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Crystal Structure of the Aquifex Reactor Complex Formed by Dihydroorotase (H180A, H232A) with Dihydroorotate and Aspartate Transcarbamoylase with N-(phosphonacetyl)-L-aspartate (PALA)
分子名称:	(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, 1,2-ETHANEDIOL, ASPARTATE CARBAMOYLTRANSFERASE, ...
著者	Edwards, B.F.P, Martin, P.D, Grimley, E, Vaishnav, A, Fernando, R, Brunzelle, J.S, Cordes, M, Evans, H.G, Evans, D.R.
登録日	2013-04-18
公開日	2013-12-18
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	The Mononuclear Metal Center of Type-I Dihydroorotase from Aquifex Aeolicus. Bmc Biochem., 14, 2013

Crystal Structure of Aquifex Dihydroorotase Activated by Aspartate Transcarbamoylase
分子名称:	Aspartate carbamoyltransferase, CITRATE ANION, Dihydroorotase, ...
著者	Edwards, B.F.P.
登録日	2008-05-20
公開日	2009-01-20
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Dihydroorotase from the hyperthermophile Aquifiex aeolicus is activated by stoichiometric association with aspartate transcarbamoylase and forms a one-pot reactor for pyrimidine biosynthesis. Biochemistry, 48, 2009

PKM2 bound to compound 2
分子名称:	1,2-ETHANEDIOL, 3-[(3-aminophenyl)methyl]-5-methyl-7-[methyl(oxidanyl)-$l^{3}-sulfanyl]pyridazino[4,5-b]indol-4-one, MAGNESIUM ION, ...
著者	Stuckey, J.A.
登録日	2023-02-03
公開日	2023-05-17
最終更新日	2023-06-07
実験手法	X-RAY DIFFRACTION (1.838 Å)
主引用文献	Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis. Pharmaceuticals, 16, 2023