8UF4
 
 | | Crystal structure of wildtype dystroglycan proteolytic domain (juxtamembrane domain) | | Descriptor: | Beta-dystroglycan, CALCIUM ION, CHLORIDE ION, ... | | Authors: | Anderson, M.J.M, Shi, K, Hayward, A.N, Uhlens, C, Evans III, R.L, Grant, E, Greenberg, L, Aihara, H, Gordon, W.R. | | Deposit date: | 2023-10-03 | | Release date: | 2024-09-11 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan.
Structure, 32, 2024
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1REG
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387D
 | | RNA Pseudoknot with 3D Domain Swapping | | Descriptor: | RNA Pseudoknot | | Authors: | Lietzke, S.E, Kundrot, C.E, Barnes, C.L. | | Deposit date: | 1998-04-14 | | Release date: | 2003-08-26 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The Structure of an RNA Pseudoknot Shows 3D Domain Swapping
Structure, Motion, Interaction and Expression of Biological Macromolecules, The Proceedings of the Tenth Conversation held at The University-SUNY, Albany NY, June 17-21, 1997, 10, 1998
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7G3F
 | | Crystal Structure of rat Autotaxin in complex with 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-3-methylimidazole-4-carbonitrile, i.e. SMILES c1c(c(cc(c1C(C)(C)C)OCC1=NC=C(N1C)C#N)Cl)C#N with IC50=0.0496453 microM | | Descriptor: | 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-1-methyl-1H-imidazole-5-carbonitrile, ACETATE ION, CALCIUM ION, ... | | Authors: | Stihle, M, Benz, J, Hunziker, D, Green, L, Rudolph, M.G. | | Deposit date: | 2023-06-05 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structure of a rat Autotaxin complex
To be published
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7G3V
 | | Crystal Structure of rat Autotaxin in complex with 5-tert-butyl-2-chloro-4-[[5-(6-methoxypyrimidin-4-yl)-1-methylimidazol-2-yl]methoxy]benzonitrile, i.e. SMILES c1c(c(cc(c1C(C)(C)C)OCC1=NC=C(N1C)c1cc(ncn1)OC)Cl)C#N with IC50=0.0417382 microM | | Descriptor: | 5-tert-butyl-2-chloro-4-{[(5M)-5-(6-methoxypyrimidin-4-yl)-1-methyl-1H-imidazol-2-yl]methoxy}benzonitrile, ACETATE ION, CALCIUM ION, ... | | Authors: | Stihle, M, Benz, J, Hunziker, D, Green, L, Rudolph, M.G. | | Deposit date: | 2023-06-05 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Crystal Structure of a rat Autotaxin complex
To be published
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7G3J
 | | Crystal Structure of rat Autotaxin in complex with 5-tert-butyl-2-chloro-4-[[1-methyl-5-(6-oxa-1-azaspiro[3.3]heptane-1-carbonyl)imidazol-2-yl]methoxy]benzonitrile, i.e. SMILES Clc1c(C#N)cc(C(C)(C)C)c(c1)OCC1=NC=C(C(=O)N2C3(CC2)COC3)N1C with IC50=0.124297 microM | | Descriptor: | 5-tert-butyl-2-chloro-4-{[1-methyl-5-(6-oxa-1-azaspiro[3.3]heptane-1-carbonyl)-1H-imidazol-2-yl]methoxy}benzonitrile, ACETATE ION, CALCIUM ION, ... | | Authors: | Stihle, M, Benz, J, Hunziker, D, Green, L, Rudolph, M.G. | | Deposit date: | 2023-06-05 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Crystal Structure of a rat Autotaxin complex
To be published
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7G3M
 | | Crystal Structure of rat Autotaxin in complex with 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-3-methyl-N-(oxetan-3-yl)imidazole-4-carboxamide, i.e. SMILES Clc1c(C#N)cc(C(C)(C)C)c(c1)OCC1=NC=C(C(=O)NC2COC2)N1C with IC50=0.0161695 microM | | Descriptor: | 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-1-methyl-N-(oxetan-3-yl)-1H-imidazole-5-carboxamide, ACETATE ION, CALCIUM ION, ... | | Authors: | Stihle, M, Benz, J, Hunziker, D, Green, L, Rudolph, M.G. | | Deposit date: | 2023-06-05 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal Structure of a rat Autotaxin complex
To be published
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7G3L
 | | Crystal Structure of rat Autotaxin in complex with 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-N,3-dimethylimidazole-4-carboxamide, i.e. SMILES Clc1c(C#N)cc(C(C)(C)C)c(c1)OCC1=NC=C(C(=O)NC)N1C with IC50=0.0853541 microM | | Descriptor: | 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-N,1-dimethyl-1H-imidazole-5-carboxamide, ACETATE ION, CALCIUM ION, ... | | Authors: | Stihle, M, Benz, J, Hunziker, D, Green, L, Rudolph, M.G. | | Deposit date: | 2023-06-05 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal Structure of a rat Autotaxin complex
To be published
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7G3Q
 | | Crystal Structure of rat Autotaxin in complex with 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-N-(1,1-dioxothietan-3-yl)-3-methylimidazole-4-carboxamide, i.e. SMILES Clc1c(C#N)cc(C(C)(C)C)c(c1)OCC1=NC=C(C(=O)NC2CS(=O)(=O)C2)N1C with IC50=0.0049749 microM | | Descriptor: | 2-[(2-tert-butyl-5-chloro-4-cyanophenoxy)methyl]-N-(1,1-dioxo-1lambda~6~-thietan-3-yl)-1-methyl-1H-imidazole-5-carboxamide, ACETATE ION, CALCIUM ION, ... | | Authors: | Stihle, M, Benz, J, Hunziker, D, Green, L, Rudolph, M.G. | | Deposit date: | 2023-06-05 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Crystal Structure of a rat Autotaxin complex
To be published
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7G3K
 | | Crystal Structure of rat Autotaxin in complex with 5-tert-butyl-2-chloro-4-[(7-methyl-8-oxo-5,6-dihydroimidazo[1,5-a]pyrazin-3-yl)methoxy]benzonitrile, i.e. SMILES c1c(c(cc(c1C(C)(C)C)OCC1=NC=C2N1CCN(C2=O)C)Cl)C#N with IC50=0.416172 microM | | Descriptor: | 5-tert-butyl-2-chloro-4-{[(4S)-7-methyl-8-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl]methoxy}benzonitrile, ACETATE ION, CALCIUM ION, ... | | Authors: | Stihle, M, Benz, J, Hunziker, D, Green, L, Rudolph, M.G. | | Deposit date: | 2023-06-05 | | Release date: | 2024-12-18 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Crystal Structure of a rat Autotaxin complex
To be published
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5D4D
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5D4C
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5D4E
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9DUV
 | | Cryo-EM structure of recombinant R254H ACTA1 phalloidin-stabilized F-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Garg, A, Greenberg, M.J, Zhang, R. | | Deposit date: | 2024-10-04 | | Release date: | 2024-10-23 | | Last modified: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9DUU
 | | Cryo-EM structure of recombinant wildtype ACTA1 phalloidin-stabilized F-actin | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | Authors: | Garg, A, Greenberg, M.J, Zhang, R. | | Deposit date: | 2024-10-04 | | Release date: | 2024-10-23 | | Last modified: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility.
Proc.Natl.Acad.Sci.USA, 121, 2024
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