6PYB
 
 | | Sex Hormone-binding globulin mutant E176K in complex with DVT | | 分子名称: | 4,4'-[(3R,4R)-oxolane-3,4-diylbis(methylene)]bis(2-methoxyphenol), CALCIUM ION, Sex hormone-binding globulin | | 著者 | Round, P.W, Das, S, Van Petegem, F. | | 登録日 | 2019-07-29 | | 公開日 | 2019-12-25 | | 最終更新日 | 2020-02-12 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
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2ZSD
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with Coenzyme A | | 分子名称: | 1,2-ETHANEDIOL, COENZYME A, GLYCEROL, ... | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-05 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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2ZSA
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP and Phosphopantothenate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-04 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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2ZS7
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with citrate anion | | 分子名称: | CITRATE ANION, GLYCEROL, Pantothenate kinase, ... | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-03 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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2ZSB
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP, obtained through soaking of native enzyme crystals with the ligand | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Pantothenate kinase | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-04 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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2ZSE
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with AMPPCP and Pantothenate | | 分子名称: | 1,2-ETHANEDIOL, CITRATE ANION, GLYCEROL, ... | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-05 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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2ZSF
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ATP and ADP | | 分子名称: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-05 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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2ZS9
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with ADP and Pantothenate | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, PANTOTHENOIC ACID, ... | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-04 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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2ZS8
 | | Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) co-crystallized with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Pantothenate kinase | | 著者 | Chetnani, B, Das, S, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2008-09-03 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mycobacterium tuberculosis pantothenate kinase: possible changes in location of ligands during enzyme action
Acta Crystallogr.,Sect.D, 65, 2009
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4I4N
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2MI1
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7TN2
 | | Composite model of a Chd1-nucleosome complex in the nucleotide-free state derived from 2.3A and 2.7A Cryo-EM maps | | 分子名称: | Chromo domain-containing protein 1, DNA Lagging Strand, DNA Tracking Strand, ... | | 著者 | Nodelman, I.M, Bowman, G.D, Armache, J.-P. | | 登録日 | 2022-01-20 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state.
Nat.Struct.Mol.Biol., 29, 2022
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7SWY
 | | 2.6 A structure of a 40-601[TA-rich+1]-40 nucleosome | | 分子名称: | DNA Guide Strand, DNA Tracking Strand, Histone H2A, ... | | 著者 | Nodelman, I.M, Bowman, G.D, Armache, J.-P. | | 登録日 | 2021-11-21 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-03-29 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Nucleosome recognition and DNA distortion by the Chd1 remodeler in a nucleotide-free state.
Nat.Struct.Mol.Biol., 29, 2022
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6CHZ
 | | Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224. | | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, Estrogen receptor | | 著者 | Larsen, N.A. | | 登録日 | 2018-02-23 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.
Cancer Discov, 8, 2018
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6CHW
 | | Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942. | | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide, DIMETHYL SULFOXIDE, ... | | 著者 | Larsen, N.A. | | 登録日 | 2018-02-23 | | 公開日 | 2018-03-21 | | 最終更新日 | 2020-02-26 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.
Cancer Discov, 8, 2018
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6YFY
 | | Solid-state NMR structure of the D-Arg4,L10-teixobactin - Lipid II complex in lipid bilayers. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-N-acetyl-alpha-muramic acid, 3-methylbut-2-en-1-ol, D-Arg4,Leu10-Teixobactin, ... | | 著者 | Weingarth, M.H, Shukla, R. | | 登録日 | 2020-03-26 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Mode of action of teixobactins in cellular membranes.
Nat Commun, 11, 2020
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7DK1
 | | Crystal structure of Zinc bound SARS-CoV-2 main protease | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3C-like proteinase, CHLORIDE ION, ... | | 著者 | Sonkar, K.S, Panchariya, L, Kuila, S, Khan, W.A, Arockiasamy, A. | | 登録日 | 2020-11-22 | | 公開日 | 2021-06-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | Zinc 2+ ion inhibits SARS-CoV-2 main protease and viral replication in vitro.
Chem.Commun.(Camb.), 57, 2021
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6SDG
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6WWB
 | | Crystal Structure of the second bromodomain of human BRD2 in complex with the compound 3b | | 分子名称: | 1,2-ETHANEDIOL, 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide, Bromodomain-containing protein 2 | | 著者 | White, S.W, Yun, M. | | 登録日 | 2020-05-08 | | 公開日 | 2021-11-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Angew.Chem.Int.Ed.Engl., 60, 2021
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8P09
 | | 48S late-stage initiation complex with non methylated mRNA | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | 著者 | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | | 登録日 | 2023-05-09 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Mol.Cell, 84, 2024
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8P03
 | | 48S late-stage initiation complex with m6A mRNA | | 分子名称: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | 著者 | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | | 登録日 | 2023-05-09 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Mol.Cell, 84, 2024
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5XLW
 | | Mycobacterium tuberculosis Pantothenate kinase mutant F247A/F254A | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... | | 著者 | Paul, A, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2017-05-11 | | 公開日 | 2018-05-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Biochemical and structural studies of mutants indicate concerted movement of the dimer interface and ligand-binding region of Mycobacterium tuberculosis pantothenate kinase
Acta Crystallogr F Struct Biol Commun, 73, 2017
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5XLV
 | | Mycobacterium tuberculosis Pantothenate kinase mutant F254A | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Pantothenate kinase, ... | | 著者 | Paul, A, Kumar, P, Surolia, A, Vijayan, M. | | 登録日 | 2017-05-11 | | 公開日 | 2018-05-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Biochemical and structural studies of mutants indicate concerted movement of the dimer interface and ligand-binding region of Mycobacterium tuberculosis pantothenate kinase
Acta Crystallogr F Struct Biol Commun, 73, 2017
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5YIY
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5YIT
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