3GN4
 
 | | Myosin lever arm | | Descriptor: | CALCIUM ION, Calmodulin, MAGNESIUM ION, ... | | Authors: | Mukherjea, M, Llinas, P, Kim, H, Travaglia, M, Safer, D, Zong, A.B, Menetrey, J, Franzini-Armstrong, C, Selvin, P.R, Houdusse, A, Sweeney, H.L. | | Deposit date: | 2009-03-16 | | Release date: | 2009-09-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Myosin VI dimerization triggers an unfolding of a three-helix bundle in order to extend its reach
Mol.Cell, 35, 2009
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4ATU
 | | Human doublecortin N-DC repeat plus linker, and tubulin (2XRP) docked into an 8A cryo-EM map of doublecortin-stabilised microtubules reconstructed in absence of kinesin | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, NEURONAL MIGRATION PROTEIN DOUBLECORTIN, ... | | Authors: | Liu, J.S, Schubert, C.R, Fu, X, Fourniol, F.J, Jaiswal, J.K, Houdusse, A, Stultz, C.M, Moores, C.A, Walsh, C.A. | | Deposit date: | 2012-05-09 | | Release date: | 2012-09-26 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8.3 Å) | | Cite: | Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins.
Mol.Cell, 47, 2012
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5LE0
 | | MICAL1 Cterminal domain | | Descriptor: | Protein-methionine sulfoxide oxidase MICAL1 | | Authors: | Hammich, H, Pylypenko, O, Houdusse, A. | | Deposit date: | 2016-06-29 | | Release date: | 2017-03-01 | | Last modified: | 2017-03-08 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Oxidation of F-actin controls the terminal steps of cytokinesis.
Nat Commun, 8, 2017
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3L9I
 | | Myosin VI nucleotide-free (mdinsert2) L310G mutant crystal structure | | Descriptor: | ACETATE ION, CALCIUM ION, Calmodulin, ... | | Authors: | Pylypenko, O, Song, L, Sweeney, L.H, Houdusse, A. | | Deposit date: | 2010-01-05 | | Release date: | 2010-12-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Role of insert i of myosin VI in modulating nucleotide affinity
To be Published
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5JCZ
 | | Rab11 bound to MyoVa-GTD | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, BERYLLIUM TRIFLUORIDE ION, ... | | Authors: | Pylypenko, O, Attanda, W, Gauquelin, C, Malherbes, G, Houdusse, A. | | Deposit date: | 2016-04-15 | | Release date: | 2016-09-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.056 Å) | | Cite: | Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes.
Elife, 5, 2016
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5JCY
 | | Spir2-GTBM bound to MyoVa-GTD | | Descriptor: | Protein spire homolog 2, Unconventional myosin-Va | | Authors: | Pylypenko, O, Malherbes, G, Welz, T, Kerkhoff, E, Houdusse, A. | | Deposit date: | 2016-04-15 | | Release date: | 2016-09-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes.
Elife, 5, 2016
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5ND7
 | | Microtubule-bound MKLP2 motor domain in the presence of AMPPNP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... | | Authors: | Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. | | Deposit date: | 2017-03-07 | | Release date: | 2017-10-04 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
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5ND2
 | | Microtubule-bound MKLP2 motor domain in the presence of ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. | | Deposit date: | 2017-03-07 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
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5ND4
 | | Microtubule-bound MKLP2 motor domain in the presence of ADP.AlFx | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Atherton, J, Yu, I.-M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. | | Deposit date: | 2017-03-07 | | Release date: | 2017-10-04 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
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5ND3
 | | Microtubule-bound MKLP2 motor domain in the with no nucleotide | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF20A, ... | | Authors: | Atherton, J, Yu, I.M, Cook, A, Muretta, J.M, Joseph, A.P, Major, J, Sourigues, Y, Clause, J, Topf, M, Rosenfeld, S.S, Houdusse, A, Moores, C.A. | | Deposit date: | 2017-03-07 | | Release date: | 2017-10-04 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
Elife, 6, 2017
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4DBR
 | | Myosin VI D179Y (MD) pre-powerstroke state | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Pylypenko, O, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2012-01-16 | | Release date: | 2013-01-30 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Mutations in myosin VI that cause a loss of coordination between heads provide insights into the structural changes underlying force generation and the importance of gating
To be Published
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4DBP
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4DBQ
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2V26
 | | Myosin VI (MD) pre-powerstroke state (Mg.ADP.VO4) | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Menetrey, J, Llinas, P, Mukherjea, M, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2007-06-03 | | Release date: | 2007-11-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | The Structural Basis for the Large Powerstroke of Myosin Vi.
