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Cryo-EM structure of Mtb Lpd bound to inhibitor complex with 2-((2-cyano-N,5-dimethyl-1H-indole)-7-sulfonamido)-N-(4-(oxetan-3-yl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-7-yl)acetamide
Descriptor:	Dihydrolipoyl dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE, N~2~-(2-cyano-5-methyl-1H-indole-7-sulfonyl)-N~2~-methyl-N-[4-(oxetan-3-yl)-3,4-dihydro-2H-1,4-benzoxazin-7-yl]glycinamide
Authors:	Kochanczyk, T, Arango, N, Lima, C.D.
Deposit date:	2022-05-13
Release date:	2022-05-25
Last modified:	2024-06-12
Method:	ELECTRON MICROSCOPY (2.17 Å)
Cite:	Cryo-EM structure of Mtb Lpd bound to the inhibitor 2-((2-cyano-N,5-dimethyl-1H-indole)-7-sulfonamido)-N-(4-(oxetan-3-yl)-3,4-dihydro-2H-benzo[b] [1,4]oxazin-7-yl)acetamide at 2.17 Angstrom resolution Not published

9B5O

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 10 map and model from consensus
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (3.19 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5E

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 10 map and model from consensus
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.81 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B55

Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 1
Descriptor:	4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (3.23 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B58

Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 4
Descriptor:	4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (3.39 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5G

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 2 map and model (Ub(A)/ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.67 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5P

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 1 map and model (ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (3.08 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5W

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 1 map and model from cluster 5 (ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (3.96 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5D

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 1 map and model from consensus
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.8 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5J

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 5 map and model (Ub(A)-AMP)
Descriptor:	4-aminobutanenitrile, ADENOSINE MONOPHOSPHATE, Large ribosomal subunit protein eL40B, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.86 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5U

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 1 map and model from cluster 1 (ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (3.67 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5T

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 5 map and model (ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (3.16 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B57

Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 3
Descriptor:	4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (3.37 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5C

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - consensus map and model
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.5 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5N

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - Ub(T) class 1 map and model from consensus
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (3.12 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5R

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 3 map and model (ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (2.95 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B59

Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 5
Descriptor:	4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (3.49 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5L

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 10 map and model from cluster 5 (Ub(A)-AMP)
Descriptor:	4-aminobutanenitrile, ADENOSINE MONOPHOSPHATE, Polyubiquitin, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5K

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - Ub(T) class 1 map and model from cluster 1 (Ub(A)/ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, Large ribosomal subunit protein eL40B, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (3.16 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5A

Ubiquitin E2-Ub-E3 HECT tetrahedral transthiolation intermediate mimic - state 6
Descriptor:	4-aminobutanenitrile, E3 ubiquitin-protein ligase pub2, Ubiquitin, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (3.65 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5H

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 3 map and model (Ub(A)-AMP/PPi/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE MONOPHOSPHATE, Large ribosomal subunit protein eL40B, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.69 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5F

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 1 map and model (Ub(A)/ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.78 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5S

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 4 map and model (ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (2.96 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5I

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (doubly Ub-loaded) - cluster 4 map and model (Ub(A)-AMP/PPi/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-18
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

9B5Q

Ubiquitin E1-Ub-E2 tetrahedral transthiolation intermediate mimic (singly Ub-loaded) - cluster 2 map and model (ATP/Mg)
Descriptor:	4-aminobutanenitrile, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Kochanczyk, T, Lima, C.D.
Deposit date:	2024-03-22
Release date:	2024-06-05
Last modified:	2024-09-25
Method:	ELECTRON MICROSCOPY (2.95 Å)
Cite:	Structural basis for transthiolation intermediates in the ubiquitin pathway. Nature, 633, 2024

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Total results:	31
Displayed results:	25
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