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An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A
Descriptor:	(1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside, DNA (5'-D(GPCPTPAPTPAPGPC)-3')
Authors:	Woo, C.M, Li, Z, Paulson, E, Herzon, S.B.
Deposit date:	2015-11-07
Release date:	2016-06-01
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A. Proc.Natl.Acad.Sci.USA, 113, 2016

Crystal structure of a self resistance protein ClbS from colibactin biosynthetic gene cluster
Descriptor:	Colibactin self-protection protein ClbS
Authors:	Tripathi, P, Bruner, S.D.
Deposit date:	2017-08-14
Release date:	2018-06-27
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.098 Å)
Cite:	ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance. J. Am. Chem. Soc., 139, 2017

Crystal structure of ClbQ from the colibactin NRPS/PKS pathway
Descriptor:	BETA-MERCAPTOETHANOL, Putative thioesterase
Authors:	Guntaka, N.S, Bruner, S.D.
Deposit date:	2017-01-10
Release date:	2017-09-20
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.983 Å)
Cite:	Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway. ACS Chem. Biol., 12, 2017