1Y1M
 
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1Y1Z
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2A65
 | | Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters | | Descriptor: | CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ... | | Authors: | Yamashita, A, Singh, S.K, Kawate, T, Jin, Y, Gouaux, E. | | Deposit date: | 2005-07-01 | | Release date: | 2005-08-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of a bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters.
Nature, 437, 2005
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2A5S
 | | Crystal Structure Of The NR2A Ligand Binding Core In Complex With Glutamate | | Descriptor: | GLUTAMIC ACID, N-methyl-D-aspartate receptor NMDAR2A subunit | | Authors: | Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E. | | Deposit date: | 2005-06-30 | | Release date: | 2005-11-15 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
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2A5T
 | | Crystal Structure Of The NR1/NR2A ligand-binding cores complex | | Descriptor: | GLUTAMIC ACID, GLYCINE, N-methyl-D-aspartate receptor NMDAR1-4a subunit, ... | | Authors: | Furukawa, H, Singh, S.K, Mancusso, R, Gouaux, E. | | Deposit date: | 2005-06-30 | | Release date: | 2005-11-15 | | Last modified: | 2017-07-26 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Subunit arrangement and function in NMDA receptors
Nature, 438, 2005
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1MM7
 | | Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc Crystal Form at 1.65 Angstroms Resolution | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, ZINC ION | | Authors: | Jin, R, Horning, M, Mayer, M.L, Gouaux, E. | | Deposit date: | 2002-09-03 | | Release date: | 2003-02-04 | | Last modified: | 2017-08-02 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Mechanism of Activation and Selectivity in a Ligand-Gated Ion Channel: Structural and Functional Studies of GluR2 and Quisqualate
Biochemistry, 41, 2003
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1MM6
 | | crystal structure of the GluR2 ligand binding core (S1S2J) in complex with quisqualate in a non zinc crystal form at 2.15 angstroms resolution | | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, GLYCEROL, ... | | Authors: | Jin, R, Horning, M, Mayer, M.L, Gouaux, E. | | Deposit date: | 2002-09-03 | | Release date: | 2003-02-04 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Mechanism of activation and selectivity in a ligand-gated ion channel: Structural and functional studies of GluR2 and quisqualate
Biochemistry, 41, 2002
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4MM4
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4MM8
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4MMF
 | | Crystal structure of LeuBAT (delta5 mutant) in complex with mazindol | | Descriptor: | (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ... | | Authors: | Wang, H, Gouaux, E. | | Deposit date: | 2013-09-08 | | Release date: | 2013-10-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
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4MM9
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4MM5
 | | Crystal structure of LeuBAT (delta13 mutant) in complex with sertraline | | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter | | Authors: | Wang, H, Gouaux, E. | | Deposit date: | 2013-09-08 | | Release date: | 2013-10-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
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4MMB
 | | Crystal structure of LeuBAT (delta6 mutant) in complex with sertraline | | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter, ... | | Authors: | Wang, H, Gouaux, E. | | Deposit date: | 2013-09-08 | | Release date: | 2013-10-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
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4MMA
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4MM6
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4MME
 | | Crystal structure of LeuBAT (delta6 mutant) in complex with mazindol | | Descriptor: | (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ... | | Authors: | Wang, H, Gouaux, E. | | Deposit date: | 2013-09-08 | | Release date: | 2013-10-16 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for action by diverse antidepressants on biogenic amine transporters.
Nature, 503, 2013
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4MM7
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4MMC
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4MMD
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4NTW
 | | Structure of acid-sensing ion channel in complex with snake toxin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... | | Authors: | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | Deposit date: | 2013-12-02 | | Release date: | 2014-02-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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4NTY
 | | Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin | | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Acid-sensing ion channel 1, Basic phospholipase A2 homolog Tx-beta, ... | | Authors: | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | Deposit date: | 2013-12-02 | | Release date: | 2014-02-19 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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4NTX
 | | Structure of acid-sensing ion channel in complex with snake toxin and amiloride | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE, Acid-sensing ion channel 1, ... | | Authors: | Baconguis, I, Bohlen, C.J, Goehring, A, Julius, D, Gouaux, E. | | Deposit date: | 2013-12-02 | | Release date: | 2014-02-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Cell(Cambridge,Mass.), 156, 2014
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3F3A
 | | Crystal Structure of LeuT bound to L-Tryptophan and Sodium | | Descriptor: | SODIUM ION, TETRADECANE, TRYPTOPHAN, ... | | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | Deposit date: | 2008-10-30 | | Release date: | 2008-12-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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3F3D
 | | Crystal structure of LeuT bound to L-Methionine and sodium | | Descriptor: | METHIONINE, SODIUM ION, Transporter, ... | | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | Deposit date: | 2008-10-30 | | Release date: | 2008-12-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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3F3E
 | | Crystal structure of LeuT bound to L-leucine (30 mM) and sodium | | Descriptor: | LEUCINE, SODIUM ION, Transporter, ... | | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | | Deposit date: | 2008-10-30 | | Release date: | 2008-12-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation.
Science, 322, 2008
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