7C60
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![BU of 7c60 by Molmil](/molmil-images/mine/7c60) | Crystal structure of Keap1 in complex with monoethyl fumarate (MEF) | Descriptor: | (~{Z})-4-ethoxy-4-oxidanylidene-but-2-enoic acid, ACETATE ION, Kelch-like ECH-associated protein 1, ... | Authors: | Padmanabhan, B, Unni, S, Deshmukh, P, Krishnappa, G. | Deposit date: | 2020-05-21 | Release date: | 2020-08-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1. Febs J., 288, 2021
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6JKE
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![BU of 6jke by Molmil](/molmil-images/mine/6jke) | Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2. | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione, Bromodomain-containing protein 2, ... | Authors: | Padmanabhan, B, Mathur, S, Deshmukh, P. | Deposit date: | 2019-02-28 | Release date: | 2020-07-01 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Novel pyrano 1,3 oxazine based ligand inhibits the epigenetic reader hBRD2 in glioblastoma. Biochem.J., 477, 2020
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6LRZ
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![BU of 6lrz by Molmil](/molmil-images/mine/6lrz) | Crystal structure of Keap1 in complex with dimethyl fumarate (DMF) | Descriptor: | 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ACETATE ION, Keap1-DC, ... | Authors: | Padmanabhan, B, Unni, S, Deshmukh, P. | Deposit date: | 2020-01-16 | Release date: | 2020-08-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1. Febs J., 288, 2021
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7C5E
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![BU of 7c5e by Molmil](/molmil-images/mine/7c5e) | Crystal structure of Keap1 in complex with fumarate (FUM) | Descriptor: | ACETATE ION, FUMARIC ACID, Kelch-like ECH-associated protein 1, ... | Authors: | Padmanabhan, B, Unni, S, Deshmukh, P. | Deposit date: | 2020-05-19 | Release date: | 2020-08-05 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1. Febs J., 288, 2021
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7ENZ
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![BU of 7enz by Molmil](/molmil-images/mine/7enz) | Crystal structure of Phenanthredinone moiety in complex with the second bromodomain of BRD2 (BRD2-BD2). | Descriptor: | Bromodomain-containing protein 2, TRIETHYLENE GLYCOL, phenanthridin-6(5H)-one | Authors: | Padmanabhan, B, Arole, A, Deshmukh, P, Ashok, S. | Deposit date: | 2021-04-21 | Release date: | 2022-03-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains. Acta Crystallogr.,Sect.F, 78, 2022
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