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Benzopiperazine BET bromodomain inhibitor in complex with BD1 of Brd4
Descriptor:	3-[(2S)-1-acetyl-4-(furan-2-carbonyl)-2-methyl-1,2,3,4-tetrahydroquinoxalin-6-yl]-N-methylbenzamide, Bromodomain-containing protein 4
Authors:	Toms, A.V, Herbertz, T.
Deposit date:	2017-05-03
Release date:	2017-08-02
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.67 Å)
Cite:	Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains. ACS Med Chem Lett, 8, 2017

Crystal structure of Mcl-1 in complex with compound 65
Descriptor:	Induced myeloid leukemia cell differentiation protein Mcl-1, methyl N-(5-{[2-chloro-5-(trifluoromethyl)phenyl]sulfamoyl}-4-methylthiophene-2-carbonyl)-D-phenylalaninate
Authors:	Toms, A.V, Follows, B.
Deposit date:	2019-05-24
Release date:	2019-07-03
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.61 Å)
Cite:	Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors. Bioorg.Med.Chem.Lett., 29, 2019