7N2O
 
 | | AS4.2-YEIH-HLA*B27 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-05-29 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
|
|
7N2N
 | | TCR-antigen complex AS4.2-PRPF3-HLA*B27 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-05-29 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
|
|
7N2S
 | | AS3.1-PRPF3-HLA*B27 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-05-29 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
|
|
6NDZ
 | | Designed repeat protein in complex with Fz8 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ACETIC ACID, ... | | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | | Deposit date: | 2018-12-14 | | Release date: | 2019-05-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.264 Å) | | Cite: | Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6NE2
 | | Designed repeat protein in complex with Fz7 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | | Deposit date: | 2018-12-15 | | Release date: | 2019-05-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.299 Å) | | Cite: | Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6NE1
 | | Designed repeat protein in complex with Fz4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Pfs, ... | | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | | Deposit date: | 2018-12-15 | | Release date: | 2019-05-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.011 Å) | | Cite: | Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6NE4
 | | Designed repeat protein specifically in complex with Fz7CRD | | Descriptor: | 1,2-ETHANEDIOL, Designed repeat binding protein, Frizzled-7, ... | | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | | Deposit date: | 2018-12-16 | | Release date: | 2019-05-15 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.648 Å) | | Cite: | Receptor subtype discrimination using extensive shape complementary designed interfaces.
Nat.Struct.Mol.Biol., 26, 2019
|
|
6BGA
 | | 2B4 I-Ek TCR-MHC complex with affinity-enhancing Velcro peptide | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2B4 peptide,MHC I-Ek B chain, ... | | Authors: | Gee, M.H, Sibener, L.V, Birnbaum, M.E, Jude, K.M, Garcia, K.C. | | Deposit date: | 2017-10-27 | | Release date: | 2018-07-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.307 Å) | | Cite: | Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
8ENT
 | | Interleukin-21 signaling complex with IL-21R and IL-2Rg | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Abhiraman, G.C, Jude, K.M, Garcia, K.C. | | Deposit date: | 2022-09-30 | | Release date: | 2023-06-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | A structural blueprint for interleukin-21 signal modulation.
Cell Rep, 42, 2023
|
|
8G04
 | | Structure of signaling thrombopoietin-MPL receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ... | | Authors: | Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C. | | Deposit date: | 2023-01-31 | | Release date: | 2023-08-30 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Cell, 186, 2023
|
|
5T5W
 | | Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interferon lambda receptor 1, Interferon lambda-3, ... | | Authors: | Mendoza, J.L, Jude, K.M, Garcia, K.C. | | Deposit date: | 2016-08-31 | | Release date: | 2017-03-29 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.847 Å) | | Cite: | The IFN-lambda-IFN-lambda R1-IL-10R beta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.
Immunity, 46, 2017
|
|
7R86
 | | Structure of mouse BAI1 (ADGRB1) in complex with mouse Nogo receptor (RTN4R) | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-AMINOBENZOIC ACID, ... | | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-06-26 | | Release date: | 2021-11-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Cell, 184, 2021
|
|
7R85
 | | Structure of mouse Bai1 (ADGRB1) TSR3 domain | | Descriptor: | Vasculostatin-120, alpha-D-mannopyranose, beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose | | Authors: | Miao, Y, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-06-26 | | Release date: | 2021-11-10 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Cell, 184, 2021
|
|
7R84
 | |
7RKY
 | | Binding mode of US27-Gi-scFv16 in OCL-state | | Descriptor: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Tsutsumi, N, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
|
|
7RKN
 | | Structure of CX3CL1-US28-Gi-scFv16 in OC-state | | Descriptor: | Antibody fragment scFv16, Fractalkine, G-protein coupled receptor homolog US28, ... | | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
|
|
7RKX
 | | Structure of US27-Gi-scFv16 in CL-state | | Descriptor: | Antibody fragment scFv16, G-protein coupled receptor homolog US27, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Tsutsumi, N, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
|
|
7RKM
 | | Structure of CX3CL1-US28-Gi-scFv16 in C-state | | Descriptor: | Antibody fragment scFv16, CHOLESTEROL, Fractalkine, ... | | Authors: | Tsutsumi, N, Qu, Q, Jude, K.M, Skiniotis, G, Garcia, K.C. | | Deposit date: | 2021-07-22 | | Release date: | 2022-01-26 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins
Sci Adv, 8, 2022
|
|
7S2S
 | | nanobody bound to Interleukin-2Rbeta | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IL2Rb-binding nanobody, Interleukin-2 receptor subunit beta, ... | | Authors: | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | | Deposit date: | 2021-09-03 | | Release date: | 2022-03-30 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Facile discovery of surrogate cytokine agonists.
Cell, 185, 2022
|
|
7S2R
 | | nanobody bound to IL-2Rg | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | | Authors: | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | | Deposit date: | 2021-09-03 | | Release date: | 2022-03-30 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Facile discovery of surrogate cytokine agonists.
Cell, 185, 2022
|
|
7T6F
 | | Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain | | Descriptor: | ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, Interferon lambda receptor 1, ... | | Authors: | Glassman, C.R, Tsutsumi, N, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-12-13 | | Release date: | 2022-03-16 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.
Science, 376, 2022
|
|
7U7N
 | | IL-27 quaternary receptor signaling complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | | Authors: | Caveney, N.A, Glassman, C.R, Jude, K.M, Tsutsumi, N, Garcia, K.C. | | Deposit date: | 2022-03-07 | | Release date: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Structure of the IL-27 quaternary receptor signaling complex.
Elife, 11, 2022
|
|
7TR4
 | | MA2-MART1-HLAA0201 | | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA-A*02:01, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2022-01-27 | | Release date: | 2022-11-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy.
Nat.Biotechnol., 41, 2023
|
|
1BJU
 | | BETA-TRYPSIN COMPLEXED WITH ACPU | | Descriptor: | 1-(4-AMIDINOPHENYL)-3-(4-CHLOROPHENYL)UREA, BETA-TRYPSIN, CALCIUM ION, ... | | Authors: | Presnell, S, Patil, G, Mura, C, Jude, K, Conley, J, Kam, C, Bertrand, J, Powers, J, Williams, L. | | Deposit date: | 1998-06-29 | | Release date: | 1998-12-02 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
|
|
1BJV
 | | BETA-TRYPSIN COMPLEXED WITH APPU | | Descriptor: | 1-(2-AMIDINOPHENYL)-3-(PHENOXYPHENYL)UREA, BETA-TRYPSIN, CALCIUM ION, ... | | Authors: | Presnell, S, Patil, G, Mura, C, Jude, K, Conley, J, Kam, C, Bertrand, J, Powers, J, Williams, L. | | Deposit date: | 1998-06-29 | | Release date: | 1998-12-02 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Oxyanion-mediated inhibition of serine proteases.
Biochemistry, 37, 1998
|
|
