 2007
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2P56
 | | Crystal structure of alpha-2,3-sialyltransferase from Campylobacter jejuni in apo form | | 分子名称: | 1,2-ETHANEDIOL, Alpha-2,3-sialyltransferase | | 著者 | Chiu, C.P, Lairson, L.L, Gilbert, M, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C. | | 登録日 | 2007-03-14 | | 公開日 | 2007-07-10 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Analysis of the alpha-2,3-Sialyltransferase Cst-I from Campylobacter jejuni in Apo and Substrate-Analogue Bound Forms.
Biochemistry, 46, 2007
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1RO8
 | | Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analogue, cytidine-5'-monophosphate | | 分子名称: | CYTIDINE-5'-MONOPHOSPHATE, alpha-2,3/8-sialyltransferase | | 著者 | Chiu, C.P, Watts, A.G, Lairson, L.L, Gilbert, M, Lim, D, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C. | | 登録日 | 2003-12-01 | | 公開日 | 2004-02-03 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.
Nat.Struct.Mol.Biol., 11, 2004
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1RO7
 | | Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analogue, CMP-3FNeuAc. | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, alpha-2,3/8-sialyltransferase | | 著者 | Chiu, C.P, Watts, A.G, Lairson, L.L, Gilbert, M, Lim, D, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C. | | 登録日 | 2003-12-01 | | 公開日 | 2004-02-03 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog.
Nat.Struct.Mol.Biol., 11, 2004
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2X61
 | | Crystal structure of the sialyltransferase CST-II in complex with trisaccharide acceptor and CMP | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, ACETATE ION, ... | | 著者 | Lee, H.J, Lairson, L.L, Rich, J.R, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | | 登録日 | 2010-02-16 | | 公開日 | 2011-03-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
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2X62
 | | CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE CST-II Y81F IN COMPLEX WITH CMP | | 分子名称: | 1,2-ETHANEDIOL, ALPHA-2,3-/2,8-SIALYLTRANSFERASE, N3-PROTONATED CYTIDINE-5'-MONOPHOSPHATE | | 著者 | Lee, H.J, Lairson, L.L, Rich, J.R, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | | 登録日 | 2010-02-14 | | 公開日 | 2011-02-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
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2X63
 | | Crystal structure of the sialyltransferase CST-II N51A in complex with CMP | | 分子名称: | 1,2-ETHANEDIOL, ALPHA-2,3-/2,8-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE | | 著者 | Lee, H.J, Lairson, L.L, Rich, J.R, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J. | | 登録日 | 2010-02-14 | | 公開日 | 2011-02-23 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
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2WQQ
 | | Crystallographic analysis of monomeric CstII | | 分子名称: | ALPHA-2,3-/2,8-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, DI(HYDROXYETHYL)ETHER | | 著者 | Chan, P.H.W, Lairson, L.L, Lee, H.J, Wakarchuk, W.W, Strynadka, N.C.J, Withers, S.G, McIntosh, L.P. | | 登録日 | 2009-08-25 | | 公開日 | 2009-10-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | NMR Spectroscopic Characterization of the Sialyltransferase Cstii from Camplyobacter Jejuni: Histidine 188 is the General Base.
Biochemistry, 48, 2009
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6DNA
 | | Crystal structure of T110A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) | | 分子名称: | Aspartate aminotransferase, cytoplasmic, PYRIDOXAL-5'-PHOSPHATE, ... | | 著者 | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | | 登録日 | 2018-06-06 | | 公開日 | 2018-11-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57, 2018
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6DND
 | | Crystal structure of wild-type (WT) human Glutamate oxaloacetate transaminase 1 (GOT1) | | 分子名称: | Aspartate aminotransferase, cytoplasmic, PYRIDOXAL-5'-PHOSPHATE, ... | | 著者 | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | | 登録日 | 2018-06-06 | | 公開日 | 2018-11-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57, 2018
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6DNB
 | | Crystal structure of T110A:S256A mutant human Glutamate oxaloacetate transaminase 1 (GOT1) | | 分子名称: | Aspartate aminotransferase, cytoplasmic, GLYCEROL, ... | | 著者 | Assar, Z, Holt, M.C, Stein, A.J, Lairson, L, Lyssiotis, C.A. | | 登録日 | 2018-06-06 | | 公開日 | 2018-11-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.
Biochemistry, 57, 2018
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2DRJ
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2C83
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2C84
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