5LT3
 
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5LT1
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5LT0
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5LT2
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5LT4
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4LNU
 | | Nucleotide-free kinesin motor domain in complex with tubulin and a DARPin | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Designed ankyrin repeat protein (DARPIN) D1, GLYCEROL, ... | | 著者 | Cao, L, Gigant, B, Knossow, M. | | 登録日 | 2013-07-12 | | 公開日 | 2014-12-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement
Nat Commun, 5, 2014
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6JHR
 | | The cryo-EM structure of HAV bound to a neutralizing antibody-F6 | | 分子名称: | FAB Heavy Chain, FAB Light Chain, VP1, ... | | 著者 | Cao, L, Liu, P, Yang, P, Gao, Q, Li, H, Sun, Y, Zhu, L, Lin, J, Su, D, Rao, Z, Wang, X. | | 登録日 | 2019-02-18 | | 公開日 | 2020-03-18 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors.
Plos Biol., 17, 2019
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6JHT
 | | The cryo-EM structure of HAV bound to a neutralizing antibody-F9 | | 分子名称: | FAB Heavy Chain, FAB Light Chain, VP1, ... | | 著者 | Cao, L, Liu, P, Yang, P, Gao, Q, Li, H, Sun, Y, Zhu, L, Lin, J, Su, D, Rao, Z, Wang, X. | | 登録日 | 2019-02-19 | | 公開日 | 2020-03-18 | | 実験手法 | ELECTRON MICROSCOPY (3.79 Å) | | 主引用文献 | Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors.
Plos Biol., 17, 2019
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6JHQ
 | | The cryo-EM structure of HAV bound to a neutralizing antibody-F4 | | 分子名称: | FAB Heavy Chain, FAB Light Chain, VP1, ... | | 著者 | Cao, L, Liu, P, Yang, P, Gao, Q, Li, H, Sun, Y, Zhu, L, Lin, J, Su, D, Rao, Z, Wang, X. | | 登録日 | 2019-02-18 | | 公開日 | 2020-03-18 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors.
Plos Biol., 17, 2019
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6JHS
 | | The cryo-EM structure of HAV bound to a neutralizing antibody-F7 | | 分子名称: | FAB Heavy Chain, FAB Light Chain, VP1, ... | | 著者 | Cao, L, Liu, P, Yang, P, Gao, Q, Li, H, Sun, Y, Zhu, L, Lin, J, Su, D, Rao, Z, Wang, X. | | 登録日 | 2019-02-19 | | 公開日 | 2020-03-18 | | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | | 主引用文献 | Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors.
Plos Biol., 17, 2019
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8KHD
 | | The interface structure of Omicron RBD binding to 5817 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 5817, Light chain of 5817, ... | | 著者 | Cao, L, Wang, X. | | 登録日 | 2023-08-21 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain.
Cell Rep, 43, 2024
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8KHC
 | | SARS-CoV-2 Omicron spike in complex with 5817 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 5817 Fab, ... | | 著者 | Cao, L, Wang, X. | | 登録日 | 2023-08-21 | | 公開日 | 2024-04-17 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain.
Cell Rep, 43, 2024
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7N3T
 | | TrkA ECD complex with designed miniprotein ligand | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jude, K.M, Cao, L, Garcia, K.C. | | 登録日 | 2021-06-01 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Design of protein-binding proteins from the target structure alone.
Nature, 605, 2022
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7S5B
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7LCW
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6ADM
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6ADL
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6ADR
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6ADS
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6ADT
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7D4G
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7DX4
 | | The structure of FC08 Fab-hA.CE2-RBD complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Heavy chain of FC08 Fab, ... | | 著者 | Cao, L, Wang, X. | | 登録日 | 2021-01-18 | | 公開日 | 2021-04-21 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2.
Natl Sci Rev, 8, 2021
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7WPO
 | | Structure of NeoCOV RBD binding to Bat37 ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Cao, L, Wang, X, Tortorici, M.A, Veesler, D. | | 登録日 | 2022-01-24 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Close relatives of MERS-CoV in bats use ACE2 as their functional receptors.
Nature, 612, 2022
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7WPZ
 | | Structure of PDF-2180-COV RBD binding to Bat37 ACE2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | | 著者 | Cao, L, Wang, X, Tortorici, M.A, Veesler, D. | | 登録日 | 2022-01-24 | | 公開日 | 2022-11-30 | | 最終更新日 | 2023-03-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Close relatives of MERS-CoV in bats use ACE2 as their functional receptors.
Nature, 612, 2022
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7BTF
 | | SARS-CoV-2 RNA-dependent RNA polymerase in complex with cofactors in reduced condition | | 分子名称: | Non-structural protein 7, Non-structural protein 8, RNA-directed RNA polymerase, ... | | 著者 | Gao, Y, Yan, L, Huang, Y, Liu, F, Cao, L, Wang, T, Wang, Q, Lou, Z, Rao, Z. | | 登録日 | 2020-04-01 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
Science, 368, 2020
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