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Structure of E138K/G140A/Q148K HIV-1 intasome with Dolutegravir bound
分子名称:	(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ...
著者	Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D.
登録日	2022-12-27
公開日	2023-08-09
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023

HIV-1 Integrase Catalytic Core Domain in Complex with an Allosteric Inhibitor, 3-(1H-pyrrol-1-yl)-2-thiophenecarboxylic acid
分子名称:	3-pyrrol-1-ylthiophene-2-carboxylic acid, DIMETHYL SULFOXIDE, Integrase
著者	Patel, D, Bauman, J.D, Arnold, E.
登録日	2016-07-07
公開日	2016-09-28
最終更新日	2022-03-23
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J.Biol.Chem., 291, 2016

HIV-1 Integrase Catalytic Core Domain (CCD) in Complex with a Fragment-Derived Allosteric Inhibitor
分子名称:	3-[2,5-bis(chloranyl)pyrrol-1-yl]thiophene-2-carboxylic acid, Integrase
著者	Patel, D, Bauman, J.D, Arnold, E.
登録日	2016-07-07
公開日	2016-09-28
最終更新日	2019-12-25
実験手法	X-RAY DIFFRACTION (1.651 Å)
主引用文献	A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J.Biol.Chem., 291, 2016

Human Brd4 ET domain in complex with MLV Integrase C-term
分子名称:	Bromodomain-containing protein 4, MLV integrase
著者	Crowe, B.L, Foster, M.P.
登録日	2015-06-03
公開日	2016-03-02
最終更新日	2024-05-15
実験手法	SOLUTION NMR
主引用文献	Structure of the Brd4 ET domain bound to a C-terminal motif from gamma-retroviral integrases reveals a conserved mechanism of interaction. Proc.Natl.Acad.Sci.USA, 113, 2016