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CRYSTAL STRUCTURE OF HBV CAPSID Y132A MUTANT IN COMPLEX WITH N-(3-chloro-4-fluorophenyl)-3-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide AT 2.65A RESOLUTION
Descriptor:	Capsid protein, ISOPROPYL ALCOHOL, N-(3-chloro-4-fluorophenyl)-3-phenyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide
Authors:	Kuduk, S.D, Stoops, B, Alexander, R, Lam, A.M, Espiritu, C, Vogel, R, Lau, V, Klumpp, K, Flores, O.A, Hartman, G.D, Lukacs, C.M, Abendroth, J.
Deposit date:	2020-09-17
Release date:	2021-07-28
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Identification of a new class of HBV capsid assembly modulator. Bioorg.Med.Chem.Lett., 39, 2021

Crystal structure of the HBV capsid Y132A mutant (VCID 8772) in complex with NVR10-001E2 at 1.95A resolution
Descriptor:	Capsid protein, methyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)pyrimidine-5-carboxylate
Authors:	Lukacs, C.M, Abendroth, J, Klumpp, K.
Deposit date:	2015-09-28
Release date:	2015-12-09
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. Proc.Natl.Acad.Sci.USA, 112, 2015

Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24
Descriptor:	(6S,8R)-N-(3-bromo-4-fluorophenyl)-8-fluoro-10-methyl-11-oxo-1,3,4,7,8,9,10,11-octahydro-2H-pyrido[4',3':3,4]pyrazolo[1,5-a][1,4]diazepine-2-carboxamide, CHLORIDE ION, Capsid protein
Authors:	Shaffer, P.L.
Deposit date:	2023-03-14
Release date:	2023-04-12
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Diazepinone HBV capsid assembly modulators. Bioorg Med Chem Lett, 72, 2022