Cell(Cambridge,Mass.), 131, 2007
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2W83
 | | Crystal structure of the ARF6 GTPase in complex with a specific effector, JIP4 | | Descriptor: | 1,4-DIETHYLENE DIOXIDE, ADP-RIBOSYLATION FACTOR 6, C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4, ... | | Authors: | Isabet, T, Montagnac, G, Regazzoni, K, Raynal, B, El Khadali, F, Franco, M, England, P, Chavrier, P, Houdusse, A, Menetrey, J. | | Deposit date: | 2009-01-08 | | Release date: | 2009-07-14 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | The Structural Basis of Arf Effector Specificity: The Crystal Structure of Arf6 in a Complex with Jip4.
Embo J., 28, 2009
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5KG8
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5MV7
 | | Structure of human Myosin 7b C-terminal MyTH4-FERM MF2 domain | | Descriptor: | SULFATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE, Unconventional myosin-VIIb | | Authors: | Planelles-Herrero, V.J, Sourigues, Y, Titus, M.A, Houdusse, A. | | Deposit date: | 2017-01-15 | | Release date: | 2017-07-05 | | Last modified: | 2022-03-30 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Myosin 7 and its adaptors link cadherins to actin.
Nat Commun, 8, 2017
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5MV9
 | | Structure of human Myosin 7a C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain | | Descriptor: | ACETATE ION, Unconventional myosin-VIIa, cDNA FLJ51329, ... | | Authors: | Yu, I, Sourigues, Y, Titus, M.A, Houdusse, A. | | Deposit date: | 2017-01-16 | | Release date: | 2017-07-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Myosin 7 and its adaptors link cadherins to actin.
Nat Commun, 8, 2017
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5MV8
 | | Structure of human Myosin 7b C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain | | Descriptor: | GLYCEROL, MAGNESIUM ION, Unconventional myosin-VIIb, ... | | Authors: | Yu, I, Sourigues, Y, Titus, M.A, Houdusse, A. | | Deposit date: | 2017-01-16 | | Release date: | 2017-07-05 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Myosin 7 and its adaptors link cadherins to actin.
Nat Commun, 8, 2017
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5N69
 | | Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil | | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | Authors: | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | | Deposit date: | 2017-02-14 | | Release date: | 2017-08-16 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
Nat Commun, 8, 2017
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1OE9
 | | Crystal structure of Myosin V motor with essential light chain-nucleotide-free | | Descriptor: | MYOSIN LIGHT CHAIN 1, SLOW-TWITCH MUSCLE A ISOFORM, MYOSIN VA, ... | | Authors: | Coureux, P.-D, Wells, A.L, Menetrey, J, Yengo, C.M, Morris, C.A, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2003-03-21 | | Release date: | 2003-09-26 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | A Structural State of the Myosin V Motor without Bound Nucleotide
Nature, 425, 2003
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4PK4
 | | Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2014-05-13 | | Release date: | 2015-04-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.78 Å) | | Cite: | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
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4PJK
 | | Dicty myosin II R238E.E459R mutant (with ADP.Pi) in the Pi release state | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2014-05-12 | | Release date: | 2015-04-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
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4PFO
 | | Myosin VI motor domain in the Pi release state, space group P212121 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2014-04-30 | | Release date: | 2015-04-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
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4PJM
 | | Myosin VI motor domain in the Pi release state, space group P212121 - soaked with PO4 - located in the active site | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ISOPROPYL ALCOHOL, ... | | Authors: | Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A. | | Deposit date: | 2014-05-12 | | Release date: | 2015-04-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
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